Characteristics of bone metabolism markers during the healing of osteoporotic versus nonosteoporotic metaphyseal long bone fractures: a matched pair analysis

Abstract

In this work, the first molecular biological aspects of osteoporotic fracture healing have been uncovered, helping to explain the mechanisms of delayed fracture healing in osteoporotic bone. The early decrease of reduced β-CTX as well as elevated BAP during the healing process may be the first aspects within the delayed healing of osteoporotic bone. Further studies are necessary in order to achieve more detailed insight to fracture healing and to ascertain the progression of fracture healing as being essential (criteria) for therapeutic decision making.

Correction: Characteristics of bone turnover in the long bone metaphysis fractured patients with normal or low Bone Mineral Density (BMD)

“…After this article [ 1 ] was published, concerns were raised about similarities between this work and a study published previously in [ 2 ]. The two articles address related research questions and present similar questions, and the Methods sections and Table 1 of each article indicate that the studies used overlapping populations.…”

“…[ 2 ] reportedly compares osteoporotic versus nonosteoporotic patients where [ 1 ] compares low versus normal bone mineral density patients,…”

“…[ 1 ] examines outcomes not reported in [ 2 ] including TRAP5b, TGFβ1, and fracture consolidation data.…”

Clinical Utility of Biochemical Marker of Bone Turnover: Fracture Risk Prediction and Bone Healing

“…[ 34 35 36 ] The levels of NTX, CTX and DPD during fracture healing in osteoporotic patients showed significantly higher during fracture healing despite low BMD compared to non-osteoporotic patients. [ 34 36 ] This is different from our general thinking that low BMD results in decreased levels of bone markers during fracture healing and might suggest that preexistent elevated bone turnover in patients with osteoporosis. In addition, the concentration of BRM is higher in females than males/in hip fractures than in other fractures.…”

“…In addition, the concentration of BRM is higher in females than males/in hip fractures than in other fractures. [ 34 36 37 ] Therefore, the relationship between patient's various factors and the level of BRM remains unclear.…”