Characteristics of Early-Onset vs Late-Onset Colorectal Cancer

Collaborative, Reacct; Zaborowski, Alexandra; Abdile, Ahmed; Adamina, Michel; Aigner, Felix; d'Allens, Laura; Allmer, Caterina; Álvarez, Andrea; Anula, Rocío; Andric, Mihailo; Atallah, S.; Bach, Simon; Bala, Miklosh; Barussaud, Marie; Baušys, Augustinas; Bebington, Brendan; Beggs, Andrew D.; Bellolio, Felipe; Bennett, Melissa-Rose; Berdinskikh, Anton; Bevan, Vicki; Biondo, Sebastiano; Bislenghi, Gabriele; Bludau, Marc; Boutall, Adam; Brouwer, Nelleke; Brown, Carl J; Bruns, Christiane; Buchanan, Daniel D.; Buchwald, Pamela; Burger, Jacobus W. A.; Burlov, Nikita; Campanelli, Michela; Capdepont, Maylis; Carvello, Michele; Chew, Hwee-Hoon; Christoforidis, Dimitri; Clark, David; Climent, Marta; Cologne, Kyle G.; Contreras, Tomas; Croner, Roland S.; Daniels, Ian; Dapri, Giovanni; Davies, Justin; Delrio, Paolo; Denost, Quentin; Deutsch, Michael; Dias, André Roncon; D’Hoore, André; Дроздов, Е. С.; Duek, Daniel; Dunlop, Malcolm; Dziki, Adam; Edmundson, Aleksandra; Efetov, Sergey; El‐Hussuna, Alaa; Elliot, Brodie; Emile, Sameh Hany; Espín, Eloy; Evans, Martyn; Faes, Seraina; Faiz, Omar; Fleming, Fergal J.; Foppa, Caterina; Fowler, George E; Frasson, Matteo; Figueiredo, Nuno; Forgan, Tim; Frizelle, Frank; Gadaev, Shamil; Gellona, Jose; Glyn, Tamara; Gong, Jie; Goran, Barisic; Greenwood, Emma; Guren, Marianne Grønlie; Guillon, Stephanie; Gutlic, Ida; Hahnloser, Dieter; Hampel, Heather; Hanly, Ann; Hasegawa, Hirotoshi; Iversen, Lene Hjerrild; Hill, Andrew; Hill, James A.; Hoch, J; Hoffmeister, Michael; Hompes, Roel; Hurtado, Luis A.; Iaquinandi, Fabiano; Imbrasaitė, Ugnė; Islam, Rumana; Jafari, Mehrenah D; Kanemitsu, Yukihide; Карачун, А. М.; Karimuddin, Ahmer; Keller, Deborah S.; Kelly, Justin; Kennelly, Rory; Хрыков, Г. Н.; Kocian, Peter; Koh, Cherry; Kok, Neils; Knight, Katrina; Knol, Joep; Kontovounisios, Christos; Kørner, Hartwig; Krivokapić, Zoran; Kronberger, Irmgard; Kroon, Hidde M.; Kryžauskas, Marius; Kural, S; Kusters, Miranda; Lakkis, Zaher; Lankov, Timur; Larson, D.W.; Lázár, György; Lee, Kai-Yin; Lee, Suk-Hwan; Lefèvre, Jérémie H.; Lepistö, Anna; Lieu, Christopher H.; Loi, Lynette; Lynch, Craig; Maillou‐Martinaud, Helene; Maroli, Annalisa; Martin, Seán T.; Martling, Anna; Matzel, Klaus E.; Mayol, Julio; McDermott, Frank; Meurette, G.; Millán, Mónica; Mitteregger, Martin; Моисеенко, А С; Monson, J. R. T.; Morărașu, Ștefan; Moritani, Konosuke; Möslein, Gabriela; Munini, Martino; Nahas, Caio Sérgio Rizkallah; Nahas, Sérgio Carlos; Negoi, Ionuț; Novikova, Anastasia; Ocares, Misael; Okabayashi, Koji; Olkina, Alexandra; Oñate‐Ocaña, Luis F.; Otero, Jaime; Özen, Cihan; Pace, Ugo; Julião, Guilherme Pagin São; Panaiotti, Lidiia; Panís, Yves; Papamichael, Demetris; Park, Jason; Patel, Swati; Uriburu, Juan C Patrón; Pera, Miguél; Perez, Rodrigo Oliva; Petrov, Alexei; Pfeffer, F.; Phang, P. Terry; Poškus, Tomas; Pringle, Heather; Proud, David; Raguz, Ivana; Rama, N.; Rasheed, Shahnawaz; Raval, Manoj J.; Rega, Daniela; Reißfelder, Christoph; Meneses, Juan Carlos Reyes; Ris, Frédéric; Riss, Stefan; Rodriguez‐Zentner, Homero; Roxburgh, Campbell S.D.; Saklani, Avanish; Salido, Andrea Jiménez; Sammour, Tarik; Saraste, Deborah; Schneider, Martin; Seishima, Ryo; Sekulić, Aleksandar; Seppälä, Toni T.; Sheahan, Kieran; Shine, Rebecca; Shlomina, Alexandra; Sica, Guiseppe S; Singnomklao, Toom; Siragusa, Leandro; Smart, Neil; Solís, Alejandro; Spinelli, Antonino; Staiger, Roxane D; Stamos, Michael J.; Steele, Scott R.; Sunderland, Michael; Tan, Ker‐Kan; Tanis, Pieter J.; Tekkis, Paris; Teklay, Biniam; Tengku, Sabrina; Jiménez-Toscano, Marta; Tsarkov, Petr; Turina, Matthias; Ulrich, Alexis; Vailati, Bruna Borba; Harten, Meike Van; Verhoef, Cornelis; Warrier, Satish; Wexner, S. D.; Wilt, Hans de; Weinberg, Benjamin A.; Wells, Cameron I.; Wolthuis, Albert; Xynos, Evangelos; You, Nancy; Zakharenko, A. A.; Zeballos, Justino; Winter, D. C.

