Characteristics of hospitalised COVID‐19 patients and parameters associated with severe pneumonia

Turan, Onur; Mirici, Arzu; Akcali, Serap; Turan, Pakize Ayşe; Batum, Özgür; Şengül, Aysun; Ünsal, Zühal Ekici; Kabakoğlu, Nalan Işık; Ogan, Nalan; Torun, Şerife; Ak, Güntülü; Akçay, Şule; Kömürcüoğlu, Berna; Şen, Nazan; Mutlu, Pınar; Yılmaz, Ülkü

doi:10.1111/ijcp.14786

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…However, when patients with severe COVID-19 were grouped separately, it was observed that the mean age increased to 60.3 and the male sex ratio increased to 60%. Our mean age in the patients we followed up after severe and critical COVID-19 is similar to Turan et al's study [21].…”

Section: Discussionsupporting

confidence: 88%

Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes

et al. 2021

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This study aimed to detect patients' characteristics who suffered severe and critical COVID-19 pneumonia admitted to the post-acute COVID-19 rehabilitation clinic in Ankara City Hospital, Physical Medicine and Rehabilitation Hospital and to share our experiences and outcomes of rehabilitation programmes applied. This study was designed as a single-centre, retrospective, observational study. Severe and critical COVID-19 patients, admitted to the post-acute COVID-19 rehabilitation clinic, were included in patient-based rehabilitation programmes, targeting neuromuscular and respiratory recovery. Functional status, oxygen (O 2 ) requirement and daily living activities were assessed before and after rehabilitation. Eightyfive patients, of which 74% were male, were analysed, with the mean age of 58.27 ± 11.13 and mean body mass index of 25.29 ± 4.81 kg/m 2 . The most prevalent comorbidities were hypertension (49.4%) and diabetes mellitus (34.1%). Of the 85 patients, 84 received antiviral drugs, 81 low-molecular-weight heparin, 71 corticosteroids, 11 anakinra, 4 tocilizumab, 16 intravenous immunoglobulin and 6 plasmapheresis. 78.8% of the patients were admitted to the intensive care unit, with a mean length of stay of 19.41 ± 18.99 days, while those who needed O 2 support with mechanic ventilation was 36.1%. Neurological complications, including Guillain-Barré syndrome, critical illness-related myopathy/neuropathy, cerebrovascular disease and steroid myopathy, were observed in 39 patients. On initial functional statuses, 55.3% were bedridden, 22.4% in wheelchair level and 20% mobilised with O 2 support. After rehabilitation, these ratios were 2.4%, 4.7% and 8.2%, respectively. During admission, 71 (83.5%) patients required O 2 support, but decreased to 7 (8.2%) post-rehabilitation. Barthel Index improved statistically from 44.82 ± 27.31 to 88.47 ± 17.56. Patient-based modulated rehabilitation programmes are highly effective in severe and critical COVID-19 complications, providing satisfactory well-being in daily living activities.

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Section: Discussionsupporting

confidence: 88%

Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes

et al. 2021

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“…The study cohort reflects the well described characteristics of hospitalised patients with COVID-19, with a male dominance, middle-aged and older individuals, presence of co-morbidities such as CVD, chronic pulmonary disease, obesity, and diabetes (56)(57)(58). Although these conditions are known risk factors for severe COVID-19, somewhat surprisingly, we did not find a significant association of co-morbidities, besides obesity, with disease severity.…”

Section: Discussionmentioning

confidence: 60%

Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19

et al. 2021

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Background: Efficient healthcare based on prognostic variables in hospitalised patients with COVID-19 could reduce the risk of complications and death. Recently, soluble urokinase Plasminogen Activator Receptor (suPAR) was shown to predict respiratory failure, kidney injury, and clinical outcome in patients with SARS-CoV-2 infection. The aim of this study was to investigate the value of suPAR as a prognostic tool, in comparison with other variables, regarding disease severity and length of hospital stay in patients with COVID-19.Patients and Methods: Individuals hospitalised with COVID-19 (40 males, 20 females; median age 57.5 years) with a median symptom duration of 10 days and matched, healthy controls (n = 30) were included. Admission levels of suPAR were measured in serum by enzyme-linked immunosorbent assay. Blood cell counts, C-reactive protein (CRP) levels, lactate dehydrogenase (LDH), plasma creatinine and estimated glomerular filtration rates were analysed and oxygen demand, level of care and length of hospitalisation recorded.Results: Patients had significantly higher suPAR levels compared to controls (P < 0.001). Levels were higher in severely/critically (median 6.6 ng/mL) compared with moderately ill patients (median 5.0 ng/mL; P = 0.002). In addition, suPAR levels correlated with length of hospitalisation (rho = 0.35; P = 0.006). Besides suPAR, LDH, CRP, neutrophil count, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratio, body mass index and chronic renal failure were discriminators of COVID-19 severity and/or predictors of length of hospitalisation.Conclusion: Admission levels of suPAR were higher in patients who developed severe/critical COVID-19 and associated with length of hospital stay. In addition, we showed that suPAR functioned as an independent predictor of COVID-19 disease severity.

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“…The results of various studies have shown a link between values of blood factors with high blood pressure [ 29 – 31 ] and COVID-19 [ 32 ]. Meanwhile, these factors can be considered as predictors of hypertension [ 33 ] or severity of COVID-19 [ 34 ]. Among these, we can mention the inflammatory factors such as C-reactive protein (CRP) that have been shown to be associated with both hypertension and COVID-19 disease [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of antihypertensive medications on severity and outcomes of hypertensive patients with COVID-19

et al. 2022

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In Covid-19 pandemic, specific comorbidities are associated with the increased risk of worse outcomes and increased severity of lung injury and mortality. the aim of this study was to investigate the effects of antihypertensive medications on the severity and outcomes of hypertensive patients with COVID-19. This retrospective observational study conducted on patients with COVID-19 who referred to Afzalipour Hospital, Kerman, Iran during the six months from 19 February 2020 to 20 July 2020. The data were collected through medical chart reviews. We assessed 265 patients with Covid-19 and they stratified based on hypertension and type of antihypertension medications. The data were described and Student’s t -test, Mann–Whitney U and Fisher exact test were run to compare the patients ‘demographical and clinical information. The qualitative variables were compared using the by SPSS software version 23. The results of the present study showed that hypertension was a prevalent comorbidity among patients with COVID-19 and hypertensive patients compared to other patients without any comorbidity who were older ( P -value: 0.03). The oxygen saturation was higher for the patients in the control group than hypertensive patients ( P -value: 0.01). The severity of COVID-19 and its outcome were not different between the patients who took or did not take antihypertensive medications and also the type of antihypertensive medications. Hypertensive patients did not show any significant difference in survival, hospital stay, ICU admission, disease severity, and invasive medical ventilation in other normotensive patients with COVID-19.

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Characteristics of hospitalised COVID‐19 patients and parameters associated with severe pneumonia

Abstract: All the authors are members of Turkish Respiratory Society (TRS).

Cited by 9 publications

References 22 publications

Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes

Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes

Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19

The effects of antihypertensive medications on severity and outcomes of hypertensive patients with COVID-19

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