2020
DOI: 10.1093/cid/ciaa1331
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Characteristics of Ebola Virus Disease Survivor Blood and Semen in Liberia: Serology and Reverse Transcription Polymerase Chain Reaction (RT-PCR)

Abstract: Introduction Ebola virus (EBOV), species Zaire ebolavirus, may persist in the semen of male survivors of Ebola Virus Disease (EVD). We conducted a study of male survivors of the 2014-2016 EVD outbreak in Liberia and evaluated their immune responses to EBOV. We report here findings from the serologic testing of blood for EBOV-specific antibodies, molecular testing for EBOV in blood and semen, and serologic testing of peripheral blood mononuclear cells (PBMCs) in a subset of study participants … Show more

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Cited by 7 publications
(1 citation statement)
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“…EBOV is believed to persist specifically in immune-privileged sites, including the eye, brain, and testes. This persistence is evident in various bodily fluids after recovery, with a comprehensive record, particularly in semen, breast milk, and aqueous humor (14,15,(43)(44)(45)(46)(47). The detectability of EBOV RNA in skin swabs up to 23 days after viral clearance, despite concurrent negative cell culture results, indicates its enduring presence (48).…”
Section: Viral Persistence and Reactivation In Survivorsmentioning
confidence: 99%
“…EBOV is believed to persist specifically in immune-privileged sites, including the eye, brain, and testes. This persistence is evident in various bodily fluids after recovery, with a comprehensive record, particularly in semen, breast milk, and aqueous humor (14,15,(43)(44)(45)(46)(47). The detectability of EBOV RNA in skin swabs up to 23 days after viral clearance, despite concurrent negative cell culture results, indicates its enduring presence (48).…”
Section: Viral Persistence and Reactivation In Survivorsmentioning
confidence: 99%