Characteristics of autoantibodies associated with recurrent pregnancy loss

Chepanov, Sergey V.; Krivonos, Krivonos M.I.; Arzhanova, Arzhanova O.N.; T, Shlaсhtenko T.N. Shlaсhtenko; Saidov, Saidov N.Kh.; Kornyushina, Kornyushina E.A.; Chudotvorov, Chudotvorov K.N.; Sedihin, Sedihin V.Yu.; Selkov, S. A.; Reproductology, Saint Petersburg; Perinatology, Tajikistan

doi:10.18565/aig.2019.3.72-77

Cited by 3 publications

(2 citation statements)

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“…Важнейшей проблемой практического акушерства в настоящее время является самопроизвольный выкидыш, частота которого достигает 20 % от числа клинически диагностированных беременностей [1,2,3]. Значимым фактором репродуктивных потерь являются системные и локальные иммунные нарушения [4,5,6,7].…”

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“…Значимым фактором репродуктивных потерь являются системные и локальные иммунные нарушения [4,5,6,7]. Повышенная продукция цитокинов связывается исключительно с инфекционным фактором [1,8]. В настоящее время жировую ткань рассматривают как орган иммунной системы, а ожирение -как «воспаление» жировой ткани, которое протекает с повышенной секрецией провоспалительных цитокинов [5,9,10,11].…”

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The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders

Жуковец

Leshchenko

Andrievskaya

et al. 2020

Acta biomedica scientifica

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Background. Spontaneous miscarriage is the most common complication of pregnancy. Obesity increases the risk of adverse pregnancy outcomes. Aim of the study. To assess the cytokine profile as a marker of spontaneous miscarriage in women with metabolic disorders in the past medical history. Materials and methods. A prospective study of 170 adolescent girls with metabolic disorders was conducted between 2000 and 2013. Assessment of menstrual and reproductive function was carried out in 86, pregnancy outcomes – in 72 women. The average age of women in reproductive age was 21.95 ± 0.2 years, BMI – 24.7 ± 3.9 kg/m2. Results. In women with early pregnancy losses and metabolic disorders in past medical history, the predictor of an early pregnancy loss is an increase in the ratio of pro- and anti-inflammatory cytokines TNF-a/IL-10 in serum at 7–8 weeks of gestation (OR = 2.29). It was determined a significant correlation between the levels of pro- and anti-inflammatory cytokines of the same name in serum and chorion (IL-10 (p = 0.000) and TNF-α/IL-10 (p = 0.001), which indicates similar changes in chorion. The activity of NF-kB in chorion was 5.75 ± 0.51 pg/ml. Conclusions. The findings suggest that the cytokine balance of pro- and anti-inflammatory cytokines in women with metabolic disorders in past medical history is an important component in the development of early pregnancy losses.

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The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders

Жуковец

Leshchenko

Andrievskaya

et al. 2020

Acta biomedica scientifica

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Clinical significance of assessing autoantibody level in diagnostics of early and late fetal growth retardation

Ignatko

Yakubova

Megrabyan

et al. 2022

Akušerstvo, ginekologiâ i reprodukciâ

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Aim: analysis of diagnostic possibilities of early and late forms of fetal growth retardation (FGR) based on the study of autoimmune antibodies (АВ).Materials and Methods. A single center prospective cohort comparative study included 98 pregnant women: 79 with FGR (main group I) and 19 with physiological course of pregnancy (comparison group II). Pregnant women with FGR, depending on the time of manifestation, were divided into 2 subgroups: early form of FGR (group IA), late form of FGR (group IB). All patients underwent venous blood sampling to determine the serum content of autoimmune AB in 12 antigens using the Eli-P-test: for human chorionic gonadotropin antigen (hCG), for DNA, for β2-glycoprotein (β2-GP), for collagen, for fragment crystallizable of immunoglobulin G (Fc-IgG), for insulin, for thyroglobulin, for S100 protein, for surface antigen of germ cell and prostate (Spr), for thrombocyte membrane protein (TrM), for anti-neutrophil cytoplasmic antibodies (ANCA), for membrane antigen of glomerular cells (KiMS). Venous blood sampling was carried out in the main group at the time of diagnosis of FGR: with early manifestation of FGR – 29 [28; 31] weeks, with late manifestation of FGR – 5 [33; 36] weeks, in the comparison group II – 33 [32; 35] weeks.Results. For the diagnosis of an early form of FGR, statistical significance was shown by an increase in the level of the following autoimmune antibodies: АВ to hCG, to collagen, to S100 protein, to TrM, to ANCA, to KiMS (p = 0.037; р = 0.001; р = 0.013; р = 0.005; р = 0.003; p < 0.001, respectively), and for the diagnosis of late form of FGR – АВ to DNA, to collagen, to insulin, to S100 protein (p = 0.002; p = 0.003; p = 0.010; p < 0.001, respectively).Conclusion. АТ determination has shown its informative value in pregnant women with FGR, changes in the level of autoantibodies can act as a laboratory marker of early and late forms of FGR.

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Immune interface of patients with reproductive loss in the North-West region of the Russian Federation

Shengelia

Bespalova²,

Zhernakova³

et al. 2022

Journal of obstetrics and women's diseases

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BACKGROUND: Currently, more than a hundred immunological biomarkers are known that are important for fertilization, implantation and placentation. AIM: The aim of this study was to assess the immunological profile for the main allo- and autoantibodies in women with reproductive loss and infertility in the North-West region of the Russian Federation. MATERIALS AND METHODS: This prospective cohort study was conducted at the stage of pregnancy planning in 325 women with reproductive disorders (spontaneous miscarriages, missed abortions, infertility, IVF failures) on the premises of the D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine (St. Petersburg, Russia) from 2015 to 2022. The study assessed the immune interface of women with a history of reproductive disorders and matching loci of the HLA class II system (DQA1, DQB1, DRB1) among 100 married couples. RESULTS: In couples with reproductive disorders, coincidences of HLA class II allele (DQA1, DQB1, DRB1) loci were diagnosed in 14% (at 2 loci), 31% (at 3 loci), 14% (at 4 loci), 3% (at 5 loci) and 10% (at 6 loci) of couples. In 34.4% of women, we found an elevated number of spontaneously activated NK cells (CD107a). As many as 31.15% of women had a high level of antibodies to human chorionic gonadotropin. We found that 22.34% of women were carriers of at least one criteria antiphospholipid antibody, and 3.16% of women of two antiphospholipid antibodies. The diagnosis of antiphospholipid syndrome was not established in any patient. Non-criteria antiphospholipid antibodies were found in 6.15% of women. In 12.2% of women, we diagnosed a high level of antibodies to thyroperoxidase, while the average antibody value was 30.76 IU/ml. Only one patient had a high level of antisperm antibodies in the blood serum. CONCLUSIONS: In 59% of patients with a history of reproductive disorders, we identified some features of the immunological profile, which can lead to this pathology. Thus, 32% of women had a deviation in one immunological parameter, while 20% of patients had it in two parameters, and 7% in three or more parameters.

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Characteristics of autoantibodies associated with recurrent pregnancy loss

Cited by 3 publications

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The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders

The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders

Clinical significance of assessing autoantibody level in diagnostics of early and late fetal growth retardation

Immune interface of patients with reproductive loss in the North-West region of the Russian Federation

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