This study examined the holistic grief effects of Black female college students. A total of 105 participants from two universities, who identified as Black or African American females, completed a questionnaire regarding death losses and grief effects they experienced. Descriptive statistics and ANOVAs examined between-group differences based on loss experiences. Linear regressions predicted the grief effects Black female college students experience based on time since loss and cause of death. Participants displayed holistic grief effects in all six dimensions of cognitive, emotional, behavioral, physical, interpersonal, and spiritual/world assumptions, with emotional and cognitive effects as the most experienced grief effects. The cause of death had a statistically significant effect on grief effects with suicide and murder, displaying higher mean effects. Although statistically significant relationships were not found between grief effects and time of loss, most mean effects peaked at 7–12 months post-loss. Implications and recommendations for future research are provided.