Characteristics of individual thigh muscles including cross-sectional area and adipose tissue content measured by magnetic resonance imaging in knee osteoarthritis: a cross-sectional study

Yamauchi, Koun; Kato, Chisato; Kato, Takayuki

doi:10.1007/s00296-019-04247-2

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…In addition, to obtain true proximal femur aBMD, we used QCT, which has been demonstrated to have good consistency with DXA. Muscle CSA or muscle thickness, as a simple and practical muscle volume estimation method, has been widely used as an indirect indicator of muscle strength (20,21). As for the selection of muscle level, the CSA around the muscle abdomen decreases to the greatest extent due to disuse, while the CSA around the muscle end does not significantly change (22,23).…”

Section: Discussionmentioning

confidence: 99%

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Wang

Zhang

et al. 2022

Front. Endocrinol.

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PurposeTo investigate the relationship of muscle atrophy and fat infiltration around the hip joint with areal bone mineral density (aBMD) in each subregion of the proximal femur.Materials and methodsIn total, 144 participants (66 women and 78 men) were examined by quantitative computed tomography (QCT), and areal bone mineral density (aBMD) of the femoral neck (FN), trochanter (TR), and intertrochanter (IT) of the proximal femur were obtained. The cross-sectional area (CSA) and proton density fat fraction (PDFF) of the gluteus maximus (G.MaxM), gluteus medius (G.MedM), gluteus minimus (G.MinM), and iliopsoas (IliopM) were obtained via magnetic resonance imaging (MRI) using the mDIXON-Quant sequence. A multivariate generalized linear model was used to evaluate the correlation of the CSA and PDFF of muscles with aBMD in all subregions of the proximal femur.ResultsThe FN integral (Int) aBMD was significantly associated with the G.MaxM CSA (men: P = 0.002; women: P = 0.008) and PDFF (men: P < 0.001; women: P = 0.047). Some muscle indexes were related to the FN aBMD in males or females, including the CSA of G.MedM, G.MinM, and IliopM as well as the PDFF of IliopM and G.MinM. Associations of hip muscle parameters with the TR Int aBMD in both males and females were observed, including G.MaxM CSA (men: P < 0.001; women: P = 0.028) and G.MaxM PDFF (men: P = 0.031; women: P = 0.038). Other muscle indexes, including G.MedM and IliopM, were related to the TR aBMD, mainly affecting the aBMD of TR cortical (Cort) and TR Int. The IT Int aBMD and IT Cort aBMD showed significant correlation with the muscle indexes of G. MaxM, IliopM, and G.MedM, including the PDFF and CSA in males and females. Further, more indicators of the G.MedM and IliopM correlated with the TR and IT aBMD compared to the FN aBMD.ConclusionsThe CSA of gluteus muscles and iliopsoas had a positive association with the aBMD in the proximal femur, and the PDFF of gluteus muscles and iliopsoas had a negative correlation with the aBMD in the proximal femur. In addition, there was an interaction of the proximal femur aBMD with the muscle size and fatty infiltration of hip muscles.

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Section: Discussionmentioning

confidence: 99%

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Wang

Zhang

et al. 2022

Front. Endocrinol.

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“…2). 17 Lean muscle CSA was calculated as the muscle CSA minus the IMAT area, and the percentage of IMAT was calculated as the ratio of the IMAT area to the muscle CSA.…”

Section: Methodsmentioning

confidence: 99%

“…Clinical studies have shown that subjects with patellofemoral pain syndrome have low VM:VL muscle activity ratios during closed kinetic chain exercises (such as sit‐to‐stand transitions) 15,16 . Furthermore, a decrease in the VM:QM CSA ratio was most strongly associated with radiographic medial knee osteoarthritis severity 17 . Moreover, the ratio of a muscle to the other muscles has been generally used as a normalization method to reduce the influence of between‐subject variation, including SAT, sex, age, and physical differences 15–17 .…”

mentioning

confidence: 99%

“…15,16 Furthermore, a decrease in the VM: QM CSA ratio was most strongly associated with radiographic medial knee osteoarthritis severity. 17 Moreover, the ratio of a muscle to the other muscles has been generally used as a normalization method to reduce the influence of between-subject variation, including SAT, sex, age, and physical differences. [15][16][17] However, it is unknown which individual QM characteristics can independently predict the VM, VL, and RF muscle activity ratios during knee extension MVIC and sit-to-stand transitions.…”