doi:10.1001/jamasurg.2021.2380

Cited by 157 publications

(82 citation statements)

References 74 publications

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“…Colorectal cancer is the frequent cancer globally and has high mortality and incidence rates ( Wieszczy et al, 2020 ; Świerczyński et al, 2021 ; Zaborowski et al, 2021 ; Zhao et al, 2021 ). Bi et al (2020) revealed that LINC01116 was highly expressed in CRC tissues compared to normal tissues, and patients with high expression of LINC01116 had a very poor prognosis.…”

Section: Expression and Clinical Characteristics Of Linc01116 In Various Cancer Typesmentioning

confidence: 99%

Promising Advances in LINC01116 Related to Cancer

Xu¹,

Yu²,

Zhang³

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides that are not translated into proteins. Accumulating evidence indicates that lncRNAs are pivotal regulators of biological processes in several diseases, particularly in several malignant tumors. Long intergenic non-protein coding RNA 1116 (LINC01116) is a lncRNA, whose aberrant expression is correlated with a variety of cancers, including lung cancer, gastric cancer, colorectal cancer, glioma, and osteosarcoma. LINC01116 plays a crucial role in facilitating cell proliferation, invasion, migration, and apoptosis. In addition, numerous studies have recently suggested that LINC01116 has emerged as a novel biomarker for prognosis and therapy in malignant tumors. Consequently, we summarize the clinical significance of LINC01116 associated with biological processes in various tumors and provide a hopeful orientation to guide clinical treatment of various cancers in future studies.

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Section: Expression and Clinical Characteristics Of Linc01116 In Various Cancer Typesmentioning

confidence: 99%

Promising Advances in LINC01116 Related to Cancer

Xu¹,

Yu²,

Zhang³

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Combined efforts in the field of colorectal cancer (CRC) have tremendously advanced the understanding, prognosis and treatment of this deadly disease over the past decades. Main contributors for the overall improved outcome are preventive screening strategies for early detection, as colonoscopy, stool (DNA) analysis and therapeutic options through blood-based biomarkers, personalized treatments and immunotherapy [ 1 , 2 , 3 ]. Though, as of today, alarming and devastating global patterns are being recognized and show themselves in the extensively increasing number of incidences especially in young adults over the past 25 years, ranking CRC still as third (US) and fourth worldwide deadliest cancer entity [ 2 , 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Main contributors for the overall improved outcome are preventive screening strategies for early detection, as colonoscopy, stool (DNA) analysis and therapeutic options through blood-based biomarkers, personalized treatments and immunotherapy [ 1 , 2 , 3 ]. Though, as of today, alarming and devastating global patterns are being recognized and show themselves in the extensively increasing number of incidences especially in young adults over the past 25 years, ranking CRC still as third (US) and fourth worldwide deadliest cancer entity [ 2 , 4 , 5 , 6 , 7 , 8 ]. The mortality, morbidity and early onset of CRC are expected to increase even further and main contributors to this development are not entirely understood, though hypothesized to root in changed lifestyle habits, such as smoking, diet, alcohol and obesity [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid Metabolism Interplay in CRC—An Update

