Characteristics associated with outcome in patients with first‐ever posterior fossa stroke

Villringer, Kersten; Florczak-Rzepka, M; Grittner, Ulrike; Brunecker, Peter; Tepe, H.; Nolte, Christian H.; Fiebach, Jochen B.

doi:10.1111/ene.13596

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…In the present study, the NIHSS score and leukocyte count on admission were identified as risk factors for stroke disability at 1 year after MIS, which was consistent with the findings of previous results [33][34][35][36]. A higher NIHSS score indicates severe neurological impairment.…”

Section: Discussionsupporting

confidence: 92%

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Liu

Lin

et al. 2020

BMC Neurol

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Background The prevalence of stroke recurrence, disability, and all-cause mortality of patients with minor ischemic stroke (MIS) remains problematic. The aim of the present study was to identify risk factors associated with adverse outcomes at 1 year after MIS in the Xi’an region of China. Methods This prospective cohort study included MIS patients above 18 years old with National Institutes of Health Stroke Scale (NIHSS) score ≤ 3 who were treated in any of four hospitals in Xi’an region of China between January and December 2015. The 1-year prevalence of stroke recurrence, disability, and all-cause mortality were evaluated, respectively. Multivariate logistic regression analysis was performed to assess the association between the identified risk factors and clinical outcomes. Results In this study, 131(10.5%, 131/1252) patients were lost to follow-up at 1 year. A total of 1121 patients were included for analysis, the prevalence of stroke recurrence, disability, and all-cause mortality at 1 year after MIS were 3.4% (38/1121), 9.3% (104/1121), and 3.3% (37/1121), respectively. Multivariate logistic regression analysis identified age, current smoking, and pneumonia as independent risk factors for stroke recurrence. Age, pneumonia, and alkaline phosphatase were independent risk factors for all-cause mortality. Independent risk factors for disability were age, pneumonia, NIHSS score on admission, and leukocyte count. Conclusions The 1-year outcomes of MIS in Xi’an region of China were not optimistic, especially with a high prevalence of disability. The present study indicated that age and pneumonia were the common independent risk factors affecting the 1-year outcomes of MIS in Xi’an region of China.

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Section: Discussionsupporting

confidence: 92%

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Liu

Lin

et al. 2020

BMC Neurol

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show abstract

“…In the present study, the NIHSS score and leukocyte count on admission were identi ed as risk factors for stroke disability at 1 year after MIS, which was consistent with the ndings of previous results [33][34][35][36]. A higher NIHSS score indicates severe neurological impairment.…”

Section: Discussionsupporting

confidence: 92%

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Liu

Lin

Lu³

et al. 2020

Preprint

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Background: The prevalence of stroke recurrence, disability, and all-cause mortality of patients with minor ischemic stroke (MIS) remains problematic. The aim of the present study was to identify risk factors associated with adverse outcomes at 1 year after MIS in the Xi’an region of China. Methods: This prospective cohort study included MIS patients above 18 years old with National Institutes of Health Stroke Scale (NIHSS) score ≤ 3 who were treated in any of four hospitals in Xi’an region of China between January and December 2015. The 1-year prevalence of stroke recurrence, disability, and all-cause mortality were evaluated, respectively. Multivariate logistic regression analysis was performed to assess the association between the identified risk factors and clinical outcomes. Results: In this study, 131(10.5%，131/1252) patients were lost to follow-up at 1 year. A total of 1,121 patients were included for analysis, the prevalence of stroke recurrence, disability, and all-cause mortality at 1 year after MIS were 3.4% (38/1121), 9.3% (104/1121), and 3.3% (37/1121), respectively. Multivariate logistic regression analysis identified age, current smoking, and pneumonia as independent risk factors for stroke recurrence. Age, pneumonia, and alkaline phosphatase were independent risk factors for all-cause mortality. Independent risk factors for disability were age, pneumonia, NIHSS score on admission, and leukocyte count. Conclusions: The 1-year outcomes of MIS in Xi’an region of China were not optimistic，especially with a high prevalence of disability. The present study indicated that age and pneumonia were the common independent risk factors affecting the 1-year outcomes of MIS in Xi’an region of China.

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“…Therefore, although NIHSS represents an easy-to-administer and widely validated scale, it seems more useful in patients with anterior circulation stroke than posterior circulation stroke [24]. The only exception was in case of pontine infarcts that tended to be associated with poorer long-term outcome compared with infarcts in other posterior fossa regions [25].…”

Section: Discussionmentioning

confidence: 99%

Infarction Patterns in Posterior Cerebral Circulation: Etiology and Prognosis

Alloush¹,

Moustafa²,

Fouad³

et al. 2019

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Study Objectives: About a quarter of strokes and transient ischemic attacks occur in the vertebrobasilar distribution. Vertebrobasilar stroke is particularly prone to devastating consequences especially brain stem infarctions due to damage of the regional brain tissues that contain vital centers, and is associated with high rates of death and disability. Study Design: This was across sectional observational prospective hospital-based study conducted on 60 patients with first-ever acute posterior circulation ischemic stroke. The aim of the current study was to determine the relationship between different risk factors and different infarction patterns in posterior circulation; single small lacunar lesion, single large lesion, or multiple scattered lesions. Diagnosis of ischemic stroke and stroke subtypes were defined using the Trial of ORG 10,172 in Acute Stroke Treatment (TOAST) criteria as well as clinical and brain imaging features. Stroke severity using National Institutes of Health Stroke Scale (NIHSS) score was done on admission, after 24 hours from admission, and at 7 days from onset of symptoms. The patients functional status was assessed by modified Rankin scale (mRS) done on admission and on discharge from hospital and at 7-day follow up from onset of symptoms. Patients were classified according to infarction patterns into a single small lacunar lesion (group I), a single large lesion (group II), and multiple scattered lesions (group III) 20 patients in each group. Results: There was no significant difference between the three groups as regard the presence of vascular risk factors and the only significant difference as regard vascular risk factors was atrial fibrillation (AF). There was significant difference between the three groups as regard the occurrence of previous transient ischemic attacks (TIA). There was significant difference between the three groups as regard NIHSS score on admission, after 24 hours, and at 7 days from admission. There were significant differences between the three groups as regard mRS score at discharge and at 7-day follow up from the onset of symptoms and the degree of

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Characteristics associated with outcome in patients with first‐ever posterior fossa stroke

Abstract: Infarct volume and clinical severity, but not infarct location, were the main contributors to poor long-term outcome in first-ever posterior fossa strokes.

Cited by 5 publications

References 26 publications

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Risk factors affecting the 1-year outcomes of minor ischemic stroke: results from Xi’an stroke registry study of China

Infarction Patterns in Posterior Cerebral Circulation: Etiology and Prognosis

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