Characteristics of amino acid metabolism in colorectal cancer

Abstract

In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.

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“…The prior CRC investigations failed to differentiate between individuals with CC and RC, perhaps resulting in inconsistent outcomes due to variations in the distribution of these two categories. Hence, it is essential to segregate the two categories of patients and conduct extensive sample validation in future research endeavors [36,37].…”

“…Elevated levels of the mitochondrial glycine metabolism enzymes in breast cancer are linked to increased mortality. The findings suggest that tumors' heightened need of glycine could serve as a metabolic weakness that can be specifically targeted to hinder the rapid growth of cancer cells [23,37,38]. Kathrine Roe Redalen conducted an analysis of metabolic profiles in tumor samples from patients with locally advanced rectal cancer.…”