Characteristics and treatment outcomes of pan-urothelial cell carcinoma: a descriptive analysis of 45 patients

Abstract

The incidence of pan-urothelial cell carcinoma (panUCC), which refers to the presence of both bilateral (UTUC) and bladder tumor (BT), is relatively low. However, the profile of a panUCC cohort of patients remains to be elucidated. We reviewed the data of consecutive UTUC patients who received treatment at our center from 1999 to 2012. Overall, 45 patients were included in this study, with a median age of 64.5 years. Fourteen patients initially presented with unilateral UTUC, 11 initially with BT, and the remainder with multiple tumors. Patients with UTUC were more likely to manifest higher rates of muscle invasion and larger-sized tumors. Five patients were treated with complete urinary tract exenteration (CUTE), and most patients (73.3%) received combined management with conservative and radical surgery. After a median follow-up of 77 months, 18 patients (40%) died including 15 (33.3%) due to cancer. Higher tumor stage was the only risk factor predictive of worse survival. Nineteen patients experienced local recurrence after conservative surgery. This study indicated that PanUCC involves either synchronous or metachronous presentation of tumors with a high risk of tumor recurrence, progression, and dissemination after conservative surgery.

Rare tumours of the bladder: A Saudi registry based descriptive study

“…contradicts gender as a risk factor for rare bladder tumours, with the patient demographics in this study indicating a 3:1 female-to-male incidence of pan-urothelial cell carcinoma. 12 Despite this contradiction, their study supports our findings that the prevalence of rare tumours of the bladder is enhanced in those over 60 years of age, with Fang et al. reporting a mean age of 64.5 years in a cohort of 45 patients.…”

Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients

“…This pathology could account for the observed higher multifocal proportion and recurrence rate. The characteristics of AA-UTUC to “FAME-PIC” have been summarized in Figure 3 29,30…”

Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy

“…However, the higher rates of bladder and contralateral upper tract tumor recurrence may be explained by the field cancerization hypothesis, suggesting that the exposure to carcinogenic toxins in AA-containing herbs might induce neoplasms along the entire urothelial field. 21 , 22 …”