Characteristics of Early Death in Patients With Localized Nasopharyngeal Cancer: A Population-Based SEER Analysis

Abstract

Localized nasopharyngeal cancer (NPC) is a highly curable disease, but the prognosis of certain cases is still poor. Distinguishing patients with a poor outcome is necessary when developing therapeutic strategies. The aim of this study was to investigate the characteristics of early death (ED) among patients with localized NPC, and to identify independent predictors of ED. Patients diagnosed with localized NPC were included from the Surveillance, Epidemiology, and End Results dataset, and univariate and multivariate logistic regression analyses were performed to identify ED predictors. A total of 752 patients with localized NPC were enrolled, including 198 cases of ED and 480 long-term survivors. Older age, unmarried status, and white race were risk factors for ED, whereas diagnosis in the recent period and undifferentiated non-keratinizing histology type were protective factors. In addition, for older patients, women and those without radiation treatment, there was less ED for married patients than unmarried patients. In conclusion, this population-based study provides an overview of the characteristics of ED patients with localized NPC. Age, race, marital status, year of diagnosis and histology type are risk factors for ED. Moreover, married patients are at a significantly lower risk of ED. This protective effect is especially pronounced in older people, women and those without radiation treatment.

Risk factors of early mortality in patients with small cell lung cancer: a retrospective study in the SEER database

“…Exploring relevant factors can help clinicians identify high-risk patients and develop targeted treatment plans to improve the survival rate and quality of life of patients . Existing evidence has found that risk factors for early death could be identi ed in gastric cancer (Zhu et al 2020), endometrial cancer (Song, Wang, Zhou and Zhang 2020) and nasopharyngeal cancer (Chen et al 2021), but the results on SCLC cases were rarely reported. Therefore, it is practical and necessary to identify risk factors for early death in SCLC.…”

A practical nomogram for predicting early death in elderly small cell lung cancer patients: A SEER-based study

“…In recent years, predictive factors associated with early mortality in malignant tumors such as breast, liver, nasopharyngeal, esophageal, and gastric cancers have been reported. [10][11][12][13][14]19] However, there are fewer studies on early mortality in elderly SCLC patients.…”

“…In contrast, early death (defined as death occurring within 3 months after initial diagnosis) of cancer patients is a very objective clinical feature revealing the aggressiveness of cancer. Researchers have reported predictive factors associated with early death in malignancies such as breast, liver, nasopharyngeal, esophageal, and gastric cancers, [10][11][12][13][14] however, risk factors for early death in elderly SCLC patients remain unreported.…”

An overall survival predictive nomogram to identify high-risk patients among locoregionally advanced nasopharyngeal carcinoma: Developed based on the SEER database and validated institutionally

“…By integrating variables identified to have a significant impact on outcome, nomograms are excellent visualization tools for the estimation of survival rates, but also identify the critical parameters responsible for survival (15). Reported studies examining into some specific subgroups of NPC, including some tumor stage (16)(17)(18)(19)(20)(21)(22), patient age (20,(23)(24)(25)(26), histologic type (27)(28)(29) and even race (30)(31)(32), in a wide scope based on the Surveillance, Epidemiology, and End Results (SEER) data, have shown the potential and ability to provide a better reference for clinical decisions (16,21,23). However, few studies have specifically focused on LA-NPC patients as a group using the SEER data.…”