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confidence: 99%

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The Relationship Between Quadriceps Femoris Muscle Function and MRI‐Derived Water Diffusion and Adipose Tissue Measurements in Young Healthy Males

Yamauchi¹,

Someya²,

Kato³

et al. 2022

Magnetic Resonance Imaging

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Background Water diffusion and adipose tissue in a muscle can be evaluated by MRI. However, determining which quadriceps femoris muscle (QM) characteristics independently predict peak knee extension torque during maximum voluntary isometric contractions (MVICs), individual muscle activity during MVICs and sit‐to‐stand transitions is unknown. Purpose To determine which QM characteristics predict knee extension muscle strength and individual muscle activity. Study Type Prospective, cross‐sectional. Subjects A total of 20 healthy males (aged 22–40 years) with a physical activity level <1 hour/week. Field Strength/Sequence 1.5‐T, diffusion‐weighted fast spin–echo echo‐planar imaging and T1‐weighted fast spin–echo sequences. Assessment The vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF), and vastus intermedius were segmented in a single axial diffusion‐weighted image and T1‐weighted image at the right mid‐thigh region. λ1–3 and fractional anisotropy (FA), and the percentage of intramuscular adipose tissue (IMAT) were measured. The knee extension peak force during MVICs was measured by a dynamometer, and the torque was calculated at the peak force × length. The ratios of the individual muscle activity to the total muscle (VM, VL, and RF) during MVICs and sit‐to‐stand transitions were assessed using surface electromyography. Statistical Tests Regression analysis was conducted to identify the predictors of peak knee extension torque and of individual muscle activity ratios. A P value < 0.05 was considered statistically significant. Results The RF λ1 significantly predicted the peak knee extension torque (β = −0.51). The IMAT percentage of the VM significantly predicted the VM muscle activity ratio during the MVIC and sit‐to‐stand transition (β = −0.82 and β = −0.61, respectively), whereas the ratio of the VM λ1 to the whole QM λ1 significantly predicted the VM muscle activity ratio during the sit‐to‐stand transitions (β = 0.35 and β = 0.46, respectively). Data Conclusion The RF λ1 may allow to estimate peak knee extension muscle torque, and the VM IMAT and λ1 may predict muscle activity in youth. Evidence Level 3. Technical Efficacy Stage 3.

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“…Regarding the association between knee muscle CSA and KOA, longitudinal studies have shown that CSA changes occur more rapidly in thigh muscles than changes in muscle strength in adult patients. 62,63 Yamauchi et al 64 used MRI and found that intermediate and advanced KOA patients had greater CSA in the vastus medialis, vastus lateralis, and vastus intermedius compared to early KOA patients. Vastus intermedius CSA was also associated with the Kellgren-Lawrence level.…”

Section: Muscle Cross-sectional Areamentioning

confidence: 99%

How Do Muscle Function and Quality Affect the Progression of KOA? A Narrative Review

Chen,

Zhou,

Gong

et al. 2024

Orthopaedic Surgery

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Knee osteoarthritis (KOA) is widely recognized as a chronic joint disease characterized by degeneration of knee cartilage and subsequent bone hyperplasia. However, it is important to acknowledge the significant role of muscles in the development and progression of KOA. Muscle function (MF) and muscle quality (MQ) are key factors in understanding the involvement of muscles in KOA. Quantitative indices such as muscle mass, muscle strength, muscle cross‐sectional area, muscle thickness, and muscle fatigue are crucial in assessing MF and MQ. Despite the growing interest in KOA, there is a scarcity of studies investigating the relationship between muscles and this condition. This review aims to examine the commonly used indices and measurement methods for assessing MF and MQ in clinical settings, while also exploring the association between muscles and KOA. Furthermore, this article highlights the importance of restoring MF and MQ to enhance symptom management and improve the quality of life for patients with KOA.

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Characteristics of individual thigh muscles including cross-sectional area and adipose tissue content measured by magnetic resonance imaging in knee osteoarthritis: a cross-sectional study

Cited by 8 publications

References 28 publications

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

The Relationship Between Quadriceps Femoris Muscle Function and MRI‐Derived Water Diffusion and Adipose Tissue Measurements in Young Healthy Males

How Do Muscle Function and Quality Affect the Progression of KOA? A Narrative Review

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