Characteristics of images of angiographically proven normal coronary arteries acquired by adenosine-stress thallium-201 myocardial perfusion SPECT/CT-IQ⋅SPECT with CT attenuation correction changed stepwise

Takahashi, Teruyuki; Tanaka, Haruki; Kozono, Nami; Tanakamaru, Yoshiki; Idei, Naomi; Ohashi, Norihiko; Ohtsubo, Hideki; Okada, Takenori; Yasunobu, Yuji; Kaseda, Shunichi

doi:10.1007/s12149-014-0935-5

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…Although the 12 s/view protocol has been validated, future studies comparing the shortened acquisition protocol with angiographic findings are warranted. However, there is increasing evidence of high diagnostic accuracy of the IQ-SPECT system also in comparison with coronary angiography [21]. The lack of a significant effect on the quantitative measurements when the 6 s/view acquisition was employed allows greater confidence in the measurements, which is important for the translation of these results to clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of one-eighth time gated myocardial perfusion SPECT functional imaging using IQ-SPECT

Caobelli

Thackeray

Soffientini

et al. 2015

Eur J Nucl Med Mol Imaging

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Section: Discussionmentioning

confidence: 99%

Feasibility of one-eighth time gated myocardial perfusion SPECT functional imaging using IQ-SPECT

Caobelli

Thackeray

Soffientini

et al. 2015

Eur J Nucl Med Mol Imaging

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“…The pooled specificities across the studies were 0.78 (95% CI, 0.71-0.83), 0.82 (0.75-0.86), 0.74 (0.62-0.83), and 0.58 (0.48-0.67) for all AC, CTAC, RAC, and all NAC, respectively, when diagnosing CAD at a patient level; 0.81 (0.75-0.86), 0.82 (0.72-0.89), 0.80 (0.76-0.84), and 0.79 (0.70-0.85) for all AC, CTAC, RAC, and all NAC when detecting LAD stenosis; 0.91 (0.83-0.95), 0.89 (0.76-0.96), 0.92 (0.83-0.96), and 0.86 (0.76-0.92) for all AC, CTAC, RAC, and all NAC when detecting LCX stenosis; and 0.87 (0.82-0.91), 0.88 (0.79-0.93), 0.87 (0.82-0.90), and 0.61 (0.51-0.71) for all AC, CTAC, RAC, and all NAC when detecting RCA stenosis. The pooled DORs, which are regarded as being minimally affected by verification bias, were 16 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), 15 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), 16 , and 8 (6-12) for all AC, CTAC, RAC, and all NAC, respectively, when diagnosing CAD at a patient level; 13 (9-20)s, 15 (9-26), 11 (6-21), and 9 (6-13) for all AC, CTAC, RAC, and all NAC when detecting LAD stenosis; 18 (10-32), 15 , 20 , and 11 (6-20) for all AC, CTAC, RAC, and all NAC when detecting LCX stenosis; and 18 (11-29), 18 (9-36), 19 (10-37), and 7 (5-10) for all AC, CTAC, RAC, and all NAC when detecting RCA stenosis.…”

Section: Diagnostic Performancementioning

confidence: 99%

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

Huang

Yen

et al. 2021

Front. Cardiovasc. Med.

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Background: The aim of this study was to determine whether, and if so how, attenuation correction (AC) improves the diagnostic performance of myocardial perfusion imaging (MPI) in different coronary artery-supplied territories, using coronary angiography as the reference standard.Methods: PubMed and EMBASE were searched until December 2020 for studies evaluating AC MPI for the diagnosis of coronary artery disease (CAD) with vessel-based data. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. For each study, the sensitivity, specificity, diagnostic odds ratios and areas under summary receiver operating characteristic curves (AUC) with 95% confidence intervals were calculated to determine the diagnostic accuracy of AC compared to non-AC MPI. A bivariate mixed-effects model was used to pool the data. Subgroup analyses considering the type of radiotracer and type of AC were performed.Results: A total of 264 articles were screened, of which 22 studies (2,608 patients) were enrolled. Significant improvements in specificity [0.78 vs. 0.58 in overall CAD, 0.87 vs. 0.61 in right coronary artery (RCA)] and diagnostic odds ratios (16 vs. 8 in overall CAD, 18 vs. 7 in RCA) after AC were shown in overall CAD at a patient level and RCA stenosis. Improvements in AUC were also noted. MPI had a similar diagnostic performance for detecting left anterior descending and left circumflex coronary artery stenosis with or without AC. There were trends of decreased sensitivity after AC, but none were significant. Diagnostic odds ratio showed significant improvement after AC only in the technetium-99m subgroup.Conclusion: The results of this study suggest that AC should be applied to MPI to improve the diagnosis of CAD regardless of which type of radiotracer, and that AC MPI can improve the specificity of detecting RCA stenosis.

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“…To recognize normal subjects as definitively normal has a practical value in patients suspected of having CAD. The key point for correctly interpreting normal myocardial images obtained with IQ·SPECT is to understand the characteristic findings of the apex, apical anterior and inferolateral walls of the left ventricle [ 20 – 22 ]. In the CTAC images, the apical counts are frequently decreased even in normal subjects (Fig.…”

Section: Iq·spect Images In Normal Subjectsmentioning

confidence: 99%

IQ·SPECT technology and its clinical applications using multicenter normal databases

et al. 2017

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IQ·SPECT (Siemens Medical Solutions) is a solution for high-sensitivity and short-time acquisition imaging of the heart for a variable angle general purpose gamma camera. It consists of a multi-focal collimator, a cardio-centric orbit and advanced iterative reconstruction, modeling the image formation physics accurately. The multi-focal collimator enables distance-dependent enlargement of the center region while avoiding truncation at the edges. With the specified configuration and a cardio-centric orbit it can obtain a fourfold sensitivity increase for the heart at the center of the scan orbit. Since IQ·SPECT shows characteristic distribution patterns in the myocardium, appropriate acquisition and processing conditions are required, and normal databases are convenient for quantification of both normal and abnormal perfusion images. The use of prone imaging can be a good option when X-ray computed tomography (CT) is not available for attenuation correction. CT-based attenuation correction changes count distribution significantly in the inferior wall and around the apex, hence image interpretation training and additional use of normal databases are recommended. Recent reports regarding its technology, Japanese Society of Nuclear Medicine working group activities, and clinical studies using 201Tl and 99mTc-perfusion tracers in Japan are summarized.

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Characteristics of images of angiographically proven normal coronary arteries acquired by adenosine-stress thallium-201 myocardial perfusion SPECT/CT-IQ⋅SPECT with CT attenuation correction changed stepwise

Cited by 8 publications

References 32 publications

Feasibility of one-eighth time gated myocardial perfusion SPECT functional imaging using IQ-SPECT

Feasibility of one-eighth time gated myocardial perfusion SPECT functional imaging using IQ-SPECT

Diagnostic Effect of Attenuation Correction in Myocardial Perfusion Imaging in Different Coronary Arteries: A Systematic Review and Meta-Analysis

IQ·SPECT technology and its clinical applications using multicenter normal databases

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