Characteristics of hyperuricemia in older adults in China and possible associations with sarcopenia

Xu, Zhu-An; Zhang, Qin; Chen, Lu-Fang; Xu, Keying; Xia, Jiaying; Li, Shumin; Yang, Yunmei

doi:10.1002/agm2.12004

Cited by 13 publications

(14 citation statements)

References 35 publications

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“…We also observed that skeletal muscle index and grip strength were positively associated with UA level. This finding is consistent with those of previous cross-sectional studies in the elderly [31][32][33]. UA is the final product of purine metabolism.…”

Section: Discussionsupporting

confidence: 93%

Associations between Health-Related Physical Fitness and Cardiovascular Disease Risk Factors in Overweight and Obese University Staff

Chen

Zhou

Pan

et al. 2020

IJERPH

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Purpose: This cross-sectional study examined the associations between health-related physical fitness (HPF) and cardiovascular disease (CVD) risk factors in overweight and obese university staff. Methods: A total of 340 university staff (109 women, mean age 43.1 ± 9.7years) with overweight (n = 284) and obesity (n = 56) were included. The HPF indicators included skeletal muscle mass index (SMI), body fat percentage (BFP), grip strength (GS), sit-and-reach test (SRT), and vital capacity index (VCI). CVD risk factors were measured, including uric acid (UA), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and glucose (GLU). Results: BFP, SMI, and GS were positively associated with UA level (β = 0.239, β = 0.159, β = 0.139, p < 0.05). BFP was positively associated with TG and TG/HDL-C levels (β = 0.421, β = 0.259, p < 0.05). GS was positively associated with HDL-C level (β = 0.244, p < 0.05). SRT was negatively associated with GLU level (β = −0.130, p < 0.05). Conclusions: In overweight and obese university staff, body composition, muscle strength, and flexibility were associated with CVD risk factors. An HPF test may be a practical nonmedical method to assess CVD risk.

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Section: Discussionsupporting

confidence: 93%

Associations between Health-Related Physical Fitness and Cardiovascular Disease Risk Factors in Overweight and Obese University Staff

Chen

Zhou

Pan

et al. 2020

IJERPH

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“…Conversely, higher UA level was found to have no relationship with physical performance which was assessed using Short Physical Performance Battery (SPPB) scale in another two cross-sectional study 16,17 . This might be explained by the reason that SPPB is a nal sum of multiple parameters that included walking speed over 4 meters, ve timed repeated chair rises and standing balance.…”

Section: Discussionmentioning

confidence: 90%

“…One study showed that an inverted J-shaped association between serum UA levels and HGS in both genders among Chinese adults aged over 45 5 . Another study in China showed that higher uric acid levels were signi cantly correlated with higher muscle mass, grip strength in 388 participants aged over 60 16 . Besides, study in Japan found an inverted J-shaped association between the serum UA quartiles and muscle strength in 630 male Japanese employees aged over 30 years old 8 .…”

Section: Discussionmentioning

confidence: 99%

Higher Uric Acid Serum Levels Are Associated With Sarcopenia In West China: Results From The WCHAT Study

Chen

Hou

et al. 2021

Preprint

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Background: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study. Methods: 4236 adults aged 50 years or older in communities of west China were enrolled in this study. We applied AWGS 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS) and gait speed (GS) were recorded, respectively. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected.Results: Participants were grouped according to UA quartiles by gender. After adjusting for potential confounders, a significant association between serum UA levels and sarcopenia was shown both in men and women. And a significant association between serum UA levels and HGS in women was shown as a inverted J shape. Besides, the association between the UA quartiles and SMI was significant, irrespective of gender.Conclusions: Our results showed that a specific range of serum UA levels might be associated with sarcopenia and better HGS or SMI among Chinese adults aged over 50. Higher UA serum levels might slow down the progression of sarcopenia.

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“…Uric acid is an enzymatic waste endproduct from the degradation of purine nucleosides that is renally excreted. Uric acid plays both protective and damaging roles in the skeletal muscles [ 39 ], most likely due to its strong antioxidant properties at low levels and pro-inflammatory effect at high levels [ 35 ]. It has been proposed that oxidative stress might contribute to muscle weakness and wasting.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years

et al. 2022

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Background Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). The aim of this study was to identify the baseline metabolomic signatures for the longitudinal reduction of muscle strength over 10 years in the well-established community-based Tasmanian Older Adult Cohort (TASOAC). Methods Study participants were 50–79 year old individuals from the TASOAC. Hand grip, knee extension, and leg strength were measured at baseline, 2.6-, 5-, and 10-year follow-up points. Fasting serum samples were collected at 2.6-year follow-up point, and metabolomic profiling was performed using the TMIC Prime Metabolomics Profiling Assay. Generalized linear mixed effects model was used to identify metabolites that were associated with the reduction in muscle strength over 10 years after controlling for age, sex, and BMI. Significance level was defined at α=0.0004 after correction of multiple testing of 129 metabolites with Bonferroni method. Further, a genome-wide association study (GWAS) analysis was performed to explore if genetic factors account for the association between the identified metabolomic markers and the longitudinal reduction of muscle strength over 10 years. Results A total of 409 older adults (50% of them females) were included. The mean age was 60.93±6.50 years, and mean BMI was 27.12±4.18 kg/m2 at baseline. Muscle strength declined by 0.09 psi, 0.02 kg, and 2.57 kg per year for hand grip, knee extension, and leg strength, respectively. Among the 143 metabolites measured, 129 passed the quality checks and were included in the analysis. We found that the elevated blood level of asymmetric dimethylarginine (ADMA) was associated with the reduction in hand grip (p=0.0003) and knee extension strength (p=0.008) over 10 years. GWAS analysis found that a SNP rs1125718 adjacent to WISP1gene was associated with ADMA levels (p=4.39*10-8). Further, we found that the increased serum concentration of uric acid was significantly associated with the decline in leg strength over 10 years (p=0.0001). Conclusion Our results demonstrated that elevated serum ADMA and uric acid at baseline were associated with age-dependent muscle strength reduction. They might be novel targets to prevent muscle strength loss over time.

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Characteristics of hyperuricemia in older adults in China and possible associations with sarcopenia

Cited by 13 publications

References 35 publications

Associations between Health-Related Physical Fitness and Cardiovascular Disease Risk Factors in Overweight and Obese University Staff

Associations between Health-Related Physical Fitness and Cardiovascular Disease Risk Factors in Overweight and Obese University Staff

Higher Uric Acid Serum Levels Are Associated With Sarcopenia In West China: Results From The WCHAT Study

Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years

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