Characteristics of Choledochal Cysts in Neonates and Early Infants

Todani, Takuji; Urushihara, Naoto; Morotomi, Yoshiki; Watanabe, Yotaro; Uemura, Sadashige; Noda, Takuo; Sasaki, K.; Yoshikawa, Mikiko

doi:10.1055/s-2008-1066189

Cited by 68 publications

(35 citation statements)

References 2 publications

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“…Mean age of presentation in CDC patients was 4.42 ± 2.43 range 6 months -12 years, WHICH WAS similar to reported by authors like Todani et al and de Vries et al [5,6]. Most common presentation of CDC in our series was pain abdomen in 16 (53.33%) cases followed by pain abdomen with jaundice in 7 (23.33%) and incidental finding in 7 (23.33%) cases , similar presentation was reported by.…”

Section: Discussionsupporting

confidence: 76%

Comparison of MRCP with Intraoperative Cholangiography in Paediatric Choledochal Cyst and Biliary Atresia

Hamid¹,

Bhat²,

Baba³

et al. 2017

JGPLD

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Background: Hepatobiliary and pancreatic disorders in children are infrequent and include Duct union (APBD -union), Extra hepatic biliary atresia (EHBA), Caroli's disease, primary sclerosing cholangitis, pancreas divisum and pancreatic duct abnormalities. A range of investigations have been used for evaluation of these disorders in children ranging from sonography, HIDA Scan computed tomography, ERCP, Cholangiography and MRCP. Among these MRCP is a non-invasive investigation which has the potential to delineate the hepatobiliary pancreatic ductal system preoperatively to help surgeon in diagnosis and operative planning

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Section: Discussionsupporting

confidence: 76%

Comparison of MRCP with Intraoperative Cholangiography in Paediatric Choledochal Cyst and Biliary Atresia

Hamid¹,

Bhat²,

Baba³

et al. 2017

JGPLD

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“…10,11 Based on these characteristics, a distinct category of "neonatal group of CDBD" was proposed. 12 Lugo-Vicente 13 reported that 60% of neonates with a prenatal diagnosis of CDBD have liver fibrosis by the age of 9 h to 6 months old. Suita et al 14 reported that all of their neonatal group had some degree of liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Histological Classification of Liver Fibrosis and its Impact on the Postoperative Clinical Course of Patients with Congenital Dilatation of the Bile Duct

et al. 2006

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“…Amylase levels in bile are markedly elevated ([10,000 IU/l) in most cases of PBM, but are not elevated at all in some cases [15,16]. Furthermore, elevation of pancreatic enzyme levels in bile and hyperplastic changes to the gallbladder mucosa are sometimes observed in some cases with a relatively long common channel in which the effect of the sphincter reaches the pancreaticobiliary junction (high confluence of pancreaticobiliary ducts) [17][18][19].…”

Section: Diagnostic Criteria For Pbm 2013mentioning

confidence: 99%

Pancreaticobiliary maljunction and biliary cancer

et al. 2014

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Pancreaticobiliary maljunction (PBM) is a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. Japanese clinical practice guidelines on how to deal with PBM were made in 2012, representing a world first. According to the 2013 revision to the diagnostic criteria for PBM, in addition to direct cholangiography, diagnosis can be made by magnetic resonance cholangiopancreatography (MRCP), 3-dimensional drip infusion cholangiography computed tomography, endoscopic ultrasonography (US), or multiplanar reconstruction images by multidetector row computed tomography. In PBM, the common channel is so long that sphincter action does not affect the pancreaticobiliary junction, and pancreatic juice frequently refluxes into the biliary tract. Persistence of refluxed pancreatic juice injures epithelium of the biliary tract and promotes cancer development, resulting in higher rates of carcinogenesis in the biliary tract. In a nationwide survey, biliary cancer was detected in 21.6 % of adult patients with congenital biliary dilatation (bile duct cancer, 32.1 % vs. gallbladder cancer, 62.3 %) and in 42.4 % of PBM patients without biliary dilatation (bile duct cancer, 7.3 % vs. gallbladder cancer, 88.1 %). Pathophysiological conditions due to pancreatobiliary reflux occur in patients with high confluence of pancreaticobiliary ducts, a common channel C6 mm long, and occlusion of communication during contraction of the sphincter. Once the diagnosis of PBM is established, immediate prophylactic surgery is recommended. However, the surgical strategy for PBM without biliary dilatation remains controversial. To detect PBM without biliary dilatation early, MRCP is recommended for patients showing gallbladder wall thickening on screening US under suspicion of PBM.

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Characteristics of Choledochal Cysts in Neonates and Early Infants

Cited by 68 publications

References 2 publications

Comparison of MRCP with Intraoperative Cholangiography in Paediatric Choledochal Cyst and Biliary Atresia

Comparison of MRCP with Intraoperative Cholangiography in Paediatric Choledochal Cyst and Biliary Atresia

Histological Classification of Liver Fibrosis and its Impact on the Postoperative Clinical Course of Patients with Congenital Dilatation of the Bile Duct

Pancreaticobiliary maljunction and biliary cancer

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