Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan

Li, Te Mao; Yu, Yang; Tsai, Fuu Jen; Cheng, Chi Fung; Wu, Yang Chang; Ho, Tsung Jung; Liu, Xiang; Tsang, Hsinyi; Lin, Ting Hsu; Liao, Chien-Chang; Huang, Shao Mei; Li, Ju Pi; Lin, Ji-Ping; Lin, Chih-Chien; Liang, Wen Miin; Lin, Ying

doi:10.1016/j.jep.2017.10.031

Cited by 50 publications

(40 citation statements)

References 53 publications

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“…The effect of TCM treatment on patient survival of various cancer types has been reported for gastric cancer, 10 liver cancer, 22 head and neck cancer, 23 breast cancer, 24 lung cancer, 12,25,26 prostate cancer, 11 myeloid leukemia, 21 and pancreatic cancer. 27 The literature to date supports the effectiveness of TCM for alleviating chemotherapy, radiotherapy, and surgery-induced side effects.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Different Patterns of Traditional Chinese Medicine Treatment and All-Cause Mortality Among Cancer Patients

Chen

Pan

et al. 2019

Integr Cancer Ther

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Background: Cancer patients receiving Western medical treatment, frequently seek Traditional Chinese Medicine (TCM) to alleviate adverse effects and prolong survival. Objective: This study evaluated the association between the use of TCM and cancer survival rate. Research into the effect of TCM on patient survival is limited, this analysis focused on 3 patterns of TCM use. Methods: Three retrospective cohorts with different patterns of TCM use were selected from the National Health Insurance Research Database of Taiwan and analyzed. Patients with newly diagnosed cancer between 1997 and 2012 were classified into groups of prediagnosis, postdiagnosis, and continuous TCM use associated with awareness of cancer diagnosis. All demographic and clinical data were analyzed. Results: After propensity score matching, longevity of the postdiagnosis and continuous TCM user was significantly longer than the non-TCM user. The adjusted hazard ratios of death in postdiagnosis and continuous TCM use groups (0.59 and 0.61, respectively) were lower than the non-TCM use group. Conclusion: The analysis suggests that cancer patients using TCM in conjunction with Western medical treatment exhibited a higher survival rate than patients not using TCM treatment.

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Section: Discussionmentioning

confidence: 99%

The Association Between Different Patterns of Traditional Chinese Medicine Treatment and All-Cause Mortality Among Cancer Patients

Chen

Pan

et al. 2019

Integr Cancer Ther

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“…Therefore, compounds that can sensitize patients to chemotherapy or reverse drug resistance may improve patient outcomes. chinese herbs and their natural extracts have exhibited beneficial anticancer properties by mediating the expression of epithelial-to-mesenchymal transition-associated markers and the expression of genes associated with drug resistance, apoptosis and cell cycle progression (30,31). Tangerine peel is a common chinese herbal medicine containing a variety of natural compounds, of which hesperidin and its derivative, hesperetin, have exhibited antitumor properties in vitro and in vivo (19,24,32,33).…”

Section: Discussionmentioning

confidence: 99%

Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway

Kong¹,

Ling

Chen³

et al. 2020

Int J Mol Med

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Lung cancer is the leading cause of cancer-associated mortality worldwide. cisplatin (ddP) is a first-line chemotherapeutic drug for the treatment of lung cancer; however, the majority of patients develop resistance to ddP. P-glycoprotein (P-gp), also referred to as multidrug resistance (MdR) protein 1, is associated with an MdR phenotype, which results in failure of cancer chemotherapy; thus, identifying effective MdR pump inhibitors may improve the outcomes of patients who develop resistance to treatment. Hesperetin is a derivative of hesperidin, which is extracted from tangerine peel and exhibits multiple antitumor properties. In the present study, human lung adenocarcinoma A549 and A549/ddP cells were treated with different concentrations of hesperetin and DDP, respectively. Furthermore, rhodamine 123 efflux assays, cell counting Kit-8 assays, immunofluorescence, reverse transcription-quantitative PcR and western blot analysis were used to elucidate the mechanisms underlying the effects of hesperetin On A549/ddP cells. Additionally, a xenograft model of lung cancer in nude mice was established to explore the effects of hesperetin on A549/ddP cell growth in vivo. The results demonstrated that hesperetin sensitized A549/ddP cells to ddP. In vivo, hesperetin pretreatment significantly inhibited tumor growth. Mechanistically, hesperetin markedly decreased the expression of P-gp and increased the intracellular accumulation of the P-gp substrate, rhodamine 123, in A549/ddP cells. In addition, pretreatment of A549/ddP cells with hesperetin significantly inhibited nuclear factor (NF)-κB (p65) activity and its nuclear translocation. Taken together, the results of the present study suggest that hesperetin reversed P-gp-mediated MdR by decreasing P-gp expression in A549/ddP cells, which was associated with inhibition of the NF-κB signaling pathway. These findings may provide the basis for the use of hesperetin clinically to reverse MdR.

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“…It was recorded as a tonic for the treatment of weakness including fatigue, visceroptosis, gastrointestinal motility disorder, and rectal prolapse due (71). They indicated that the use of Chinese herbal medicine as an adjunctive therapy might reduce the mortality hazard ratio of lung cancer patients and Bu-zhong-yi-qi-tang was found to be the top formula prescribed by traditional Chinese physicians for lung cancer patients.…”

Section: Bu-zhong-yi-qi-tangmentioning

confidence: 99%

An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics

Wang

Cui

et al. 2018

BST

192

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Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan

Cited by 50 publications

References 53 publications

The Association Between Different Patterns of Traditional Chinese Medicine Treatment and All-Cause Mortality Among Cancer Patients

The Association Between Different Patterns of Traditional Chinese Medicine Treatment and All-Cause Mortality Among Cancer Patients

Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway

An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics

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