Characteristics of beef allergy in schoolchildren in Turkey

Topçu, Zekiye İlke Kılıç; Kaklıkkaya, Neşe; Baki, Ali; Orhan, Fazıl

doi:10.2500/aap.2018.39.4098

Cited by 9 publications

(22 citation statements)

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“…The OFC was prepared in line with current challenge protocols. 12,16 The titrated dose was given separately for beef and mutton as 1, 2, 7, 15, 25, 50 g with 20 min intervals. It was completed as not to exceed 100 g. The patients were monitored for at least 6 hours after the OFC.…”

Section: Oral Food Challengesmentioning

confidence: 99%

“…Red meat allergy is reported more frequently in the Black Sea region of Turkey. 12,[14][15][16] In a single-center study on the prevalence of red meat allergy in children in the black sea region, the primary beef allergy prevalence was reported to be 0.3%, based on the oral food challenge (OFC) test. 16 In a multicenter study in Turkey, it has been reported that beef is the second food responsible for anaphylaxis in children after milk.…”

mentioning

confidence: 99%

“…12,[14][15][16] In a single-center study on the prevalence of red meat allergy in children in the black sea region, the primary beef allergy prevalence was reported to be 0.3%, based on the oral food challenge (OFC) test. 16 In a multicenter study in Turkey, it has been reported that beef is the second food responsible for anaphylaxis in children after milk. 15 For this reason, it is critical to identify patients with red meat allergy to prevent potentially lifethreatening reactions at least in regions where red meat allergies are common.…”

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confidence: 99%

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Evaluation of red meat allergy patients and review of the literature

et al. 2021

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Background. It was reported that prevalence of red meat allergy in children was higher in our country than in western populations. However, the diagnosis of these patients is often delayed. The aim of the study was to present the clinical and laboratory characteristics of our red meat allergy patients. Methods. The data were collected retrospectively from the files of children with red meat allergy. Also, 6 adults with red meat allergies were recorded in the families of the children. Patients with symptoms associated with red meat allergy and sensitive to beef or mutton in prick-to-prick tests were recorded. Results. The median age of the 43 patients was 12 years (2-37), and 51% were male. Most of the patients were children (n=37, 86%). The median age was 10 years in children (2-17), and 54% were male. All of the children had dermatologic manifestations, 51% had respiratory symptoms, and 64% had anaphylaxis upon exposure to red meat. The anaphylaxis history was not associated with demographic, clinical and laboratory data. A total of 63% children had additional allergic diseases, and 75% of them were sensitive to both mutton and beef in prickto- prick tests. The median total IgE level of the children was 327 (20-3550) IU/mL, median eosinophil count was 210/mm < sup > 3 < /sup > (40-990) and mean vitamin D was 13.1 ± 1.2 mcg/L (n=27). Anaphylaxis occurred in 3 of 9 patients who received the open oral food challenge (OFC) test. After OFC, 3 patients continued to eat red meat without issues, and 1 patient was recommended to eat alternatives to red meat. Conclusions. Clinical and laboratory findings were heterogeneous in children with red meat allergy. Anaphylaxis risk seems to be higher than other food allergies. OFC test is more helpful in both diagnosis and alternative red meat selection compared to laboratory findings.

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Section: Oral Food Challengesmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Evaluation of red meat allergy patients and review of the literature

et al. 2021

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“…A similarly designed study of 689 adults in Pakistan demonstrated beef allergy in 0.9% of the subjects, a number that exceeded those with allergies to peanut, fish, soy and milk [9]. A recent report of 6000 schoolchildren in eastern Turkey found that 2.6% had symptoms consistent with IgE-mediated beef allergy based on parental report [10]. The number of subjects with confirmed beef allergy upon oral meat challenges was lower at 0.3%, but only a small fraction of those with suspected allergy, and none who reported delayed beef allergy symptoms, consented to the challenges.…”

Section: Introductionmentioning

confidence: 98%

Red meat allergy in children and adults

Wilson

Platts-Mills

2019

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of Review: To highlight recent advances in our understanding of the clinical features, prevalence and pathophysiology of red meat allergy.Recent findings: Allergic reactions to red (ie, mammalian) meat have historically been considered rare and described primarily in young atopic children. It is now clear that red meat allergy is not uncommon in some parts of the world in other age groups. Strikingly, the majority of these cases relate to specific IgE to galactose-α-1,3-galactose (α-Gal), an oligosaccharide of nonprimate mammals. The mechanism of sensitization in this syndrome relates to bites of certain hard ticks and the clinical reactions often have a delay of 3-6 hours. An additional form of red meat allergy relates to inhalant sensitization to mammalian proteins. The best characterized example involves cat-sensitized subjects with specific IgE to cat serum albumin who can react to ingested pork because of cross-sensitization to pork serum albumin.Summary: Red meat allergy is more common than previously appreciated and relates to at least three different forms that are distinguished by mechanisms of sensitization and have characteristic clinical and immunologic features.

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“…In the first report, Kılıç Topçu et al 9 presented their evaluation of the prevalence and characteristics of IgE-mediated beef allergy in urban schoolchildren. They reported that the presence of family history, serum IgE levels to beef, and skin test positivity were independently associated with positive, double-blind, placebo controlled challenge results.…”

mentioning

confidence: 99%