Characteristics of baseline PSA and PSA velocity in young men without prostate cancer: Racial differences

Tang, Peng; Du, Wei; Xie, Keqin; Fu, Jingao; Chen, Hui; Yang, Wenjun; Moul, Judd W.

doi:10.1002/pros.21418

Cited by 17 publications

(16 citation statements)

References 23 publications

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“…The median and mean PVs for our study cohort were 60 and 68 ml, respectively. The median and mean diagnostic PSA levels for our study cohort were 19.3 and 22.3 ng ml 21 , respectively. The median age, PSA and rate of positive DRE in men diagnosed with PCa were all statistically higher than those who did not have PCa (all P,0.05).…”

Section: Resultsmentioning

confidence: 82%

“…The rates of PCa in men with PVs of ,60 and o60 ml in the PSA of 10-19.9 ng ml 21 group were 40.6% and 15.1%, respectively, while the rates for those with PSAs of 20-50 ng ml 21 were 65.1% and 26.8%. The PCa rates for men with a PV of ,60 or o60 ml and with a positive DRE were 72.5% and 45.5%, respectively, while the rates for those with a negative DRE were 41.8% and 15.5%, respectively ( Table 3).…”

Section: Resultsmentioning

confidence: 85%

“…To our knowledge, this study was the first to examine the association between PV and PCa risk in Asian men with PSAs of 10-50 ng ml 21 . We found that decreased PV was associated with a higher risk of PCa detection using TRUS biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that Asian men have much lower incidences of PCa compared to other races. 13 A systematic review revealed that Asian men (primarily Japanese and Korean men) with PSAs of 2.0-10.0 ng ml 21 have lower rates of PCa than men with similar PSAs in Western countries. 14 Furthermore, we recently reported that the PCa rate in Chinese men with PSAs of 4.0-10.0 ng ml 21 was 20.2%, much lower than the rates reported for Western men in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…There are limited published data regarding the association of PV and PCa risk in Asian men with PSAs higher than the traditional Western PSA 'grey zone'. Given this lack of data, we evaluated the role of PV in diagnosing PCa in Asian men with PSAs of 10-50 ng ml 21 .…”

Section: Introductionmentioning

confidence: 99%

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Prostate volume as an independent predictor of prostate cancer in men with PSA of 10–50 ng ml−1

Tang¹,

Jin²,

Uhlman³

et al. 2013

Asian J Androl

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Prostate volume (PV) has been shown to be associated with prostate cancer (PCa) detection rates in men with a prostate-specific antigen (PSA) in the 'grey zone' (2.0-10.0 ng ml 21 ). However, the PSA 'grey zone' in Asian men should be higher because the incidence of PCa in Asian men is relatively low. Therefore, we evaluated the association between PV and PCa detection rates in men with PSAs measuring 10-50 ng ml 21 . Men who underwent a 13-core prostatic biopsy with PV documentation participated in the study. A multivariate stepwise regression was used to evaluate whether the PV at time of prostate biopsy could predict the risk of PCa. The rates of PCa among men in different PSA ranges, stratified by PV medians (,60 and o60 ml), were calculated. There were 261 men included in the final analysis. PV was the strongest predictor of PCa risk (odds ratio, 0.02; P,0.001) compared to other variables. The PCa rates in men with PVs measuring ,60 and o60 ml in the 10-19.9 ng ml 21 PSA group were 40.6% and 15.1%, respectively, while the rates for men with PSAs measuring 20-50 ng ml 21 were 65.1% and 26.8%. PV is an independent predictor of PCa in men with PSA measuring 10-50 ng ml 21 . In clinical practice, particularly for those countries with lower incidences of PCa, PV should be considered when counselling patients with PSAs measuring 10-50 ng ml 21 regarding their PCa risks.

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Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prostate volume as an independent predictor of prostate cancer in men with PSA of 10–50 ng ml−1

Tang¹,

Jin²,

Uhlman³

et al. 2013

Asian J Androl

Self Cite

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Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records

et al. 2022

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BackgroundProstate cancer (PCa) screening is not routinely conducted in men 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) and patient data applied towards early prediction of PCa may lead to earlier interventions and increased survival. We have developed machine learning models to predict PCa risk in men 55 and under using PRSs combined with patient data. MethodsWe conducted a retrospective study on 91,106 male patients aged 35 to 55 using the UK Biobank database. Five gradient boosting models were developed and validated utilizing routine screening data, PRSs, additional clinical data, or combinations of the three. ResultsCombinations of PRSs and patient data outperformed models that utilized PRS or patient data only, and the highest performing models achieved an area under the receiver operating characteristic curve of 0.788. Our models demonstrated a substantially lower false positive rate (35.4%) in comparison to standard screening using prostate speci c antigen (60-67%). ConclusionThis study provides the rst preliminary evidence for the use of PRSs with patient data in a machine learning algorithm for PCa risk prediction in men 55 and under for whom screening is not standard practice.

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Important Differences in Hematology Results and Hematological Diseases

Hall

2019

Patient-Centered Clinical Care for African Americans

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Characteristics of baseline PSA and PSA velocity in young men without prostate cancer: Racial differences

Abstract: The distributions of baseline PSA and PSA velocity in young men among Chinese, AA, and CA races are different. These characteristics shall be taken into account when using these variables to stratify risk of prostate cancer in young men.

Cited by 17 publications

References 23 publications

Prostate volume as an independent predictor of prostate cancer in men with PSA of 10–50 ng ml−1

Prostate volume as an independent predictor of prostate cancer in men with PSA of 10–50 ng ml−1

Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records

Important Differences in Hematology Results and Hematological Diseases

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