2021
DOI: 10.1136/lupus-2021-000507
|View full text |Cite
|
Sign up to set email alerts
|

Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus

Abstract: ObjectivesCardiovascular autonomic neuropathy (CAN) may affect the clinical course of SLE leading to reduced quality of life. CAN is assessed by heart rate variability (HRV) measures and cardiovascular autonomic reflex tests (CARTs). In patients with SLE, we aimed to determine the characteristics of CAN and if CAN associates with health-related quality of life (HRQoL).MethodsPatients with SLE and healthy controls (HCs) were CAN tested with 5 min HRV and three CARTs to determine parameters reflecting parasympat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
7
0

Year Published

2022
2022
2025
2025

Publication Types

Select...
6
2

Relationship

2
6

Authors

Journals

citations
Cited by 13 publications
(7 citation statements)
references
References 42 publications
0
7
0
Order By: Relevance
“…A total of 79 patients with an established diagnosis of SLE according to the 1997 American College of Rheumatology Revised criteria were included from October 2018 through March 2019 from our tertiary referral center for systemic autoimmune diseases at Copenhagen University Hospital, Rigshospitalet, Denmark. Patients were recruited as previously described [ 33 ]. Patients were 18 years of age or older.…”
Section: Methodsmentioning
confidence: 99%
“…A total of 79 patients with an established diagnosis of SLE according to the 1997 American College of Rheumatology Revised criteria were included from October 2018 through March 2019 from our tertiary referral center for systemic autoimmune diseases at Copenhagen University Hospital, Rigshospitalet, Denmark. Patients were recruited as previously described [ 33 ]. Patients were 18 years of age or older.…”
Section: Methodsmentioning
confidence: 99%
“…Basal activity of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the suppression of peripheral inflammation by the release of corticosterone. Additionally, decreased parasympathetic (vagal) tone, as indicated by decreased heart rate variability, has been consistently identified in clinical studies involving SLE patients since 1997 ( Laversuch et al, 1997 ; Maule et al, 1997 ; Thanou et al, 2016 ; Matusik et al, 2018 ; Zinglersen et al, 2021 ). An impaired HPA axis is present in SLE and may explain why renal inflammation is not resolved in SLE ( Rovenský et al, 1998 ; Pham and Mathis, 2018 ).…”
Section: Introductionmentioning
confidence: 97%
“…SLE may be also associated with Sjögren syndrome or antiphospholipid syndrome, among others. Consequently, patients with SLE may refer to a reduced health-related quality of life (HRQoL) [ 2 ]. Treatment with hydroxychloroquine (HCQ) increases life expectancy in these patients [ 3 , 4 ], as well as increasing their HRQoL [ 5 ].…”
Section: Introductionmentioning
confidence: 99%