Technology is the main cause of emerging careers in life science. As technological change occurs at unprecedented speeds, it becomes increasingly important to develop mechanisms that can foster skills highly demanded in emerging careers. Technical and Vocational Education and Training (TVET) is an integral part of the education system with mechanisms that can prepare such skills. Some of emerging careers in life science includes Biotechnology and Bioinformatics. This paper examines some of compelling issues and challenges for consideration in TVET training when aligning skills for emerging careers in life science. The paper also identifies priorities of improvement in science education and strategies for interventions that will link life science to job creation and career skills. The compelling issues and strategies includes; making quality education in science a priority in secondary schools and to recognize its impact far into the future for emerging careers in life science, training with strong link with the industries and innovative delivery of instruction which can actively engage students in learning and developing skills. Other considerations include a carefully sequenced and flexible curriculum which must meet increasing and ever-changing knowledge and skills demands. Also hands-on activities in laboratories should remain an indispensable constituent of effective learning and acquiring skills. Awareness rising for aspirants in emerging careers is also very important which includes encouraging more women in those emerging careers in life science. Emerging careers in life science are expected to substantially create an impact on scientific, social welfare and economic development of