Characteristics of Acute Intestinal Infections in Children Hospitalized in the Clinic in Moscow

Ковалев, О. Б.; Новокшонов, А А; Россина, А. Л.; Чуелов, С. Б.; Молочкова, О. В.; Корсунский, А. А.; Кащенко, О. А.; Галеева, Е. В.; Крылатова, Н. И.; Пылаева, Е. Ю.; Караулова, В. Е.; Тесова, С. А.; Журавлев, Г. Ю.

doi:10.22627/2072-8107-2017-16-3-59-63

Cited by 6 publications

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“…Вирусные диареи сопровождаются развитием токсикоза с эксикозом [3][4][5], бактериальные -инфекционно-токсическим шоком, нейротоксикозом, гемолитико-уремическим синдромом [7]. При шигеллезе, сальмонеллезе, эшерихиозе, кампилобактериозе, клостридиозе нередко также развивается гемоколит [7][8][9][10][11]. Все эти случаи требуют проведения дифференциальной диагностики, госпитализации больного ребенка и оказания неотложной помощи [3][4][5][6][7][8][9][10][11][12].…”

Section: Clinico-etiological Characteristics Of Acute Intestinal Infeunclassified

“…В 2016 г. в два раза возросла доля норовирусной инфекции до 30,2% (в сравнении с 12% -в 2015 г. и 13,2% -в 2017 г.). Аналогичную ситуацию мы наблюдали в 2009 г., когда половину (52,1%) всех вирусных диарей составила норовирусная инфекция [11].…”

Section: о в молочкова и др клинико-этиологическая характеристикаunclassified

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Clinico-Etiological Characteristics of Acute Intestinal Infections in Hospitalized Children of Moscow in 2015—2017

Молочкова¹,

Ковалев²,

Россина³

et al. 2018

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A retrospective analysis of the etiological structure and clinical manifestations of acute intestinal infections was conducted in 8459 children hospitalized in a specialized infectious disease department at the Children's City Clinical Hospital No.9 in Moscow, in 2015—2017 based on the study of statistical reports of the Children's City Clinical Hospital No.9 for 2015—2017 and 2417 case histories of children aged 1 month to 18 years old.It was found that children with age 1—7 years of age (58.5%) are more likely to have acute intestinal infections and are hospitalized. The etiological interpretation of acute intestinal infections remains at a low level and is 28.6%. The leading causative agents of acute intestinal infections are viruses (83%), mainly rotaviruses (62%), less often noroviruses (18%). Topical diagnosis in the vast majority of patients with acute intestinal infections was gastroenteritis (74.7%), which leads to the development of toxicosis with exsiccosis, especially in young children, which is the reason for hospitalization in the hospital. The share of bacterial diarrhea is small (17%), among them salmonella is significant, and in young children — staphylococcal infection. In recent years, the relevance of identifying campylobacter and clostridium, these pathogens may be the cause of the development of diarrhea with hemoccolitis.

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Section: Clinico-etiological Characteristics Of Acute Intestinal Infeunclassified

Section: о в молочкова и др клинико-этиологическая характеристикаunclassified

Clinico-Etiological Characteristics of Acute Intestinal Infections in Hospitalized Children of Moscow in 2015—2017

Молочкова¹,

Ковалев²,

Россина³

et al. 2018

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“…Острые инфекционные диарейные заболевания (ОИДЗ) у детей остаются широко распространённой инфекцией, уступающей только острым респираторным заболеваниям. В структуре ОИДЗ преобладают инфекции, протекающие с синдромом водянистой диареи, гиперосмолярной и секреторной (вирусные диареи, холероподобные, вызванные УПФ, энтеротоксигенными эшерихиями) [1]. Значительно уменьшилась частота ОИДЗ инвазивного типа с экссудативной диареей [2][3][4].…”

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To the Question of Differential Diagnosis of Acute Infectious Invasive Diarrhea in Children

Гилёва¹,

Хохлова²,

Шатобалов³

et al. 2018

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Etiotropic Therapy of Infectious Diarrhea

Shakhmardanov

Nikiforov

2018

Epidemiology and Infectious Diseases

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The issues of etiotropic therapy of infectious diarrhea require a differentiated approach not only depending on the etiological factor, but also on the type of diarrhea caused by the location of the pathological process. Infectious diarrhea occur in the form of three main types: secretory, osmotic, inflammatory (invasive). Secretory and osmotic type of diarrhea are found in infectious gastroenteritis. In the mechanisms of elimination of infectious gastroenteritis pathogens, the following factors play a leading role: the destructive effect on pathogens in the lumen of the small intestine of trypsin, chemotrypsin and acid duodenal content entering the small intestine; the «killer» action of interepithelial large granular lymphocytes (M-cells) on pathogens; the increase in resistance of the small intestine epithelium under the influence of M-cell cytokines; the difficulty of intercellular distribution of pathogens due to faster than in the gut, small intestine epithelial cell renewal; microbial antagonism of representatives of normal intestinal microflora. The appointment of etiotropic agents in cases of infectious gastroenteritis, at least, suppresses the manifestations of microbial antagonism on the part of representatives of the normal intestinal microflora, creating prerequisites for the delay of the pathogen in the body. The inflammatory type of diarrhoea occurs when invasion of pathogens to the mucosal lining of the colon, with subsequent development of the destructive changes and the possibility of further translocation. Obstacles to adhesion, penetration and intercellular spread of invasive pathogens in the colon mucosa is much less than in the small intestine. Pathogens of the same genera, species and serological variants (e.g. Salmonella, Campylobacter) can cause both secretory and invasive types of diarrhea. However, the appointment of antibacterial therapy will depend on the location of the pathological process. When gastroenteritis etiotropic therapy in most cases is impractical. In the presence of clinical manifestations of colitis, involving the implementation of invasive properties of the causative agent, the appointment of etiotropic treatment is justified.

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Characteristics of Acute Intestinal Infections in Children Hospitalized in the Clinic in Moscow

Cited by 6 publications

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Clinico-Etiological Characteristics of Acute Intestinal Infections in Hospitalized Children of Moscow in 2015—2017

Clinico-Etiological Characteristics of Acute Intestinal Infections in Hospitalized Children of Moscow in 2015—2017

To the Question of Differential Diagnosis of Acute Infectious Invasive Diarrhea in Children

Etiotropic Therapy of Infectious Diarrhea

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