Characteristics of advanced gastric cancer with negative or only perigastric lymph node metastasis in elderly patients

Fujishima, Hajime; Ueda, Y.; Shiraishi, Norio; Hara, Takao; Ichimanda, M; Yuki, Satoshi; Shiroshita, Hidefumi; Etoh, Tsuyoshi; Ito, Masafumi

doi:10.1007/s40520-017-0767-y

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…45 LN s were metastatic and 37 LN s were pathologically inflammatory. The cases included gastrooesophageal junction carcinoma: Siewert II (8) and Siewert III (4), gastric body carcinoma (9), gastric antrum carcinoma (12) according to the location of gastric tumors; T1N0 (6), T1N1 (10), T1N2 (13) and T1N3 (4) according to post-operative T and N staging of gastric cancer; AS well, well-differentiated Perfusion CT parameters result Figure 3 demonstrated that metastatic LN and T1 gastric cancer had high blood perfusion and permeability; Figure 4 demonstrated that inflammatory LN s and T1 gastric cancer had moderate blood perfusion and permeability. The average BF and PS values, short axis diameters of metastatic and inflammatory LN s were detailed in Table 1.…”

Section: Clinicopathological Resultsmentioning

confidence: 99%

Retracted: An application study of CT perfusion imaging in assessing metastatic involvement of perigastric lymph nodes in patients with T1 gastric cancer

Sun

et al. 2019

The British Journal of Radiology

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Objective: To assess metastatic involvement of perigastric lymph nodes (PLNs) in patients with T1 gastric cancer by using CT perfusion imaging (CTPI). Methods: A total of 82 annotated PLNs of 33 patients with T1 gastric cancer confirmed by endoscopic ultrasonography underwent CTPI and portal phase CT scan before operation. The scan data were post-processed to acquire perfusion maps and calculate perfusion parameters including blood flow (BF) and permeability surface (PS). A radiologist measured the short axis diameters and perfusion parameters of PLNs. According to the post-operative pathology result, PLNs were divided into two groups: metastatic and inflammatory LNs. Perfusion parameters values and the size of PLNs between two groups were respectively compared statistically by t-test, and a receiver operating characteristic curve analysis was used to determine the optimal diagnostic cut-off value with sensitivity, specificity and area under the curve. Results: Examined 82 PLNs were metastatic in 45 (54.9%) and inflammatory in 37 (45.1%). The mean values of perfusion parameters and the short axis diameters in metastatic and inflammatory PLNs, respectively, were BF of 97.48 vs 81.21 ml/100 mg /min (p < 0.001), PS of 45.11 vs 36.80 ml/100 mg /min (p < 0.001), and the size of 1.51 cm vs 1.29 cm (p = 0.059). The sensitivity of 84.4%, specificity of 67.6% and area under the curve of 0.826 for BF with cut-off value of 88.89 ml/100 mg /min for differentiating metastatic from inflammatory nodes were higher than those of PS or the size of PLNs (p < 0.001). Conclusion: CT perfusion parameters values were different between metastatic and inflammatory PLNs in T1 gastric cancer. BF value may be the most reliable diagnostic marker of metastatic PLNs, and it is helpful for clinicians to choose treatment modality or management plan in T1 gastric cancer patients. Advances in knowledge: CTPI gives information on vascularization of LNs. BF value might be a more effective marker than PS or the size of LNs for differentiating metastatic from inflammatory LNs in patients with T1 gastric cancer.

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Section: Clinicopathological Resultsmentioning

confidence: 99%

Retracted: An application study of CT perfusion imaging in assessing metastatic involvement of perigastric lymph nodes in patients with T1 gastric cancer

Sun

et al. 2019

The British Journal of Radiology

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Predicting perigastric lymph node metastasis in gastric cancer with CT perfusion imaging: A prospective analysis

Sun

Wang

et al. 2020

European Journal of Radiology

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Characteristics of advanced gastric cancer with negative or only perigastric lymph node metastasis in elderly patients

Abstract: In the elderly patients, LN metastasis in advanced gastric cancer of ≤40 mm in diameter was limited to be within the perigastric area. Gastrectomy with only perigastric LN dissection may be adopted in these patients.

Cited by 2 publications

References 30 publications

Retracted: An application study of CT perfusion imaging in assessing metastatic involvement of perigastric lymph nodes in patients with T1 gastric cancer

Retracted: An application study of CT perfusion imaging in assessing metastatic involvement of perigastric lymph nodes in patients with T1 gastric cancer

Predicting perigastric lymph node metastasis in gastric cancer with CT perfusion imaging: A prospective analysis

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