2022

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Colorectal cancer (CRC) to date still ranks as one of the deadliest cancer entities globally, and despite recent advances, the incidence in young adolescents is dramatically increasing. Lipid metabolism has recently received increased attention as a crucial element for multiple aspects of carcinogenesis and our knowledge of the underlying mechanisms is steadily growing. However, the mechanism how fatty acid metabolism contributes to CRC is still not understood in detail. In this review, we aim to summarize our vastly growing comprehension and the accompanied complexity of cellular fatty acid metabolism in CRC by describing inputs and outputs of intracellular free fatty acid pools and how these contribute to cancer initiation, disease progression and metastasis. We highlight how different lipid pathways can contribute to the aggressiveness of tumors and affect the prognosis of patients. Furthermore, we focus on the role of lipid metabolism in cell communication and interplay within the tumor microenvironment (TME) and beyond. Understanding these interactions in depth might lead to the discovery of novel markers and new therapeutic interventions for CRC. Finally, we discuss the crucial role of fatty acid metabolism as new targetable gatekeeper in colorectal cancer.

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“…As described, there is compelling evidence that EOCRC and LOCRC are distinct entities [ 38 ], varying regarding genetic predisposition, location, histopathology, molecular classification and the presence of more advanced disease and poorer outcome for EOCRC. As opposed to LOCRC, younger patients frequently present with disease in the distal colon and rectum with multiple lesions and unfavorable histology [ 45 ]. The poorer outcome in EOCRC is in part due to the absence, until recently, of a risk-based screening and surveillance strategy for those individuals younger than 50 years of age.…”

Section: Introductionmentioning

confidence: 99%

Early Onset Colorectal Cancer: An Emerging Cancer Risk in Patients with Diamond Blackfan Anemia

Lipton

Molmenti

Desai

et al. 2021

Genes

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Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome, the founding member of a class of disorders known as ribosomopathies. Most cases result from loss of function mutations or deletions in 1 of 23 genes encoding either a small or large subunit-associated ribosomal protein (RP), resulting in RP haploinsufficiency. DBA is characterized by red cell hypoplasia or aplasia, poor linear growth and congenital anomalies. Small case series and case reports demonstrate DBA to be a cancer predisposition syndrome. Recent analyses from the Diamond Blackfan Anemia Registry of North America (DBAR) have quantified the cancer risk in DBA. These studies reveal the most prevalent solid tumor, presenting in young adults and in children and adolescents, to be colorectal cancer (CRC) and osteogenic sarcoma, respectively. Of concern is that these cancers are typically detected at an advanced stage in patients who, because of their constitutional bone marrow failure, may not tolerate full-dose chemotherapy. Thus, the inability to provide optimal therapy contributes to poor outcomes. CRC screening in individuals over the age of 50 years, and now 45 years, has led to early detection and significant improvements in outcomes for non-DBA patients with CRC. These screening and surveillance strategies have been adapted to detect familial early onset CRC. With the recognition of DBA as a moderately penetrant cancer risk syndrome a rational screening and surveillance strategy will be implemented. The downstream molecular events, resulting from RP haploinsufficiency and leading to cancer, are the subject of significant scientific inquiry.

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Characteristics of Early-Onset vs Late-Onset Colorectal Cancer

Cited by 157 publications

References 74 publications

Promising Advances in LINC01116 Related to Cancer

Promising Advances in LINC01116 Related to Cancer

Lipid Metabolism Interplay in CRC—An Update

Early Onset Colorectal Cancer: An Emerging Cancer Risk in Patients with Diamond Blackfan Anemia

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