Characteristics of CTX-M Type Extended Spectrum β-lactamase Producing Non-typhoi dal Salmonella Isolates

Park, Soon-Ho; Seo, Yiel-Hea; Ahn, Jeong Yeal; Park, Pil-Hwan; Kim, Kyung‐Hee; Song, Young-Hee; Kim, Jung-Eun

doi:10.3947/ic.2010.42.1.35

Cited by 3 publications

(1 citation statement)

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“…In Korea, a few isolates of TEM-52, CTX-M-14, and CTX-M-15 ESBL-producing Salmonella spp. were detected, of which CTX-M-15 was the most common, followed by CTX-M-14 (13,19,29,30). In the present study, 7 CTX-M-producing Salmonella isolates were identified.…”

Section: Discussionmentioning

confidence: 47%

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

et al. 2013

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SUMMARY:The study aimed to investigate the prevalence of various serotypes and extended-spectrum b-lactamase-producing features of Salmonella strains and to determine the antimicrobial susceptibility of 256 Salmonella strains other than Salmonella serotype Typhi, which were isolated at 12 university hospitals in Korea. We identified 46 serotypes of Salmonella spp. Serogroup D was the most common (39.5z), followed by B (32.4z), C (22.7z), E (2.7z), A (2.3z), and G (0.4z). The three most common Salmonella serotypes were Enteritidis (36.3z), Typhimurium (16.8z), and Infantis (7.8z). Six strains that belonged to serotype Paratyphi A and nine that belonged to serotype Paratyphi B were also detected. The 256 Salmonella strains had a 38.7z rate of resistance to ampicillin, 23.0z to chloramphenicol, 8.2z to cefotaxime, 8.6z to ceftriaxone, and 6.3z to trimethoprim-sulfamethoxazole. The antimicrobial resistance rates of Salmonella serogroups B and D were higher than those of the other serogroups. Seven isolates carried bla CTX-M : four CTX-M-15, two CTX-M-14, and one CTX-M-3.

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Section: Discussionmentioning

confidence: 47%

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

et al. 2013

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Antibiotic Resistance Profiles and Molecular Characteristics ofbla_CTX-M-15-CarryingSalmonella entericaSerovar Enteritidis Isolates from Healthy and Diseased Chickens in Korea

Mechesso

Moon

et al. 2022

Foodborne Pathogens and Disease

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Molecular characterization of antimicrobial resistance in non-typhoidal salmonellae associated with systemic manifestations from India

Menezes

Khan

Harish

et al. 2010

Journal of Medical Microbiology

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Extended-spectrum cephalosporins and fluoroquinolones are essential antimicrobials for treating invasive salmonellosis, although emerging resistance to these antimicrobials is of growing concern, especially in India. Therefore, a study was conducted to characterize the antimicrobial susceptibility phenotypes, types of extended-spectrum b-lactamase (ESBL) gene plasmids and serological relationships of 21 non-typhoidal Salmonella isolates from patients who attended three different hospitals in India from 2006 to 2008. The isolates were cultured from stool, blood and cerebrospinal fluid samples obtained from patients presenting with diarrhoea and accompanying systemic manifestations such as fever, vomiting and meningism. Non-typhoidal Salmonella isolates were investigated using serotyping and antimicrobial susceptibility testing. PCR screening was also performed to detect the b-lactamase, qnr and aac(69)-Ib-cr genes and class 1 integrons. Sequencing for quinolone resistance mutations and plasmid replicon typing were also performed. An antimicrobial resistance microarray was used for preliminary screening and identification of bla TEM and bla SHV genes, and phenotypic testing for the presence of efflux pumps was also performed. Ten out of 21 isolates (48 %) possessed the extended-spectrum cephalosporin resistance phenotype, with PCR amplification and sequencing revealing that isolates possessed TEM-1, SHV-12, DHA-1, OXA-1-like and CTX-M-15 ESBL genes. FII s plasmid replicons were detected in seven isolates (33 %). The involvement of efflux pumps was detected in four isolates (19 %) resistant to ciprofloxacin. It was concluded that SHV-12-carrying Salmonella serotype Agona may play an important role in ESBL-mediated resistance in nontyphoidal salmonellae in India. The very high percentage (48 %) of ESBL-producing non-typhoidal salmonellae isolated from these patients represents a real and immediate challenge to the effective antimicrobial therapy of Salmonella infections associated with systemic manifestations. Continued surveillance for the presence of ESBL-producing (non-typhoidal) salmonellae in India is essential. INTRODUCTIONNon-typhoidal Salmonella is one of the principal pathogens implicated in food-borne gastroenteritis worldwide. In severe infections such as meningitis and septicaemia, antibiotic treatment is essential, with extended-spectrum cephalosporins being used preferentially to treat salmonellosis in children (Threlfall, 2002). However, treatment failures due to the in vivo acquisition of extended-spectrum b-lactamase (ESBL) or fluoroquinolone resistance genes in Salmonella isolates are now well established (Whichard et al., 2007). Salmonella species resistant to extendedspectrum cephalosporins have been known since 1988 (Hammami et al., 1991) Fluoroquinolone resistance is also a growing problem in non-typhoidal salmonellae, with the first report of ciprofloxacin resistance in Salmonella enterica infection (eventually leading to treatment failure) being published in 1990 (Piddock et al., 1990). Sinc...

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Characteristics of CTX-M Type Extended Spectrum β-lactamase Producing Non-typhoi dal Salmonella Isolates

Cited by 3 publications

References 11 publications

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

Antibiotic Resistance Profiles and Molecular Characteristics ofbla_CTX-M-15-CarryingSalmonella entericaSerovar Enteritidis Isolates from Healthy and Diseased Chickens in Korea

Molecular characterization of antimicrobial resistance in non-typhoidal salmonellae associated with systemic manifestations from India

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Characteristics of CTX-M Type Extended Spectrum β-lactamase Producing Non-typhoi dal Salmonella Isolates

Cited by 3 publications

References 11 publications

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

Serotyping and Antimicrobial Susceptibility of <i>Salmonella</i> spp.: Nationwide Multicenter Study in Korea

Antibiotic Resistance Profiles and Molecular Characteristics ofblaCTX-M-15-CarryingSalmonella entericaSerovar Enteritidis Isolates from Healthy and Diseased Chickens in Korea

Molecular characterization of antimicrobial resistance in non-typhoidal salmonellae associated with systemic manifestations from India

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Antibiotic Resistance Profiles and Molecular Characteristics ofbla_CTX-M-15-CarryingSalmonella entericaSerovar Enteritidis Isolates from Healthy and Diseased Chickens in Korea