Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort

Abstract

When strictly defined, FVPTC in pediatric patients has a low risk for bilateral disease and metastasis. Prospective studies are needed to confirm whether lobectomy with surveillance is sufficient to achieve remission in pediatric patients with low-risk FVPTC.

Molecular Alterations in Relation to Histopathological Characteristics in a Large Series of Pediatric Papillary Thyroid Carcinoma from a Single Institution

“…Furthermore, 36 out of 163 PTCs (22.1%) showed areas of solid/trabecular growth; these findings are not unusual in pediatric PTCs [17]. Samuels reported a series of 18 pediatric FV-PTCs and four tumors (22%) presented a mixed follicular-solid/trabecular pattern [21]. Interestingly, in our PTC series, tumors with solid areas were significantly enriched in gene rearrangements.…”

Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review

“…All previously reported cases in the English literature (n = 12) were included for comparison (total n = 15). 18–21 Based on available data of the 15 cases, majority were female (69%) and aged from 9 to17 years at the time of diagnosis. Tumor size ranged from 0.4 to 3.1 cm, with an average of 1.8 cm.…”

“…12,13,16,17 However, studies describing the tumor characteristics and behavior of NIFTP in the pediatric population are scant, with only a total of 12 cases reported in the literature. 18–21 It is not clear if the experience of NIFTP derived from studies predominantly in adult patients can be equally applied to children, given the clinicopathologic differences between PTC in adult and pediatric patients.…”

Case Report: Multifocal non-invasive follicular thyroid neoplasm with papillary-like nuclear features presenting in a female child

“…NIFTP cytology was commonly interpreted as follicular lesion of undetermined significance in 30% (categories III and IV according to Bethesda system), follicular neoplasm in 21%, suspicious for malignancy in 24%, malignant in 8%, bnign in 10% and non-diagnostic in 3% 11 , 12 . Although the above findings would suggest lobectomy, our patient was submitted for total thyroidectomy and as has been done in previously reported cases 6 , 7 , 9 , 10 .…”

“…Most NIFTP cases have been previously reported in adults and data concerning this diagnosis in children is scarce; only 21 cases in children have been reported in the English literature within the last two years ( Table 1 ) 6 – 10 . Preoperative diagnosis of our case was based on ultrasound data and the cytology was not obviously malignant.…”