Characteristics of high frame frequency contrast-enhanced ultrasound in renal tumors

Zhang, WeiPing; Wang, JingLing; Chen, Li

doi:10.1186/s12880-024-01245-0

Cited by 2 publications

(5 citation statements)

References 28 publications

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“…Compared to contrast-enhanced CT, CEUS is more sensitive due to its strong inhibition of background tissue. This makes it possible to distinguish solid oligovascular masses from atypical cystic masses and easier to visualize septa and enhancing solid elements [2,13]. CEUS can identify more septa, provide a better assessment of their thickness, and more frequently detect solid components within cystic lesions [14].…”

Section: Application Of Ceusmentioning

confidence: 99%

“…In the case of a small, richly vascularized tumor, the perfusion process in the arterial phase of CEUS is very fast. Consequently, it is difficult to accurately identify the tumor perfusion process and blood vessel morphology, which limits diagnostic effectiveness [2].…”

Section: Application Of Ceusmentioning

confidence: 99%

“…Compared to current CEUS, which uses a frequency of 10-15 Hz, the frequency of H-CEUS is increased to 50-80 Hz. This allows the adverse effects of low frame rate on the temporal resolution of contrast images to be ameliorated to some extent, thereby providing more diagnostic information [2,13]. When it comes to the kidney, CEUS focuses on the renal cortex and medulla within the region of interest (ROI), obtaining renal microcirculatory perfusion parameters from a perfusion curve model based on intensity-over-time data [15].…”

Section: Application Of Ceusmentioning

confidence: 99%

“…Statistics indicate that solid masses are a significant minority in the number of all diagnosed renal lesions, but they comprise 90% of solid renal tumors that are malignant [16]. Statistically, about 70% of renal malignancies are RCC [2]. It is the most lethal malignant neoplasm of the genitourinary system, which originates in the tubular epithelium of the renal parenchyma [17].…”

Section: Solid Renal Lesions In Ceusmentioning

confidence: 99%

“…The availability of imaging methods has enabled increased detection of kidney lesions, which are a common clinical problem [1]. It is estimated that more than half of patients over the age of 50 have at least one undetermined mass in the kidney [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Contrast-Enhanced Ultrasound in the Diagnosis of Solid Renal Lesions

Zbroja,

Kuczyńska,

Drelich

et al. 2024

JCM

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The availability of imaging methods has enabled increased detection of kidney lesions, which are a common clinical problem. It is estimated that more than half of patients over the age of 50 have at least one undetermined mass in the kidney. The appropriate characterization and diagnosis of lesions imaged in the kidney allows for proper therapeutic management. Previously, contrast-enhanced computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) have been used in their extended diagnosis. However, the limitations of these techniques, such as radiation exposure, renal toxicity, and allergies to contrast agents, must be considered. Contrast-enhanced ultrasound (CEUS) is increasingly being used as an examination to resolve interpretive doubts that arise with other diagnostic methods. Indeed, it can be considered both as a problem-solving technique for diagnosing and distinguishing lesions and as a technique used for observation in preservative treatment. Evaluation of the enhancement curve over time on CEUS examination can help to differentiate malignant renal cell carcinoma (RCC) subtypes that should be resected from benign lesions, such as oncocytoma or angiomyolipoma (AML), in which surgery can be avoided. It allows for distinguishing between benign and malignant tumors, renal and pseudotumors, and solid and cystic tumors. Therefore, with recent advances in ultrasound technology, CEUS has emerged as a fast, reliable, and cost-effective imaging tool in the preoperative evaluation and diagnosis of solid renal masses.

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Section: Application Of Ceusmentioning

confidence: 99%

Section: Application Of Ceusmentioning

confidence: 99%

Section: Application Of Ceusmentioning

confidence: 99%

Section: Solid Renal Lesions In Ceusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contrast-Enhanced Ultrasound in the Diagnosis of Solid Renal Lesions

Zbroja,

Kuczyńska,

Drelich

et al. 2024

JCM

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Qualitative and quantitative analysis of solid renal tumors by high-frame-rate contrast-enhanced ultrasound

Wu,

Shi,

Gao

et al. 2024

Cancer Imaging

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Objective To analyze the characteristics of high-frame-rate contrast-enhanced ultrasound (H-CEUS) in solid renal tumors using qualitative and quantitative methods. Methods Seventy-five patients who underwent preoperative conventional ultrasound (US), conventional contrast-enhanced ultrasound (C-CEUS), and H-CEUS examination of renal tumors were retrospectively analyzed, with a total of 89 renal masses. The masses were divided into the benign (30 masses) and malignant groups (59 masses) based on the results of enhanced computer tomography and pathology. The location, diameter, shape, border, calcification, and color doppler blood flow imaging (CDFI) of the lesions were observed by US, and the characteristics of the C-CEUS and H-CEUS images were qualitatively and quantitatively analyzed. The χ² test or Fisher’s exact probability method was used to compare the US image characteristics between the benign and malignant groups, and the image characteristics of C-CEUS and H-CEUS between the benign and malignant groups. Moreover, the nonparametric Mann-Whitney test was used to compare the differences in C-CEUS and H-CEUS time-intensity curve (TIC) parameters. Results Significant differences in gender, surgical approach, echogenicity, and CDFI were observed between the malignant and benign groups (p = 0.003, < 0.001, < 0.001, = 0003). Qualitative analysis also revealed significant differences in the mode of wash-out and fill-in direction between C-CEUS and H-CEUS in the malignant group (p = 0.041, 0.002). In addition, the homogeneity of enhancement showed significant differences between the two contrast models in the benign group (p = 0.009). Quantitative analysis indicated that the TIC parameters peak intensity (PI), deceleration time (DT) /2, area under the curve (AUC), and mean transition time (MTT) were significantly lower in the H-CEUS model compared to the C-CEUS model in both the benign and malignant groups. (all p < 0.001). In contrast, ascending slope of rise curve (AS) was significantly higher in the H-CEUS model compared to the C-CEUS model in the malignant group (p = 0.048). Conclusions In renal tumors, H-CEUS shows clearer internal enhancement of the mass and the changes in the wash-out period. The quantitative TIC parameters PI, DT/2, AUC, and MTT were lower in H-CEUS compared to C-CEUS. Both the quantitative and qualitative analyses indicated that H-CEUS better displays the characteristics of solid renal masses compared with C-CEUS.

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Characteristics of high frame frequency contrast-enhanced ultrasound in renal tumors

Cited by 2 publications

References 28 publications

Contrast-Enhanced Ultrasound in the Diagnosis of Solid Renal Lesions

Contrast-Enhanced Ultrasound in the Diagnosis of Solid Renal Lesions

Qualitative and quantitative analysis of solid renal tumors by high-frame-rate contrast-enhanced ultrasound

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