Characteristics of 12-Month Readmission for Hospitalized Patients with COPD: A Propensity Score Matched Analysis of Prospective Multicenter Study

Xu, Tingting; Sun, Wei; Zhao, Hongwei; Wang, Xinmin; Qi, Yuan; Zhang, Xijie; Shan, Mingguang; Zhang, Xiuwei; Zhao, Mingming; Sheng, Zebo; Zhang, Mingshun; Huang, Maosong; Ji, Ningfei

doi:10.2147/copd.s376909

Cited by 2 publications

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A systematic review and meta-analysis of chronic obstructive pulmonary disease in asia: risk factors for readmission and readmission rate

Lin,

Shen,

et al. 2024

BMC Pulm Med

View full text Add to dashboard Cite

Background Patients with chronic obstructive pulmonary disease (COPD) often require hospital readmission because of exacerbation of their condition. These frequent exacerbations reduce quality of life, work performance, and emotional health. However, few studies have investigated the risk factors for readmission and readmission rates in Asian patients with COPD. We conducted a systematic review to identify and understand the major risk factors for readmission in patients with COPD in Asia and the readmission rate. Method We searched PubMed, MEDLINE, Embase, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and China Biomedical Literature Database from database inception to September 2023 to identify studies on the readmission rate and risk factors for COPD in Asian patients. Chinese search terms included “COPD,” “chronic obstructive pulmonary disease,” “risk factors,” “recurrence,” “readmission,” and “acute exacerbation.” English search terms included “chronic obstructive pulmonary disease,” “COPD,” “lung emphysema,” “hospital admission,” “patient readmission,” and “readmission.” We extracted first author, publication year, research area, sample size, sex, risk factors, and readmission rates. The included studies’ quality was evaluated using the Agency of Healthcare Research and Quality. Meta-synthesis was conducted on readmission rates and risk factors for readmission. Subgroups were formed by age, research area, sample size, and research type, and meta-regression analysis was conducted on the 30-day, 90-day, and 365-day readmission rates of patients to determine the source of heterogeneity. Finally, the results’ robustness was evaluated using sensitivity analysis. Begg and Egger tests were used to evaluate publication bias. Results Meta-analysis of 44 studies, with 169,255 participants, indicated that risk factors for COPD readmission in Asia included: history of multiple hospital admissions, ≥ 3 comorbidities, male sex, ratio of eosinophils percentage ≥ 2%, body mass index < 18.5, smoking history, pulmonary heart disease comorbidity, COPD assessment test score > 20, nutritional disorder, Neutrophil-to-Lymphocyte ratio > 7, and FEV1 < 50. The 30-, 90-, and 365-day readmission rates of patients were 19%, 31%, and 42%, respectively. Conclusions Patients with COPD in Asia generally have high readmission rates and different risk factors. To reduce healthcare, economic, and social burdens, interventions should address major risk factors, early prevention, and screening. Supplementary Information The online version contains supplementary material available at 10.1186/s12890-024-03203-6.

show abstract

A systematic review and meta-analysis of chronic obstructive pulmonary disease in asia: risk factors for readmission and readmission rate

Lin,

Shen,

et al. 2024

BMC Pulm Med

View full text Add to dashboard Cite

show abstract

Development and Validation of a Nomogram model for Predicting One-Year Unplanned Readmission in Patients with Chronic Obstructive Pulmonary Disease

Zhu,

Lu,

Gao

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Unplanned readmission among patients with Chronic Obstructive Pulmonary Disease (COPD) is increasingly prevalent and imposes significant clinical and economic burdens. The aim of this study was to investigate the influencing factors of unplanned readmission in patients with COPD within 1 year after discharge, construct a risk prediction model and evaluate its effect. Methods We conducted a prospective observational study on 719 individuals diagnosed with COPD at HePu People's Hospital from January 2023 to May 2024. Participants were randomly divided into a model group (n = 427) and a validation group (n = 180), with a ratio of 7:3. We employed LASSO regression to identify optimal predictors and developed a nomogram prediction model using multivariable logistic regression. The model's performance was assessed through ROC curves, calibration plots, and decision curve analysis. Results Of 607 patients included in the final analysis, the incidence of readmission within one year was 40.0%. Multivariate logistic regression analysis identified several independent risk factors for readmission: white blood cell count (WBC; OR = 1.07, 95% CI = 1.03–1.12, P = 0.002), disease duration over ten years (OR = 1.36, 95% CI = 0.75–2.462, P = 0.043), more than one acute exacerbation in the past year (OR = 1.12, 95% CI = 1.05–1.20, P = 0.001), and concurrent respiratory failure (OR = 1.50, 95% CI = 0.97–2.33, P = 0.047). A predictive nomogram model was developed based on these factors. The nomogram exhibited an AUC of 0.719 in the model group and 0.676 in the validation group, demonstrating good predictive performance. The calibration curve showed a good degree of fit, and the Hosmer-Lemeshow test confirmed no significant deviations in model fit (P > 0.05).The clinical decision curve demonstrated that both the model and the validation groups provided better net benefits than the treat-all tactics or the treat-none tactics with threshold probability values of 0.25–0.95 and 0.25–0.85. Conclusion The developed nomogram model, integrating WBC count, disease duration, number of acute exacerbations within the past year and concurrent respiratory failure, effectively predicts the risk of one-year unplanned readmission in patients with COPD, offering a valuable tool for clinical decision-making.

show abstract

Characteristics of 12-Month Readmission for Hospitalized Patients with COPD: A Propensity Score Matched Analysis of Prospective Multicenter Study

Cited by 2 publications

References 50 publications

A systematic review and meta-analysis of chronic obstructive pulmonary disease in asia: risk factors for readmission and readmission rate

A systematic review and meta-analysis of chronic obstructive pulmonary disease in asia: risk factors for readmission and readmission rate

Development and Validation of a Nomogram model for Predicting One-Year Unplanned Readmission in Patients with Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About