Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study

Qi, Haotian; Jin, Guangming; Zou, Minjie; Young, Charlotte Aimee; Liu, Liyan; Lian, Zhangkai; Guo, Dongwei; Liu, Zhenzhen; Zheng, Danying

doi:10.1155/2022/6128832

Cited by 1 publication

(2 citation statements)

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“…The structure of the anterior chamber angle will be examined using a Tomey Casia 2 anterior segment optical coherence tomography (OCT) (Tomey, Tokyo, Japan). 16 …”

Section: Methods and Analysismentioning

confidence: 99%

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Visual prognosis and complications of congenital ectopia lentis: study protocol for a hospital-based cohort in Zhongshan Ophthalmic Center

Xu,

Ng,

Jin

et al. 2023

BMJ Open

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IntroductionCongenital ectopia lentis (CEL) is a rare ocular disease characterised by the dislocation or displacement of the lens. Patients with mild lens dislocations can be treated with conservative methods (eg, corrective eyeglasses or contact lenses). In contrast, patients with severe CEL usually require surgical management. However, few studies have focused on the visual prognosis and complications in conservative and surgical management of patients. This study aims to investigate the prognosis and complications in patients with CEL with conservative and surgical management, which is vital for CEL management, especially the choice of surgical timing and surgical method.Methods and analysisA cohort study will be conducted at Zhongshan Ophthalmic Center. We plan to recruit 604 participants diagnosed with CEL and aged ≥3 years old. Patients with mild lens subluxation and stable visual conditions will be included in the non-surgical group and follow-up at 1, 2 and 3 years after enrolment. Patients with severe lens subluxation who accept CEL surgery will be included in the surgical group. Different surgical techniques, including phacoemulsification, in-the-bag intraocular lens implantation (with or without capsular tension ring) and trans-scleral fixation, will be used depending on the severity of dislocation. Patients will be followed up at 3 months, and 1, 2 and 3 years postoperatively. Over a 5-year follow-up period, patients will receive a detailed ocular examination, including optometry, biological measurement, specular microscopy, ultrasound biomicroscopy, anterior segment and posterior segment optical coherence tomography (OCT), OCT angiography, echocardiography and questionnaires on vision-related quality of life. The primary outcome is the change of best-corrected visual acuity and the incidence of complications in both groups.Ethics and disseminationEthics approval was obtained from the ethics committee of the Zhongshan Ophthalmic Center (number: 2022KYPJ207). Study findings will be published in a peer-reviewed journal.Trial registration numberNCT05654025.

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“…The structure of the anterior chamber angle will be examined using a Tomey Casia 2 anterior segment optical coherence tomography (OCT) (Tomey, Tokyo, Japan). 16 …”

Section: Methods and Analysismentioning

confidence: 99%

“…The structure of the anterior chamber angle will be examined using a Tomey Casia 2 anterior segment optical coherence tomography (OCT) (Tomey, Tokyo, Japan). 16 9. The tilt and eccentricity of IOL will be evaluated using Pentacam AXL (Oculus, Germany).…”

Section: Examinationsmentioning

confidence: 99%