Background:
Clear cell renal cell carcinoma (ccRCC) incidence and death have changed considerably in recent years. The purpose of our study was to investigate the incidence, survival, and tumor characteristics of ccRCC in the year of diagnosis and to compare their changes over time by using the Surveillance, Epidemiology, and End Results (SEER) database.
Materials and Methods:
Our study participants were drawn from the SEER database (2000-2017) and analyzed using SEER*Stat 8.4.1. Age-standardized incidence rates were calculated to compare incidence rates across time. In addition, we used Kaplan-Meier curves to calculate overall survival (OS) and Cox proportional hazards models to explore risk factors associated with mortality outcomes in patients with ccRCC.
Results:
In the SEER analysis from 2000 to 2017, we included a total of 101,892 patients with ccRCC. The increasing trend in age-adjusted incidence of ccRCC has remained relatively stable over the years, increasing from 2.63 per 100,000 in 2000 to 8.79 per 100,000 in 2017. The increase in the incidence of patients at a localized stage plays a decisive role in the overall increase in the incidence of ccRCC. In the general population, patients diagnosed in 2009-2017 had a higher survival rate (5-year OS rate = 73.45%) than those diagnosed in 2000-2008 (hazard ratio, HR: 0.89; 95% confidence interval, 95% CI: 0.88-0.91, P<0.001), which is consistent with all stages of the tumor.
Conclusions and Relevance:
The incidence of ccRCC increases steadily with the year of diagnosis, with the increase in patients with localized stages accounting for a major part of the increase. In addition, regardless of the stage of the disease, along with the increase in incidence, overall survival has significantly improved.