Characteristics of Incidentally Discovered Thyroid Cancer

Yoo, Frederick; Chaikhoutdinov, Irina; Mitzner, Ron; Liao, Jason; Goldenberg, David

doi:10.1001/jamaoto.2013.5050

Cited by 30 publications

(26 citation statements)

References 28 publications

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“…8 11 Some investigators have, however, questioned the idea that overdiagnosis is the main cause of the current notable increase in cases of thyroid cancer. [12][13][14] In a registry based cancer study, 12 investigators observed that the incidence of both small and large thyroid tumours and the incidence of intrathyroidal and extrathyroidal cancers 12 substantially increased from 1983 to 2006 in the United States. The researchers concluded that improved detection does not fully explain…”

Section: Introductionmentioning

confidence: 99%

Association between screening and the thyroid cancer “epidemic” in South Korea: evidence from a nationwide study

Park

Cho

et al. 2016

BMJ

194

173

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Objective To investigate whether screening for thyroid cancer led to the current “epidemic” in South Korea.Design Review of the medical records of nationally representative samples of patients with a diagnosis of thyroid cancer in 1999, 2005, and 2008.Setting Sample cases were randomly selected from South Korea’s nationwide cancer registry, using a systematic sampling method after stratification by region.Participants 5796 patients with thyroid cancer were included (891 in 1999, 2355 in 2005, and 2550 in 2008).Main outcome measures The primary outcome was age standardised incidence of thyroid cancer and the changes in incidence between 1999 and 2008 according to the methods used to detect tumours (screen detection versus clinical detection versus unspecified).Results Between 1999 and 2008, the incidence of thyroid cancer increased 6.4-fold (95% confidence interval 4.9-fold to 8.4-fold), from 6.4 (95% confidence interval 6.2 to 6.6) per 100 000 population to 40.7 (40.2 to 41.2) per 100 000 population. Of the increase, 94.4% (34.4 per 100 000 population) were for tumours less than 20 mm, which were detected mainly by screening. 97.1% of the total increase was localised and regional tumours according to the Surveillance, Epidemiology, and End Results (SEER) summary stage. Where cases were clinically detected, 99.9% of the increased incidences (6.4 per 100 000 population) over the same period were tumours less than 20 mm.Conclusion The current “epidemic” of thyroid cancer in South Korea is due to an increase in the detection of small tumours, most likely as a result of overdetection. Concerted efforts are needed at a national level to reduce unnecessary thyroid ultrasound examinations in the asymptomatic general population.

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Section: Introductionmentioning

confidence: 99%

Association between screening and the thyroid cancer “epidemic” in South Korea: evidence from a nationwide study

Park

Cho

et al. 2016

BMJ

194

173

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“…Patients with incidental thyroid cancer tend to be older and have higher TNM stage disease and are more likely to be male compared with patients with nonincidental thyroid cancer. In addition, there does not appear to be a significant difference in the size, pathology, or behavior of the tumor at presentation between these two groups [16]. The results of these studies suggest that incidental thyroid cancer detected by PET-CT should be treated in the same manner as nonincidental thyroid cancer.…”

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confidence: 76%

Discovering Incidental Thyroid Disease by Imaging Studies

Lin

2015

Journal of Medical Ultrasound

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“…A brief review shows that urban areas have higher IRs and may, in part, contribute to the higher rates overall, where access to medical care is more readily available. This may lead to more thyroid cancers identified incidentally which, according to various studies, may represent approximately 15% to 24% of thyroid cancers (42).…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence in Appalachia, 2004–2011

Wilson

Ryerson

Singh

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Limited literature is available about cancer in the Appalachian Region. This is the only known analysis of all cancers for Appalachia and non-Appalachia covering 100% of the US population. Appalachian cancer incidence and trends were evaluated by state, sex, and race and compared with those found in non-Appalachian regions.Methods: US counties were identified as Appalachian or nonAppalachian. Age-adjusted cancer incidence rates, standard errors, and confidence intervals were calculated using the most recent data from the United States Cancer Statistics for 2004 to 2011.Results: Generally, Appalachia carries a higher cancer burden compared with non-Appalachia, particularly for tobacco-related cancers. For all cancer sites combined, Appalachia has higher rates regardless of sex, race, or region. The Appalachia and non-Appalachia cancer incidence gap has narrowed, with the exception of

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Characteristics of Incidentally Discovered Thyroid Cancer

Cited by 30 publications

References 28 publications

Association between screening and the thyroid cancer “epidemic” in South Korea: evidence from a nationwide study

Association between screening and the thyroid cancer “epidemic” in South Korea: evidence from a nationwide study

Discovering Incidental Thyroid Disease by Imaging Studies

Cancer Incidence in Appalachia, 2004–2011

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