Characteristics of 10-Year Survivors of Pancreatic Ductal Adenocarcinoma

Abstract

Although PADC remains a deadly disease, long-term survival is possible, even beyond the 10-year mark. Our adjusted analysis identified lymph node ratio, administration of adjuvant chemotherapy, and pathologic T stage as being the top 3 variables associated with LTS of PADC. In addition, our easy-to-use nomogram may be able to identify potential LTS among patients with resected PADC.

Does long-term survival exist in pancreatic adenocarcinoma?

“…The majority of these long-term survivors with a verified adenocarcinoma had undergone surgical resection (21 of 24 patients), comprising 10.1% of all surgically treated patients (N ¼ 207). The five-year survival rate of surgically treated patients in our study is comparable with the five-year survival rate of 12.2%, found in a recently published large cohort study, including 11 081 patients with surgically resected invasive pancreatic adenocarcinoma [13]. By contrast, our results seem inferior to the results found in the phase III CONKO-001 trial, in which patients who underwent surgical resection had a fiveyear survival of 15.0% [14].…”

Prognostic value of lymph node metastases detected during surgical exploration for pancreatic or periampullary cancer: A systematic review and meta-analysis

“…Furthermore, long-term survival following resection of pancreatic cancer is extremely rare, which restricts the skewness of survival data. 48 Attempts have been made to improve the estimations, but they remain to be validated. 49 Therefore the methods were used as described.…”

One Year Survival of Resectable Pancreatic Adenocarcinoma in Low Volume Centre Teaching Hospital

“…Pancreatic cancer remains a leading cause of death worldwide and is one of the few cancers associated with increased mortality (1). Resectability remains a matter of debate, particularly where a tumor involves vascular structure (1,2).…”

“…Resectability remains a matter of debate, particularly where a tumor involves vascular structure (1,2). Pancreatic adenocarcinoma has poor overall prognosis even after radical surgery, although a few patients may achieve 5 or 10-year survival following radical resection.…”

“…Two Pacreato-duodenectomy was the standard procedure for this case. High hospital mortality and morbidity rates associated with pancreatic surgery impose high demands on patient's selection and post-operative care (1,3). Centralization of surgical care has been shown to decrease post-operative mortality and morbidity, so the learning curve still must be achieved (3,4).…”