Characteristics of bronchiectasis in Korea: First data from the Korean Multicentre Bronchiectasis Audit and Research Collaboration registry and comparison with other international registries

Lee, Sang‐Do; Choi, Hayoung; Chalmers, James D.; Dhar, Raja; Nguyen, Tu Q.; Visser, S.; Morgan, Lucy; Oh, Yeon Mok

doi:10.1111/resp.14059

Cited by 52 publications

(42 citation statements)

References 4 publications

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“…Exclusion criteria were as follows: (1) bronchiectasis due to cystic fibrosis; (2) traction bronchiectasis associated with interstitial lung disease; (3) patients being actively treated for pneumonia, pulmonary TB, or non-tuberculous mycobacteria (NTM) infection; (4) patients who were unable or unwilling to provide informed consent; and (5) pregnant patients. The detailed registry protocol and baseline characteristics of the patients were described previously [3,6].…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…The increased prevalence of bronchiectasis has led to the establishment of several prospective multicentre bronchiectasis registries [3][4][5]. Research from the international registries revealed that the aetiologies of bronchiectasis varied according to region, and tuberculosis (TB) was most common in Asian countries, including India and South Korea [6,7]. Therefore, elucidating specific clinical characteristics of patients with post-TB bronchiectasis is essential to successfully manage Asian patients with bronchiectasis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics of Patients with Post-Tuberculosis Bronchiectasis: Findings from the KMBARC Registry

Choi

Lee

Won

et al. 2021

JCM

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The clinical characteristics of patients with post-tuberculosis (TB) bronchiectasis have not been well evaluated. We enrolled 598 patients with bronchiectasis who participated in the Korean prospective bronchiectasis registry and compared the characteristics of post-TB bronchiectasis (19.7%) with post-infectious (19.6%), idiopathic (40.8%), and other (19.9%) bronchiectasis. The patients with post-TB bronchiectasis had a lower body mass index, higher rate of chronic obstructive pulmonary disease, and lower rate of asthma than those in the other groups. The patients with post-TB bronchiectasis had more upper lobe involvement, more severe radiological extent, and worse lung function than those in the other groups. Long-acting muscarinic antagonist/long-acting ß agonist use and mucolytics were more commonly used in the patients with post-TB bronchiectasis than those in the other groups, while inhaled corticosteroid/long-acting ß agonist was less commonly used. There were no significant intergroup differences in bronchiectasis severity scores except for FACED, the number of exacerbations, and quality of life. Post-TB bronchiectasis is characterised by reduced lung function and higher rates of mucolytic use when compared with other bronchiectasis; thus, adequate bronchodilator use and airway clearance techniques may alleviate symptom burden in this population.

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Section: Study Design and Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Patients with Post-Tuberculosis Bronchiectasis: Findings from the KMBARC Registry

Choi

Lee

Won

et al. 2021

JCM

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“…Bronchiectasis itself can cause obstructive ventilatory impairment (31). The high rate of COPD can be also attributable to the relatively high prevalence of asthma and TB in this cohort (14). The current Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations indicate asthma or TB as a risk factor of COPD (32).…”

Section: Discussionmentioning

confidence: 97%

“…The Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC) is a prospective, observational study of bronchiectasis in Korea (13,14). The KMBARC uses the Korean version of the Bronchiectasis Health Questionnaire (BHQ) for QoL measurement (15), which has the advantage of simplicity over other QoL measurements for bronchiectasis.…”

Section: Introductionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease Is Associated With Decreased Quality of Life in Bronchiectasis Patients: Findings From the KMBARC Registry

Kim

Jeong

et al. 2021

Front. Med.

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Most studies have evaluated the impact of non-cystic fibrosis bronchiectasis (hereafter referred to as bronchiectasis) on quality of life (QoL) in patients with chronic obstructive pulmonary disease (COPD) using COPD cohorts. Accordingly, the impact of COPD on QoL in patients with bronchiectasis is not well-elucidated. We used the Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC) registry between August 2018 and December 2019, a prospective observational cohort that enrolled patients with bronchiectasis in Korea. We evaluated co-occurrence exposure to COPD in bronchiectasis patients, and the primary outcome was QoL according to the Bronchiectasis Health Questionnaire (BHQ). We also investigated factors associated with decreased QoL, defined as the lowest quartile of the total BHQ score. Of 598 patients with bronchiectasis, 372 (62.2%) had COPD. Bronchiectasis patients with COPD had a significantly lower total BHQ score compared with those without COPD [median = 63.1 (interquartile range: 54.8–68.6) vs. 64.8 (57.4–70.8), p = 0.020]. Multivariable analysis revealed that dyspnea [adjusted odds ratio (aOR) = 3.21, 95% confidence interval (CI) = 1.21–8.60], depression (aOR = 1.28, 95% CI = 1.16–1.44), and fatigue (aOR = 1.05, 95% CI = 1.01–1.09) were significantly associated with decreased QoL in bronchiectasis patients with COPD. In conclusion, bronchiectasis patients with COPD had significantly decreased QoL than patients without COPD. In bronchiectasis patients with COPD, dyspnea, depression, and fatigue were associated with decreased QoL.

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“…The prevalence and disease burden of bronchiectasis has increased worldwide [ 3 - 6 ], including South Korea [ 1 , 7 - 9 ]. One of the obstacles to adequately addressing the disease burden of bronchiectasis is its heterogeneity [ 10 , 11 ], as it may be caused by or related to various respiratory or systemic diseases [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Developing a Diagnostic Bundle for Bronchiectasis in South Korea: A Modified Delphi Consensus Study

et al. 2022

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Background: Because the etiologies of bronchiectasis and related diseases vary significantly among different regions and ethnicities, this study aimed to develop a diagnostic bundle for bronchiectasis in South Korea.Methods: A modified Delphi method was used to develop expert consensus statements on a diagnostic bundle for bronchiectasis in South Korea. Initial statements proposed by a core panel, based on international bronchiectasis guidelines, were discussed in an online meeting and two email surveys by a panel of experts (≥70% agreement).Results: The study involved 21 expert participants, and 30 statements regarding a diagnostic bundle for bronchiectasis were classified as recommended, conditional, or not recommended. The consensus statements of the expert panel were as follows: A standardized diagnostic bundle is useful in clinical practice; diagnostic tests for specific diseases, including immunodeficiency and allergic bronchopulmonary aspergillosis, are necessary when clinically suspected; initial diagnostic tests, including sputum microbiology and spirometry, are essential in all patients with bronchiectasis, and patients suspected with rare causes such as primary ciliary dyskinesia should be referred to specialized centers.Conclusion: Based on this Delphi survey, expert consensus statements were generated including specific diagnostic, laboratory, microbiological, and pulmonary function tests required to manage patients with bronchiectasis in South Korea.

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Characteristics of bronchiectasis in Korea: First data from the Korean Multicentre Bronchiectasis Audit and Research Collaboration registry and comparison with other international registries

Cited by 52 publications

References 4 publications

Clinical Characteristics of Patients with Post-Tuberculosis Bronchiectasis: Findings from the KMBARC Registry

Clinical Characteristics of Patients with Post-Tuberculosis Bronchiectasis: Findings from the KMBARC Registry

Chronic Obstructive Pulmonary Disease Is Associated With Decreased Quality of Life in Bronchiectasis Patients: Findings From the KMBARC Registry

Developing a Diagnostic Bundle for Bronchiectasis in South Korea: A Modified Delphi Consensus Study

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