Characteristics of Asymptomatic Bacteriuria in Diabetes Mellitus Patients: A Retrospective Observational Study

Abstract

Background and objective The term asymptomatic bacteriuria (ASB) refers to the isolation of bacteria in a urine specimen of individuals without any symptoms of urinary tract infection (UTI). Diabetes mellitus (DM) is a disease involving multiple organ systems, characterized by its chronicity and hence endless complications including ASB. This study aimed to determine the characteristics of ASB and antibiotic susceptibility patterns among patients with diabetes. Materials and methods This was a retrospective observational study conducted in a tertiary care hospital. The study included patients with a diagnosis of diabetes with no signs and symptoms of UTI but who still showed the growth of an organism in urine culture. A total of 222 urine cultures were analyzed retrospectively, ensuring that they met the inclusion criteria through non-probability consecutive sampling. Results The mean age of the study participants was 62.89 ± 13.77 years; 76% of them were females, and 61% had a family history of diabetes. The most frequent organisms isolated were Escherichia coli (E. coli), Enterococcus, Klebsiella pneumonia, Pseudomonas aeruginosa, and Enterobacter species. A total of 20 subjects had dual bacterial growth in their cultures, with Enterococcus species (n=17) being the most common organism. Gender, family history of diabetes, levels of hemoglobin A1c (HbA1c), and advanced age were all found significantly associated with ASB. Conclusion Our study is the first of its kind to analyze and examine the risk factors associated with ASB in DM patients, and to identify the pathogens involved, along with assessing their antibiotic resistance profiles.

Investigation of Asymptomatic Bacteriuria in a Group of Iraqi Patients With Diabetes Mellitus Type 2 in Baghdad City, Iraq

“…2022 Staphylococcus aureus was the most frequently isolated bacteria (34%), followed by Enterobacter aerogenes (28%), and Klebsiella spp (10%). Compared with many previous studies, this is a different pattern of isolation because the results of those studies usually indicate a high prevalence of E. coli in diabetic patients, whether in cases of ASB or clinically apparent urinary tract infections [14]. It was observed through the current study that Escherichia coli is the fourth pathogen isolated in both diabetic and non-diabetic groups.…”

Asymptomatic bacteriuria in patients with type 2 diabetes mellitus in rural southwestern Nigeria: a cross-sectional study

“…The mean age (54.5 ± 11.4 years) of the participants was comparable to the mean age of the participants in the study by Banerjee et al ., probably because of similar sociodemographic factors and study design. 25 However, it was lower than that of the participants in the studies by Asghar et al ., 26 Odetoyin et al ., 10 and Matthiopoulou et al , 6 and higher than that of the participants in the studies by Venketesen et al . 7 and Bissong et al .…”

Prevalence and Associated Factors of Urinary Tract Infections among Diabetic Patients: A Study at Kiryandongo Hospital, Uganda

“…This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited results obtained showed that diabetes patients are 40% more prone to UTI due to metabolic disorders and lowered immunity than non-diabetic 5% in the same cohort study [15,16]. Considering the fact that UTI is the leading cause of morbidity among diabetics, a high prevalence of diabetes is likely to translate to a high prevalence of UTI [12].…”