Characteristics of Epstein‐Barr virus isolated from the malignant lymphomas in Korea

Kim, Insun; Park, Eui Ryun; Park, Seol Hee; Lin, Zhenhua; Kim, Young Sik

doi:10.1002/jmv.2193

Cited by 14 publications

(14 citation statements)

References 43 publications

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“…0.05). Similar to our results, the f variant was rare in other areas, such as Japan, Korea, Europe, North America, South America and Africa ignoring the source (healthy donors and malignant patients) [10,11,24,27,30,31] . In addition, the F variant was dominant in patients with other EBV-associated diseases (18/19 T cell lymphoma, 3/3 infectious mononucleosis and 37/45 EBV-associated gastric carcinoma) in Southern China [22] , whereas the f variant was only prevalent in NPC of Southern China.…”

Section: Discussionsupporting

confidence: 79%

“…A high prevalence of EBV type A was identified in 24/25 NPC patients from Guangdong, 37/45 NPC patients from Guangxi and 25/30 NPC patients from Taiwan, all belonging to the Southern China, endemic area of NPC [18,21,22] . Type A is also the prevalent strain in human malignancies in other Asian countries, such as Malaysia, Japan, and Korea [11,23,24] . Generally, type B was reported to prevail in Africa and Alaskan Eskimos [3,19] .…”

Section: Discussionmentioning

confidence: 99%

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Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern China

Cui

Wang²,

Liu³

et al. 2010

Intervirology

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Objectives: To characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Northern China, and to explore the relationship between the EBV genotypes and NPC. Methods: The genotypes of EBV strains were analyzed by the polymerase chain reaction and restriction fragment length polymorphism. Results: The predominant EBV type was A, C or F in both NPC and healthy individuals. The distributions of the EBV subtypes between NPC and healthy donors were not significantly different (p > 0.05). The frequency of type f strains in NPC was significantly lower in Northern China than in Southern China. Conclusions: No evidence of special EBV genotypes associated with NPC was found, suggesting that EBV strains derived from the NPC patients may reflect geographic distribution rather than being NPC restricted.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern China

Cui

Wang²,

Liu³

et al. 2010

Intervirology

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“…In Slovenian patients with NPC, genotype C was identified in 31 out of 103 EBV positive samples and genotype D in 72. Specifically in tumor biopsies, the incidence of genotype C was 37.5% (18/48), which places Slovenia between China with almost 100% prevalence of genotype C on the one side and Africa, America, and Korea, where only EBV genotype D was found, on the other side [Lung et al, 1994;Sidagis et al, 1997;Henry et al, 2001;Kim et al, 2002]. These results point to the possible geographical distribution of specific EBV genotypes.…”

Section: Discussionmentioning

confidence: 67%

“…As in the case of genotype f, genotype C was at first believed to be associated with NPC, especially in China. Both were found in as much as 95-100% of tumor biopsy specimens from the patients with NPC [Lung and Chang, 1992;Lung et al, 1994;Kim et al, 2002]. In Slovenian patients with NPC, genotype C was identified in 31 out of 103 EBV positive samples and genotype D in 72.…”

Section: Discussionmentioning

confidence: 91%

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Distribution of Epstein–Barr virus genotypes in throat washings, sera, peripheral blood lymphocytes and in EBV positive tumor biopsies from Slovenian patients with nasopharyngeal carcinoma

Klemenc¹,

Marin²,

Šoba

et al. 2006

J. Med. Virol.

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Nasopharyngeal carcinoma (NPC) is a malignancy closely associated with Epstein-Barr virus (EBV). It is prevalent among the Chinese of Southern China, whereas outside China, the position seems to be different. The aim of this study was to determine the distribution of EBV genotypes in the patients with NPC in Slovenia, which is a nonendemic area. Detection of EBV was undertaken by testing the throat washes, sera, peripheral blood lymphocytes (PBLs), and biopsies of primary tumors of 48 patients with NPC in Slovenia. The sera of 20 patients with serologically confirmed primary EBV infection served as a control clinical material. The analysis of genotypes was carried out on three regions of EBV genome; BamHI WYH, BamHI I, and BamHI F, using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The results show that, in Slovenia, the predominant combination of EBV genotypes based on the differences in the three genomic regions is ADF. This combination was found in 56 out of 103 different EBV positive clinical samples (throat washes, sera, PBLs, and tumor biopsies) of patients with NPC and in 15 out of 17 sera of patients with primary EBV infection. Very low number of genotypes C and f were detected, in spite of the fact that these two genotypes were considered to be associated with the development and/or maintenance of NPC in Southern China. Genotype f was found in only two tumor biopsies; in all other clinical samples (throat washes, sera and PBLs), genotype F was detected. Genotype C was proven in 31/103 clinical samples, with the highest percentage in tumor biopsies (37.5%). As in the NPC patients from other countries (Alaska is an exception), genotype A was predominant and was detected in 86/103 clinical samples. Genotype B was found in 15 clinical samples of patients with NPC and in 3 the two genotypes A and B were found. In comparison to China, these results show different EBV genotypes distribution. It seems that the genetic disposition of human population is an important factor that may contribute to different susceptibility for specific EBV genotypes.

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Epstein–Barr virus strains and variations: Geographic or disease‐specific variants?

Neves

Marinho‐Dias

Ribeiro

et al. 2016

Journal of Medical Virology

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The Epstein-Barr Virus (EBV) is associated with the development of several diseases, including infectious mononucleosis (IM), Burkitt's Lymphoma (BL), Nasopharyngeal Carcinoma, and other neoplasias. The publication of EBV genome 1984 led to several studies regarding the identification of different viral strains. Currently, EBV is divided into EBV type 1 (B95-8 strain) and EBV type 2 (AG876 strain), also known as type A and type B, which have been distinguished based upon genetic differences in the Epstein-Barr nuclear antigens (EBNAs) sequence. Several other EBV strains have been described in the past 10 years considering variations on EBV genome, and many have attempted to clarify if these variations are ethnic or geographically correlated, or if they are disease related. Indeed, there is an increasing interest to describe possible specific disease associations, with emphasis on different malignancies. These studies aim to clarify if these variations are ethnic or geographically correlated, or if they are disease related, thus being important to characterize the epidemiologic genetic distribution of EBV strains on our population. Here, we review the current knowledge on the different EBV strains and variants and its association with different diseases. J. Med. Virol. 89:373-387, 2017. © 2016 Wiley Periodicals, Inc.

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Characteristics of Epstein‐Barr virus isolated from the malignant lymphomas in Korea

Cited by 14 publications

References 43 publications

Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern China

Genotypic Analysis of Epstein-Barr Virus Isolates Associated with Nasopharyngeal Carcinoma in Northern China

Distribution of Epstein–Barr virus genotypes in throat washings, sera, peripheral blood lymphocytes and in EBV positive tumor biopsies from Slovenian patients with nasopharyngeal carcinoma

Epstein–Barr virus strains and variations: Geographic or disease‐specific variants?

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