Characteristics of achalasia subtypes in untreated <scp>C</scp>hinese patients: A high‐resolution manometry study

Min, Min; Li, Peng; Yang, Yun; Hou, Xiao Hua; Guo, Rong; Wang, Wei Feng; Wang, Xiao Xiao

doi:10.1111/j.1751-2980.2012.00622.x

Cited by 31 publications

(37 citation statements)

References 15 publications

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“…Long-term treatment response was evaluated in 13 (23.6%) patients more than 5 years after the treatment. A poor response was defined as an increased Eckardt symptom score of more than 3 after treatment13 or an aggravation of patient's subjective symptoms. A good response was defined when the Eckardt symptom scores were decreased to 3 or less after treatment15 or when the patient's subjective symptoms were improved.…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics and Treatment Outcomes of 3 Subtypes of Achalasia According to the Chicago Classification in a Tertiary Institute in Korea

Lee¹,

Kim²,

Kim³

et al. 2013

J Neurogastroenterol Motil

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Background/AimsAchalasia is classified into 3 types according to the Chicago classification. The aim of this study was to investigate characteristics and treatment outcomes of 3 achalasia subtypes in Korean patients.MethodsFifty-five patients diagnosed with achalasia based on conventional or high-resolution esophageal manometry were consecutively enrolled. Their clinical characteristics, manometric, endoscopic and esophagographic findings and treatment responses were analyzed among the 3 subtypes of achalasia.ResultsOf 55 patients, 21 (38.2%) patients had type I, 28 (50.9%) patients had type II and 6 (10.9%) patients had type III. The median follow-up period was 22.4 (interquartile range, 3.6-67.4) months. Type III patients were older than type I and II patients (70.0 vs. 46.2 and 47.6 years, P = 0.023). The width of the esophagus in type I patients was wider with more frequent bird's beak appearance on esophagogram than the other 2 types (P = 0.010 and 0.006, respectively). Of the 50 patients who received the evaluation for treatment response at 3 months, 7 patients (36.8% vs. 26.9%) were treated with pneumatic dilatation and 4 patients (21.1% vs. 15.4%) with laparoscopic Heller's myotomy in type I and II groups, respectively. The treatment responses of pneumatic dilatation and Heller's myotomy in type I group were 71.4 and 50.0% and in type II were 85.7 and 75.0%, respectively, and all 5 patients in type III group showed good response to medical therapy.ConclusionsClinical characteristics of 3 achalasia subtypes in Korean patients are consistent with other studies. Treatment outcomes are variable among 3 subtypes.

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Section: Methodsmentioning

confidence: 99%

Clinical Characteristics and Treatment Outcomes of 3 Subtypes of Achalasia According to the Chicago Classification in a Tertiary Institute in Korea

Lee¹,

Kim²,

Kim³

et al. 2013

J Neurogastroenterol Motil

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“…By comparing different surgical methods, to explore more effective and safer therapy, with an acceptable safety profile and excellent symptoms relief rate, POEM has been established as one of the best therapies for AC patients [4]. With the advantages of being less invasive, less costly, and shorter hospital stay, its preliminary efficacy such as short-term remission rate showed no difference with laparoscopic Heller myotomy (LHM) [5, 6]. However, there still exist some challenges which need further attention, such as the method of myotomy during the procedure.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients

Gong

Zhang

et al. 2017

Gastroenterology Research and Practice

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Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was collected (34 cases). 19 patients who received partial full-thickness myotomy were assigned to group A and 14 patients who received circular muscle myotomy were assigned to group B. The procedure-related parameters between the two groups were compared. Symptom relief rate and postprocedure manometry outcomes were compared to evaluate the efficacy. Procedure-related adverse events and complications were compared to evaluate the safety. Results. (1) Mean operation times were significantly shorter in group A than group B (62.42 ± 23.17 vs 87.86 ± 26.44 min, p < 0.01). (2) Symptom relief rate and postprocedure manometry outcomes had no statistical differences when compared between the two groups (all p > 0.05). (3) Comparison of procedure-related adverse events and complications had no statistical differences (all p > 0.05). Conclusion. Partial full-thickness myotomy had no significant differences in efficacy or safety with circular myotomy, but partial full-thickness myotomy significantly reduced the procedure time.

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“…Another 19 studies were further excluded due to insufficient data ( n = 13) or the unavailability of full‐text ( n = 6). Finally, nine eligible studies . including seven original articles and two conference abstracts were included in the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…All these articles were observational studies published between 2008 and 2015. Two of the nine studies evaluated both treatments, five only included PBD and the other two only examined LHM. Altogether 298 patients were included in the PBD group, with 180, 207 and 106 patients included in the 6‐, 12‐ and 24‐month follow‐up groups, respectively.…”

Section: Resultsmentioning

confidence: 99%

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High‐resolution manometric subtypes as a predictive factor for the treatment of achalasia: A meta‐analysis and systematic review

Nie

et al. 2016

J of Digest Diseases

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Characteristics of achalasia subtypes in untreated Chinese patients: A high‐resolution manometry study

Abstract: Type II is more common in untreated Chinese achalasia patients, and type II patients had better treatment outcomes than other types of patients. Large-sample multicenter trials are necessary in the future.

Cited by 31 publications

References 15 publications

Clinical Characteristics and Treatment Outcomes of 3 Subtypes of Achalasia According to the Chicago Classification in a Tertiary Institute in Korea

Clinical Characteristics and Treatment Outcomes of 3 Subtypes of Achalasia According to the Chicago Classification in a Tertiary Institute in Korea

Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients

High‐resolution manometric subtypes as a predictive factor for the treatment of achalasia: A meta‐analysis and systematic review

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