Characteristics of immune memory 10–15 years after primary hepatitis B vaccination

Hummel, Irena Brunskole; Zitzmann, A; Erl, Monika; Wenzel, Jürgen J.; Jilg, Wolfgang

doi:10.1016/j.vaccine.2015.12.033

Cited by 18 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different definitions and timepoints have been used to measure the anamnestic response to a challenge dose. An HBsAg vaccine challenge has been shown to induce a typical anamnestic response with a steep increase starting between 3 and 7 days postchallenge, peaking around 14 days and plateauing between 14 days and 1 month . This is consistent with results from our study which show an initial increase in anti‐HBs concentrations 7 days postchallenge (with an 84.2% anamnestic response rate) and a further increase 30 days postchallenge.…”

Section: Discussionsupporting

confidence: 92%

“…Despite low frequencies of HBsAg‐specific CD4 + T cells in venous blood 20‐30 years after primary vaccination, the observed increase as early as 7 days after the HBsAg vaccine challenge indicates a memory recall. Previous studies have assessed long‐term persistence of memory B and CD4 + T cells and the cellular immune response to a challenge up to 32 years after priming in adults, infants or children . However, there was substantial heterogeneity in the assays and timepoints used for assessment; therefore, it is hard to compare results.…”

Section: Discussionmentioning

confidence: 99%

“…B‐ and T‐cell‐mediated immune memory confers long‐term protection after waning of vaccine‐induced antibodies against HBsAg (anti‐HBs) . Different methods have been used to assess long‐term HBV protection, including measuring the anamnestic response to a challenge dose, in vitro testing for B‐ and T‐cell activation, or measuring the infection rate in vaccinated populations after extended follow‐up …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Persistence of HBsAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults

Damme

Dionne

Leroux‐Roels

et al. 2019

Journal of Viral Hepatitis

View full text Add to dashboard Cite

The duration of protection after hepatitis B vaccination is not exactly known. This phase IV study evaluated antibody persistence and immune memory 20‐30 years after adult immunization with recombinant hepatitis B vaccine (HBsAg vaccine, Engerix‐B) in routine clinical practice. Men and women 40‐60 years old, with documented evidence of vaccination with three or four HBsAg vaccine doses 20‐30 years earlier and without subsequent booster, were enrolled and received HBsAg vaccine as challenge dose. HBsAg‐specific antibodies (anti‐HBs) and frequencies of HBsAg‐specific circulating memory B cells and CD4+ T cells expressing combinations of activation markers (CD40L, IL2, IFNγ, TNFα) were measured prechallenge, 7 and 30 days postchallenge. Of 101 participants in the according‐to‐protocol cohort for immunogenicity, 90.1% had anti‐HBs concentrations ≥ 10 mIU/mL prechallenge administration; 84.2% and 100% mounted an anamnestic response 7 and 30 days postchallenge, respectively. HBsAg‐specific memory B and CD4+ T cells expressing at least two activation markers were low prechallenge and increased markedly postchallenge. These results suggest sustained immune memory and long‐term protection 20‐30 years after a complete primary HBsAg vaccination course during adulthood, in line with current recommendations that a booster is not needed in fully vaccinated immunocompetent adults.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Persistence of HBsAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults

Damme

Dionne

Leroux‐Roels

et al. 2019

Journal of Viral Hepatitis

View full text Add to dashboard Cite

show abstract

“…It is well established in literature that HBsAb can provide long-term protection in a general healthy population 20 – 22 . The protective role of HBsAb in clearance of circulating HBsAg and suppression of HBV replication was also reported.…”

Section: Discussionmentioning

confidence: 99%

Use of ELISpot assay to study HBs-specific B cell responses in vaccinated and HBV infected humans

