Characteristics of false-positive lesions in evaluating colorectal liver metastases on gadoxetic acid-enhanced magnetic resonance imaging

Yamada, Shuhei; Kishi, Yoji; Miyake, Makito; Nara, Satoshi; Esaki, Minoru; Shimada, Kazuaki

doi:10.1007/s00595-022-02451-5

Cited by 2 publications

(50 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following the whole-body 18 F-FDG PET/CT imaging, dedicated liver 18 F-FDG PET/MR images were obtained in the same session. PET/MRI was performed with a simultaneous PET/MRI system (3 T., SIGNA PET/MR, GE Healthcare) with dedicated liver MRI protocol.…”

Section: Liver Pet/mri Protocol and Image Analysismentioning

confidence: 99%

“…While pathologic FDG uptake was not seen in 137/139 lesions (TN), two lesions with FDG uptake were confirmed as benign according to gold standard (FP). Although these two FP lesions were seen in two patients, one patient was considered FP, another patient was not considered FP for patient-based analysis as metastatic lesions were detected by MRI and 18 F-FDG PET/MRI in different liver segments. The sensitivity, specificity and accuracy of 18 F-FDG PET/CT in the detection of liver metastases were calculated as 55.6, 98.5 and 70.7%, respectively.…”

Section: Pet/computed Tomography Findingsmentioning

confidence: 99%

“…The sensitivity, specificity and accuracy of 18 F-FDG PET/MRI in the detection of liver metastases were calculated as 97.2, 100 and 98.2%, respectively. The classification of 18 F-FDG PET/CT, 18 F-FDG PET/ MRI and MRI findings according to the gold standard on lesion and patient-based analysis is given in Table 2.…”

Section: Pet/mri Findingsmentioning

confidence: 99%

“…2). In the remaining 10 patients, 18 F-FDG PET/CT imaging was an FN, while 18 F-FDG PET/MRI defined patients as TP (Fig. 3).…”

mentioning

confidence: 99%

“…In these patients, instead of decision to follow up without treatment, surgical resection/locoregional treatment was performed. In two of seven patients, while one or two metastatic lesions were seen on 18 F-FDG PET/ CT, multiple metastatic lesions were detected with 18 F-FDG PET/MRI, and it was decided to apply systemic chemotherapy instead of surgical resection or locoregional treatment for these patients. Changes in clinical approach between pre-PET CI + 18 F-FDG PET/CT and 18 F-FDG PET/MRI findings are shown in Table 6.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Clinical value of fluorine-18–fluorodeoxyglucose PET/MRI for liver metastasis in colorectal cancer: a prospective study

Gunduz¹,

Özkan²,

Öz³

et al. 2022

Nuclear Medicine Communications

View full text Add to dashboard Cite

Purpose To evaluate the diagnostic performance of liver 18F-FDG PET/MRI in addition to whole-body PET/CT and to compare it with MRI in the detection and clinical management of liver metastasis in patients with colorectal cancer (CRC). Material and methods Seventy-eight patients with CRC who underwent whole-body 18F-FDG PET/CT followed by liver PET/MRI were prospectively included. Histopathological confirmation and/or at least 3 months of clinical follow-up after PET/MRI were accepted as gold standard. Lesion and patient-based analyses were performed to evaluate the diagnostics performances of PET/CT, PET/MRI and MRI. In addition, changes of clinical management were evaluated. Results On lesion-based analysis, for PET/CT, PET/MRI and MRI; sensitivity (Se): 55.6%, 97.2% and 100%; specificity (Sp): 98.5%, 100% and 80.5%; and accuracy (Acc): 70.7%, 98.2% and 93.1% were calculated, respectively. Se and Acc of PET/MRI and MRI were significantly superior than PET/CT (P < 0.001). Se and Acc of PET/MRI and MRI were comparable; however, Sp of PET/MRI was significantly better than MRI (P < 0.001). On patient-based analysis, Se: 75.6%, 100% and 100%; Sp: 97.3%, 100% and 86.5%; and Acc: 85.9%, 100% and 93.5% were calculated, respectively. Se and Acc of PET/MRI were significantly superior than PET/CT (P < 0.001). Also, Se of MRI was significantly superior than PET/CT (P < 0.001). Se of PET/MRI and MRI were comparable, but Sp and Acc of PET/MRI were significantly better than MRI. The additional information obtained from liver PET/MRI changed treatment strategy in 14/78 (18%) patients compared to PET/CT or alone liver MRI. Conclusion Diagnostic performances of PET/MRI and MRI for detection of CRC liver metastasis is superior to PET/CT. PET/MRI especially helps in the accurate detection of liver metastases that are suspicious on MRI and has the potential to change the clinical management of especially oligometastatic patients by identifying uncertain liver lesions.

show abstract

Section: Liver Pet/mri Protocol and Image Analysismentioning

confidence: 99%

Section: Pet/computed Tomography Findingsmentioning

confidence: 99%

Section: Pet/mri Findingsmentioning

confidence: 99%

“…2). In the remaining 10 patients, 18 F-FDG PET/CT imaging was an FN, while 18 F-FDG PET/MRI defined patients as TP (Fig. 3).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Clinical value of fluorine-18–fluorodeoxyglucose PET/MRI for liver metastasis in colorectal cancer: a prospective study

Gunduz¹,

Özkan²,

Öz³

et al. 2022

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment

Ryu,

Kim,

et al. 2024

Ann Coloproctol

View full text Add to dashboard Cite

Colorectal cancer is the third most common cancer in Korea and the third leading cause of death from cancer. Treatment outcomes for colon cancer are steadily improving due to national health screening programs with advances in diagnostic methods, surgical techniques, and therapeutic agents.. The Korea Colon Cancer Multidisciplinary (KCCM) Committee intends to provide professionals who treat colon cancer with the most up-to-date, evidence-based practice guidelines to improve outcomes and help them make decisions that reflect their patients’ values and preferences. These guidelines have been established by consensus reached by the KCCM Guideline Committee based on a systematic literature review and evidence synthesis and by considering the national health insurance system in real clinical practice settings. Each recommendation is presented with a recommendation strength and level of evidence based on the consensus of the committee.

show abstract

Characteristics of false-positive lesions in evaluating colorectal liver metastases on gadoxetic acid-enhanced magnetic resonance imaging

Cited by 2 publications

References 22 publications

Clinical value of fluorine-18–fluorodeoxyglucose PET/MRI for liver metastasis in colorectal cancer: a prospective study

Clinical value of fluorine-18–fluorodeoxyglucose PET/MRI for liver metastasis in colorectal cancer: a prospective study

Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment

Contact Info

Product

Resources

About