Characteristics of gastric cancer gut microbiome according to tumor stage and age segmentation

Chen, Changchang; Du, Yaoqiang; Liu, Yanxin; Shi, Yongkang; Niu, Yaofang; Jin, Gulei; Shen, Jian; Lyu, Jianxin; Lin, Lijun

doi:10.1007/s00253-022-12156-x

Cited by 9 publications

(8 citation statements)

References 48 publications

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“…95 Collinsella, Blautia, Anaerostipes and Dorea are more abundant in patients with advanced GC than in those with early GC. 96 Moreover, increased risk of vessel carcinoma emboli was observed in patients with GC with a higher abundance of Methylobacterium, Oceanobacter and Syntrophomonas. 18 Firmicutes is also enriched in faecal samples of patients with GC with lymph node metastasis.…”

Section: Predictive Microbial Biomarkersmentioning

confidence: 99%

Stomach microbiota in gastric cancer development and clinical implications

Zeng,

Gou,

Lau

et al. 2024

Gut

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Gastric cancer (GC) is one of the most common malignancies and a prominent cause of cancer mortality worldwide. A distinctive characteristic of GC is its intimate association with commensal microbial community. AlthoughHelicobacter pyloriis widely recognised as an inciting factor of the onset of gastric carcinogenesis, increasing evidence has indicated the substantial involvement of microbes that reside in the gastric mucosa during disease progression. In particular, dysregulation in gastric microbiota could play pivotal roles throughout the whole carcinogenic processes, from the development of precancerous lesions to gastric malignancy. Here, current understanding of the gastric microbiota in GC development is summarised. Potential translational and clinical implications of using gastric microbes for GC diagnosis, prognosis and therapeutics are also evaluated, with further discussion on conceptual haziness and limitations at present. Finally, we highlight that modulating microbes is a novel and promising frontier for the prevention and management of GC, which necessitates future in-depth investigations.

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Section: Predictive Microbial Biomarkersmentioning

confidence: 99%

Stomach microbiota in gastric cancer development and clinical implications

Zeng,

Gou,

Lau

et al. 2024

Gut

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“… 19 , 25 , 122 , 123 , 164 , 186–188 Although there are limited data published on the relationship between the microbiome and early-onset digestive system cancers, studies have suggested differences in the microbiome of stool specimens or tumor tissue between early-onset and later-onset gastrointestinal cancers ( Table 3 ). 189–191 , 193 …”

Section: Microbiome and Digestive System Tumor Developmentmentioning

confidence: 99%

“… Cancer type Findings (Reference) Gastric cancer The amounts of Streptococcus , Veillonella , Tyzzerella , and Aggregatibacter were increased, while the amounts of Odoribacter and Eubacterium ventriosum were decreased in fecal specimens from patients with early-onset gastric cancer compared to age-matched healthy individuals. 189 Colorectal cancer Diversity and composition of gut microbiome are significantly different between patients with early-onset and late-onset colorectal cancer. Some specific bacterial genera, such as Veillonella , Odoribacter , Flavonifractor , Actinomyces , Porphyromonas , or Fusobacterium , were enriched in fecal specimens from patients with early-onset colorectal cancer compared to age-matched healthy individuals.…”

Section: Microbiome and Digestive System Tumor Developmentmentioning

confidence: 99%

“…The amounts of Streptococcus , Veillonella , Tyzzerella , and Aggregatibacter were increased, while the amounts of Odoribacter and Eubacterium ventriosum were decreased in fecal specimens from patients with early-onset gastric cancer compared to age-matched healthy individuals. 189 …”

Section: Microbiome and Digestive System Tumor Developmentmentioning

confidence: 99%

“…Chen et al have performed 16S rRNA gene sequencing of fecal specimens from 196 patients with gastric cancer and 30 healthy individuals in China, and showed that the amounts of Streptococcus , Veillonella , Tyzzerella , and Aggregatibacter were increased, while those of Odoribacter and Eubacterium ventriosum were lower in stools of early-onset gastric cancer patients than those of age-matched healthy individuals. 189 Virome analyses by Liu et al have demonstrated a blood-based viral exposure signature to predict the occurrence of HCC, and suggested pathogenic roles of viruses other than hepatitis B virus and hepatitis C virus in the development of HCC. 193 Further studies are needed to clarify exact mechanisms underlying these associations of the microbiome with early-onset digestive system cancers.…”

Section: Microbiome and Digestive System Tumor Developmentmentioning

confidence: 99%

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The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

Mima,

Hamada,

Inamura

et al. 2023

Gut Microbes

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Accumulating evidence indicates an alarming increase in the incidence of early-onset cancers, which are diagnosed among adults under 50 years of age, in the colorectum, esophagus, extrahepatic bile duct, gallbladder, liver, stomach, pancreas, as well as the bone marrow (multiple myeloma), breast, head and neck, kidney, prostate, thyroid, and uterine corpus (endometrium). While the early-onset cancer studies have encompassed research on the wide variety of organs, this article focuses on research on digestive system cancers. While a minority of early-onset cancers in the digestive system are associated with cancer-predisposing high penetrance germline genetic variants, the majority of those cancers are sporadic and multifactorial. Although potential etiological roles of diets, lifestyle, environment, and the microbiome from early life to adulthood (i.e. in one’s life course) have been hypothesized, exact contribution of each of these factors remains uncertain. Diets, lifestyle patterns, and environmental exposures have been shown to alter the oral and intestinal microbiome. To address the rising trend of early-onset cancers, transdisciplinary research approaches including lifecourse epidemiology and molecular pathological epidemiology frameworks, nutritional and environmental sciences, multi-omics technologies, etc. are needed. We review current evidence and discuss emerging research opportunities, which can improve our understanding of their etiologies and help us design better strategies for prevention and treatment to reduce the cancer burden in populations.

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