The city of East St. Louis, IL, has a history of abundant industrial activities including smelters of ferrous and nonferrous metals, a coal-fired power plant, companies that produce organic and inorganic chemicals, and petroleum refineries. A protocol for soil analysis was developed to produce sufficient information on the extent of heavy metal contamination in East St. Louis soils. Soil cores representing every borough of East St. Louis were analyzed for heavy metals-As, Cd, Cu, Cr, Hg, Ni, Pb, Sb, Sn, and Zn.