Characteristics of Critically Ill Patients in ICUs in Mainland China*

Du, Bin; An, Youzhong; Kang, Yan; Yu, Xiangyou; Zhao, Mingyan; Ma, Xiaochun; Ai, Yuhang; Xu, Yuan; Wang, Yushan; Qian, Chuanyun; Wu, Dawei; Sun, Renhua; Li, Shusheng; Hu, Zhenjie; Cao, Xiangyuan; Zhou, Fachun; Jiang, Li; Lin, Jiandong; Chen, Erzhen; Qin, Tiehe; He, Zhenyang; Zhou, Ling

doi:10.1097/ccm.0b013e31826a4082

Cited by 69 publications

(58 citation statements)

References 31 publications

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“…This observation is in line with reports from other studies [5]- [7]. The mean age of the total population was 58.92+13.89 years covering a age ranges from 14 to 102 years while results from different studies revealed lower mean age [5], [8] as well as higher mean age [6], [8], [9]. Table 1 shows that almost fifty three percent of the total population were aged between 40-60 years, 49.61% aged 60years and above and 13.44% between the age group of 20-40 years.…”

Section: Resultssupporting

confidence: 83%

“…Sixty three percent were male while 37 % were female being a ratio of male to female 1:06. This observation is in line with reports from other studies [5]- [7]. The mean age of the total population was 58.92+13.89 years covering a age ranges from 14 to 102 years while results from different studies revealed lower mean age [5], [8] as well as higher mean age [6], [8], [9].…”

Section: Resultssupporting

confidence: 81%

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Demography and Feeding Practices of ICU Patient of Government and Private Hospitals of Jorhat District, Assam

Pl¹,

Ms²,

Gogoi³

2017

IJPHS

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The aim of the present study was to analyze the characteristics and feeding practices of patient admitted to medicine ICUs. All relevant clinical and dietary information were collected for patients admitted to ICUs of selected Government and private hospitals of Jorhat district, Assam. This information was abstracted with the help of pre-structured schedule from the Medical Record Department and Intensive Care Unit team and analysed. A total of 1034 patients were admitted during the study period. Majority of the patients (49.61%) were from the age group of 60years and above. Majority incidence of diseases is a reason of admission in ICUs of both the hospitals was non-communicable diseases and patients were admitted via emergency OPD. Highest length of stay of 10-15 days was observed among the majority of patient from government hospital while it was shorter (6-10 days) for private hospital. The daily feeding pattern of each of the patients was recorded. Patients dependent on homemade blenderized foods for nutritional support were more in Government hospital while compare to the patient using both the commercial formulae as well as homemade food till the last day of stay in private hospitals. Increased cost of hospitalization and better outcome of patient in terms of short stay at hospitals and better nutritional status of the patient admitted to private hospitals were not feasible for low income groups patients admitted in Government hospital. The results of the present study will help the need of formulation and development of patient specific homemade foods with its ingredients used and nutritional requirement in it are taken account for both oral and enteral feedings in the hospitals with higher standard values with all demonstration on the development of protocols for clean techniques in the preparation, safe handling and storage of handmade enteral feeds.

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Section: Resultssupporting

confidence: 83%

Section: Resultssupporting

confidence: 81%

Demography and Feeding Practices of ICU Patient of Government and Private Hospitals of Jorhat District, Assam

Pl¹,

Ms²,

Gogoi³

2017

IJPHS

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show abstract

“…Life Support Withholding and Withdrawing policies were not considered, as well as the discharge to Intermediate Care Units, which may have affected both the percentage of patients who died and the length of stay in the ICU. 35 Although mean APACHE II scores were annually assessed, we assumed that other factors that may influence upon mortality in critically ill patients, 36 such as the number of patients with malignancies or septic complications (septic shock or adult respiratory distress syndrome) did not vary during the study period, although this aspect was not examined. It is also assumed that during the 6-year study period, important changes in the overall care of critically ill patients did not occur, although mortality in some particular groups of patients may have decreased as a consequence of changes in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of patients admitted to Spanish ICU: A prospective observational study from the ENVIN-HELICS registry (2006–2011)

et al. 2016

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“…Severe sepsis can cause multiple organ failure, which has a high mortality [1]. Etomidate is commonly used as an intravenous anaesthetic drug in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Etomidate Mitigates Lipopolysaccharide-Induced CD14 and TREM-1 Expression, NF-κB Activation, and Pro-inflammatory Cytokine Production in Rat Macrophages

et al. 2015

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This study was aimed at investigating the effect of etomidate on the viability of rat macrophages and the function of lipopolysaccharide (LPS)-stimulated macrophages as well as the potential mechanisms. Rat macrophages were isolated and treated with different doses of etomidate for 24 h, and their viability was determined by the CCK-8 assay. Furthermore, macrophages were treated with, or without, 1 μg/ml of LPS, and/or 2.5 or 5 μM etomidate in the presence or absence of a TREM-1 inhibitor (LP17, 100 ng/ml), and the levels of TNF-α, IL-6, CD14, and TREM-1 in the different groups of cells were determined by quantitative RT-PCR, ELISA, and Western blot assays. The levels of NF-κB activation in the different groups of cells were analyzed by an electrophoretic mobility shift assay (EMSA). Etomidate at 31.25 μM or a low dose did not affect the viability of rat macrophages, while etomidate at higher doses reduced the viability of macrophages in vitro. Treatment with 2.5 or 5 μM etomidate or with LP17 alone did not affect the levels of TNF-α, IL-6, CD-14, and TREM-1 in macrophages. Treatment with etomidate significantly mitigated LPS-stimulated TNF-α, IL-6, CD-14, and TREM-1 expression (p < 0.05 for all) and inhibited LPS-induced NF-κB activation in macrophages in vitro. However, treatment with both etomidate and LP17 did not enhance the inhibitory effects in macrophages. Hence, etomidate mitigates LPS-up-regulated pro-inflammatory cytokine production and inhibits LPS-enhanced CD14 and TREM-1 expression and NF-κB activation in macrophages.

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Characteristics of Critically Ill Patients in ICUs in Mainland China*

Abstract: Critically ill patients in ICUs in Mainland China exhibited a case mix similar to those of Western countries, although there are significant differences in intensive care unit admission rates and disease severity between Western and Chinese ICUs.

Cited by 69 publications

References 31 publications

Demography and Feeding Practices of ICU Patient of Government and Private Hospitals of Jorhat District, Assam

Demography and Feeding Practices of ICU Patient of Government and Private Hospitals of Jorhat District, Assam

Characteristics and outcomes of patients admitted to Spanish ICU: A prospective observational study from the ENVIN-HELICS registry (2006–2011)

Etomidate Mitigates Lipopolysaccharide-Induced CD14 and TREM-1 Expression, NF-κB Activation, and Pro-inflammatory Cytokine Production in Rat Macrophages

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