Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?

Hanes, Philip J.; Krishna, Ranjitha

doi:10.1007/s13167-010-0016-3

Cited by 40 publications

(47 citation statements)

References 138 publications

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“…[9] One study evaluated flora differences within patients with Type 2 Diabetes and those without Type 2 Diabetes to indicate the differences in structures, but unsuccessfully tracked variance in mechanisms. [10] One recent study targeted certain communities with Periodontitis to explore the underlying mechanism and background of this organism. The results show that the following Periodontitis-associated taxa are prevalent in most cases today.…”

Section: Periodontitismentioning

confidence: 99%

“…There is an increase in apoptosis of both fibroblasts and osteoclasts with the infection of P. gingivalis with the hyperglycemic background. [10] The unknown pairing of both diseases The exact underlying mechanisms that connect Type 2 Diabetes and Periodontitis are not yet known. However, it has been determined that these mechanisms do involve immune functioning, cytokine biology, and neutrophil activity.…”

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

“…GCF consists of "...connective tissue degradation, enzymes from host and bacterial cells, cytokines, and other inflammatory mediators…". [10] Saliva is used in a broad range of periodontal studies due to less cost Section: Dentistry involved, minimal invasiveness, and a promising number of biomarkers to test. [21] A recent study used GCF to test the levels of the glycoprotein YKL-40 in groups of individuals characterized with having periodontitis and some characterized with having diabetes.…”

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

“…[22] Biomarkers to tag the prevalence of both diseases Some of these inflammatory mediators give insight into the progression of both Periodontitis and Type 2 Diabetes. [10] A recently discovered biomarker, Orosomucoid, tests the progression of periodontitis in morbidly obese patients. The relationship between obesity and periodontitis was tested in a cross-sectional study focusing on the systemic inflammatory markers.…”

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

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Periodontitis in Patients with Type 2 Diabetes Mellitus

Agarwal¹,

Gangaram²,

Saleem³

2018

AIMDR

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Periodontitis is a chronic, inflammatory disease that is characterized by swollen gums, degradation of jaw structure, and potentially tooth loss. Like Periodontitis, Type 2 Diabetes Mellitus is also highly prevalent and largely multifactorial. Type 2 Diabetes is a condition in which higher than normal blood glucose levels cannot be properly maintained as the body's normal mechanism of maintaining proper blood glucose levels, the release of insulin from pancreatic islet β-cells, becomes ineffective. The purpose of this literature review is to explore the relationship between the incidences of Periodontitis and Type 2 Diabetes. The risk that Type 2 Diabetes poses for the incidence of Periodontitis is analyzed. Patients afflicted with Type 2 Diabetes were found to be approximately three times as likely to eventually suffer from Periodontitis, as well. There is also emerging evidence supporting the correlation between the degree of hyperglycemia and severity of Periodontitis. Potential underlying mechanisms linking the two conditions at the cellular level have been discussed. Immune functioning and cytokine biology are among discussed mechanisms. Recent discoveries have also suggested that Periodontitis may also negatively impact glycemic control. As a result, not only should healthcare providers emphasize oral health as part of Type 2 Diabetes management, but healthy eating and physical activity should be among recommendations that make up Periodontal management.

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Section: Periodontitismentioning

confidence: 99%

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

See 2 more Smart Citations

Periodontitis in Patients with Type 2 Diabetes Mellitus

Agarwal¹,

Gangaram²,

Saleem³

2018

AIMDR

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“…Local production of cytokines in the periodontal tissue affects glycemic control through systemic exposure and impairing intracellular insulin signaling thus potentially contributing to insulin resistance [23]. Hyperglycemic state may thus be enhanced in chronic periodontitis patients and periodontal therapy can therefore result in reduced HbA1c [24].…”

Section: Effect Of Oral Azithromycin and Metronidazole On Dental Paramentioning

confidence: 99%

Effect of Oral Azithromycin and Metronidazole as an Adjunct to Scaling and Root Planing on Glycemic Control in Type Ii Diabetic Patients With Chronic Periodontitis

Dhivya

Yogarajan²,

Shanmugarajan³

2017

Asian J Pharm Clin Res

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Objective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixth complication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, the present study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the level of serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical and biochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Package for Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than in patients who received metronidazole and scaling and root planning alone. Conclusion:Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus. Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However, due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.

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Parkinson's disease is positively associated with periodontal inflammation

Yilmaz

Yay

Balcı

et al. 2023

Journal of Periodontology

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BackgroundParkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden.MethodsWe recruited 60 patients with Stage III, Grade B periodontitis (P) with and without PA (n = 20 for each). We also included systemically and periodontally healthy individuals as controls (n = 20). Clinical periodontal parameters were recorded. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the inflammatory and neurodegenerative targets (YKL‐40, fractalkine, S100B, alpha‐synuclein, tau, vascular cell adhesion protein‐1 (VCAM‐1), brain‐derived neurotrophic factor (BDNF), neurofilament light chain (NfL).ResultsParkinson's patients in this study had mild to moderate motor dysfunctions, which did not prevent them from performing optimal oral hygiene control. Periodontal parameters and GCF volume were significantly higher in the P and P+PA groups than in the control group. PA was associated with significantly increased bleeding on probing (BOP) compared to P‐alone (p < 0.05), while other clinical parameters were similar between P and P+PA groups. In saliva and serum, YKL‐40 levels were higher in the P+PA group than in P and C groups (p < 0.001). GCF NfL levels from shallow sites were significantly higher in the P+PA group compared to the C group (p = 0.0462). GCF S100B levels from deep sites were higher in the P+PA group than in healthy individuals (p = 0.0194).ConclusionThe data suggested that PA is highly associated with increased periodontal inflammatory burden—bleeding upon probing and inflammatory markers—in parallel with PA‐related neuroinflammation.

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Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible?

Cited by 40 publications

References 138 publications

Periodontitis in Patients with Type 2 Diabetes Mellitus

Periodontitis in Patients with Type 2 Diabetes Mellitus

Effect of Oral Azithromycin and Metronidazole as an Adjunct to Scaling and Root Planing on Glycemic Control in Type Ii Diabetic Patients With Chronic Periodontitis

Parkinson's disease is positively associated with periodontal inflammation

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