Characteristics of Focal Gamma Zone Parapapillary Atrophy

Kim, Hae Rang; Weinreb, Robert N.; Zangwill, Linda M.; Suh, Min Hee

doi:10.1167/iovs.61.3.17

Cited by 16 publications

(13 citation statements)

References 34 publications

(75 reference statements)

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“…The presence of gamma-zone was also reported in patients with glaucoma, 11 describing two subtypes of gamma-zone : the conventional gamma-zone involves the axis fovea—Bruch's membrane opening, whereas the focal gamma-zone does not involve the above-mentioned axis. This distinction was correlated with different clinical features: focal gamma-zone was associated with older age, shorter axial length, and smaller beta-zone in comparison with eyes with conventional gamma-zone .…”

Section: Ppa In Glaucomatous Optic Neuropathymentioning

confidence: 85%

“…This distinction was correlated with different clinical features: focal gamma-zone was associated with older age, shorter axial length, and smaller beta-zone in comparison with eyes with conventional gamma-zone . 11 In addition, eyes with focal gamma-zone also demonstrated more defects of lamina cribrosa than eyes with conventional gamma-zone and eyes without it. 11…”

Section: Ppa In Glaucomatous Optic Neuropathymentioning

confidence: 96%

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Parapapillary atrophy in optic neuropathies: Histology and clinical relevance

Banc

Marzoli

2021

European Journal of Ophthalmology

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Parapapillary atrophy is one of the parameters of the optic nerve head area which are assessed during the ophthalmoscopic examination particularly useful to characterize glaucomatous optic neuropathy. Optical coherence tomography evaluation provides high-resolution images of the optic nerve head and surrounding area, and can be used to study parapapillary atrophy. Different parapapillary atrophy zones were described depending on their histological features and research has been conducted to investigate the possible association between the presence and/ or size of parapapillary atrophy zones and several optic nerve disorders. In this review we discuss the histology and the clinical findings related to parapapillary atrophy in patients with glaucomatous optic neuropathy, non-glaucomatous optic neuropathies (e.g. arteritic and non-arteritic anterior ischemic optic neuropathies; suprasellar and parasellar tumors), and other ocular conditions (e.g. high myopia; age-related macular degeneration). Two different histologic classifications were identified. Parapapillary atrophy was demonstrated in glaucoma and glaucoma-like neuropathies, but not in other types of optic nerve disorders.

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Section: Ppa In Glaucomatous Optic Neuropathymentioning

confidence: 85%

Section: Ppa In Glaucomatous Optic Neuropathymentioning

confidence: 96%

Parapapillary atrophy in optic neuropathies: Histology and clinical relevance

Banc

Marzoli

2021

European Journal of Ophthalmology

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“…Furthermore, the correlation between parapapillary deep vasculature dropout and decreased peripapillary choroidal thickness was present only in the POAG eyes with a γ-zone (85). Eyes with focal γ-parapapillary atrophy localized to the inferior or superior hemi-retina had shorter axial lengths, smaller Bruch's membrane opening areas and higher prevalence of focal LC defects (86).…”

Section: Parapapillary Choroidal Microvasculature In β-Zone and γ-Zone Parapaillary Atrophymentioning

confidence: 94%

Optical coherence tomography angiography in glaucoma

Fard¹,

Ritch²

2020

Ann Transl Med

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Assessment of the vasculature within the optic nerve, peripapillary superficial retina, macula, and peripapillary choroid can be determined in glaucoma using optical coherence tomography angiography (OCTA). Decreased perfusion within the pre-laminar layer of the optic nerve has been correlated with glaucoma severity. The peripapillary superficial retinal vessel density allows diagnosis and detection of glaucoma progression in a manner similar to the peripapillary retinal nerve fiber layer (RNFL) thickness.Furthermore, decreased peripapillary vessel density of the intact hemiretina or unaffected eye of glaucomatous eyes suggests that vascular changes can occur prior to detectable visual field damage. The accuracy for glaucoma detection of the macular ganglion cell (MGC) thickness compared to macular vessel density has differed among studies. Several studies have reported reduction of macular vessel density as well as its ganglion cell thickness. Results of studies evaluating the parapapillary choroid have shown a greater prevalence of choroidal microvasculature dropout in glaucomatous eyes with a parapapillary gamma zone,which is associated with central visual field defects or glaucoma progression. It remains unclear whether the reduced vessel density in glaucoma is a primary event or secondary to glaucomatous damage. Further studies are warranted to elucidate this question.

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“… 16 Focal gamma zone has been reported to be related to glaucoma development, while the conventional gamma zone is not. 17 …”

Section: Introductionmentioning

confidence: 99%

“…16 Focal gamma zone has been reported to be related to glaucoma development, while the conventional gamma zone is not. 17 Ophthalmoscopically, peripapillary crescent is peripapillary changes touching a part of the disc circumference, typically observed on the horizontal temporal peripapillary area. On the other hand, when peripapillary retinal changes surround the optic nerve head, we call it a peripapillary halo.…”

Section: Introductionmentioning

confidence: 99%

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

Khodeiry¹,

Liu²,

Sayed³

et al. 2021

OPTH

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Purpose Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR). Patients and Methods This was a prospective observational case-series in a single tertiary referral center. Six eyes of three patients with PPH associated with BSCR were determined through clinical examination, fundus photography, and fundus autofluorescence (FAF). Patients underwent swept-source optical coherence tomography (SS-OCT) imaging of the optic nerve head and peripapillary region. Results In SS-OCT B-scans across the area of PPH, we observed thinning and interruption of retinal pigment epithelium (RPE)-Bruch’s membrane complex. These halos are a circumferential form of alpha zone RPE-associated crescentic peripapillary atrophy (PPA), unlike the PPH observed with myopia and normal aging. Conclusion PPH in BSCR patients may be a sign of prior inflammatory optic neuropathy.

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Characteristics of Focal Gamma Zone Parapapillary Atrophy

Cited by 16 publications

References 34 publications

Parapapillary atrophy in optic neuropathies: Histology and clinical relevance

Parapapillary atrophy in optic neuropathies: Histology and clinical relevance

Optical coherence tomography angiography in glaucoma

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

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