Tian

Chen

Liu

et al. 2018

Emerging Microbes & Infections

View full text Add to dashboard Cite

Hepatitis B surface antibody (HBsAb) plays a critical role in protecting against infection of hepatitis B virus (HBV) and were extensively studied in literature. At the same time, the status of hepatitis B surface antigen (HBs)-specific B cells in both vaccinated and HBV infected people received limited attention. In the current study, we adopted a highly specific B-cell Enzyme Linked ImmunoSpot (ELISpot) assay to analyze HBs-specific B cells in various clinical settings: healthy individuals with the history of HBV vaccination before and after receiving an extra HBV vaccine boost, people chronically infected with HBV (CHB) in various clinical stages, with or without a particular type anti-viral treatment, or whether receiving a dose of HBV vaccine. In all of these cases, B-cell ELISpot assay was used effectively in enumerating the frequency of HBs-specific B cells. While the focus of the current report was to establish the utility of this assay for HBV research, a number of interesting observations were made in this pilot study based on the profiles and dynamics of HBs-specific B cells in various conditions. Such information is useful to guide the future work in designing novel therapeutic strategies against CHB.

show abstract

“…Se conoce que la inmunidad contra el VHB es regulada por factores genéticos del hospedero, como las variantes alélicas de SNP de genes de la respuesta inmune y la expresión de ARNm de IFN-γ (4,9). La distribución de la frecuencia de alelos de IL-12A e IL-12B SNP fue similar a la identificada en los pacientes de Polonia y de Taiwán (10,11).…”

Section: Discussionunclassified

Papel del polimorfismo de un simple nucleótido de la interleucina 12 y la expresión de IFN-gamma en la respuesta de anticuerpos a la vacuna recombinante contra el virus de la hepatitis B

et al. 2019

View full text Add to dashboard Cite

Introducción. Los factores genéticos del hospedero; como el polimorfismo de genes de citocinas influyen en la magnitud de la respuesta de anti-HBs inducida tras la vacunación contra el virus de la hepatitis B.Objetivos. Determinar si el polimorfismo de un simple nucleótido (SNP) de los genes de la interleucina 12 (IL12) A y B, influyen en la respuesta humoral a la vacuna Heberbiovac HB.Material y Métodos. Se estudiaron 12 trabajadores de la salud que no tenían niveles protectores de anti-HBs y fueron reactivados con una dosis de Heberbiovac HB. Las variantes de SNP de IL12A rs568408 e IL12B rs3212227 se identificaron por secuenciación nucleotídica. Se empleó el UMELISA anti-HBs para cuantificar los niveles de anti-HBs a los 7 y 28 días posteriores a la vacunación (dpv).Resultados. Altos niveles de anti-HBs (>1000UI/L) fueron detectados en el 75% (9/12) de los trabajadores a los 28dpv. Las combinaciones de IL12A rs568408/IL12B rs3212227 asociadas con una mayor respuesta de anti-HBs fueron la GG/AC y AG/AC. Bajos niveles protectores de anti-HBs (<13 UI/L) fue detectada a los 28 dpv, en un individuo que portaba la combinación AA/AA.Conclusión. La variabilidad genética entre individuos debe tenerse en cuenta para inducir una elevada seroprotección, en personas que reciban una dosis de reactivación con Heberbiovac HB.

show abstract

Characteristics of immune memory 10–15 years after primary hepatitis B vaccination

Abstract: The presence of B cell memory could be shown by a typical anamnestic anti-HBs response curve after a booster dose in all but one individual. In contrast, T cell responses to booster vaccination, which occurred in approximately 50% of participants, were rather heterogeneous.

Cited by 18 publications

References 39 publications

Persistence of HBsAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults

Persistence of HBsAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults

Use of ELISpot assay to study HBs-specific B cell responses in vaccinated and HBV infected humans

Papel del polimorfismo de un simple nucleótido de la interleucina 12 y la expresión de IFN-gamma en la respuesta de anticuerpos a la vacuna recombinante contra el virus de la hepatitis B

Contact Info

Product

Resources

About