a b s t r a c tThe combined measurement of dark matter interactions with different superheated liquids has recently been suggested as a cross-correlation technique in identifying WIMP candidates. We describe the fabrication of high concentration superheated droplet detectors based on the light nuclei liquids C 3 F 8 , C 4 F 8 , C 4 F 10 and CCl 2 F 2 , and investigation of their irradiation response with respect to C 2 ClF 5 . The results are discussed in terms of the basic physics of superheated liquid response to particle interactions, as well as the necessary detector qualifications for application in dark matter search investigations. The possibility of heavier nuclei SDDs is explored using the light nuclei results as a basis, with CF 3 I provided as an example.