Characteristics of inflammatory eye disease associated with hidradenitis suppurativa

Saygın, Didem; Syed, Abrahim; Lowder, Careen Y.; Srivastava, Sunil K.; Maya, Juan J; Hajj‐Ali, Rula A.

doi:10.5152/eurjrheum.2018.17163

Cited by 23 publications

(38 citation statements)

References 19 publications

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“…In 3 cases concomitant Adamantiades-Behçet disease could account for anterior uveitis or episcleritis; 2 patients suffered from conjunctivitis and 1 patient had bilateral ulcerative keratitis (Mooren's ulcer) [55,56,62]. In a study by Saygın et al [67], the most common types of inflammatory eye involvement were uveitis (65%) followed by scleritis (30%) and peripheral ulcerative keratitis.…”

Section: Discussionmentioning

confidence: 99%

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

et al. 2020

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Background: There is growing evidence that (certain) hidradenitis suppurativa (HS) comorbidities comprise syndromes including HS as a key cutaneous manifestation. These apparently autoinflammatory syndromes and their diagnostic delay might have detrimental effects on affected patients. Methods: A systematic review was performed on the databases MEDLINE, EMBASE, and CENTRAL utilizing a standardized extraction form according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Sixty-four eligible articles on syndromic HS were retrieved. The identified syndromes included already described ones (pyoderma gangrenosum-acne-suppurative hidradenitis, pyogenic arthritis-pyoderma gangrenosum-acne-suppurative hidradenitis, psoriatic arthritis-pyoderma gangrenosum-acne-suppurative hidradenitis, pyoderma gangrenosum-acne vulgaris-hidradenitis suppurativa-ankylosing spondylitis, synovitis-acne-pustulosis-hyperostosis-osteitis) and further novel symptom constellations. Cutaneous signs, including HS lesions, usually precede signs from other organs. The cutaneous signs of a considerable proportion of patients appear refractory to conventional treatment, and monotherapy with biologics does not suffice to sustain remission. Conclusion: The results are subsequently discussed with focus on the pathophysiology and treatment of the detected syndromes. The dermatologist’s role in the precise diagnosis and early treatment administration of HS is pivotal. The purpose of the treatment should be the effective prevention or delay of the autoinflammatory march and its irreversible consequences.

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Section: Discussionmentioning

confidence: 99%

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

et al. 2020

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“…The acute component is inflammatory in nature and is related to the inflamed cysts and nodules that develop. 9 , 10 , 12 , 13 Patients describe it as being similar to neuropathic pain, citing sensations of stabbing, burning, and shooting. According to Patel et al, 12 chronic pain is associated with more advanced inflammatory HS, and is described by patients as aching, throbbing, and gnawing.…”

Section: Introductionmentioning

confidence: 99%

Erector spinae block for postoperative analgesia following axillary hidradenitis suppurativa resection: a case report

Haan

Hernandez

Sen

2018

LRA

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the terminal hair follicle of the apocrine gland-bearing skin, presenting with inflamed nodules, abscesses, and sinus tracts. Autoimmune, genetic, and infectious factors have been implicated in its pathogenesis. HS can be managed medically using topical and systemic antibiotics and with tumor necrosis factor antibody therapy in severe cases. Surgical treatment can range from local excision, deroofing or excision of sinus tracts, or wide radical excision of severe lesions. Lesions can be severely painful on their own or following surgical resection. Patients may require opioid therapy due to pain from the lesions themselves or following painful surgical resection. Erector spinae block (ESB) is a recently developed plane block used for the management of pain located in the chest wall or the abdominal wall. Ultrasound guidance is used to guide placement of the needle tip between the transverse process at the desired dermatomal level and the erector spinae muscle group. Traditional descriptions of the ESB have been at the level of the fifth transverse process to treat chest wall pain; in this case report, we describe a novel use of ESB at the level of the second transverse process to treat axillary pain after surgical debridement of axillary HS.

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“…It is characterized by cystic lesions that develop in the deep dermis, which often rupture, producing suppurative material [2, 3]. While there are classic areas of distribution for HS, it can affect many parts of the body, including the eye [4]. Cases with ocular involvement are rare.…”

mentioning

confidence: 99%

“…Cases with ocular involvement are rare. In a study looking at inflammatory eye disease (IED) in patients with HS, only 1% of IED could be attributed to HS alone, while 4% had another comorbid autoimmune disorder that could have produced ocular findings [4]. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.…”

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confidence: 99%

“…While the primary inciting events for HS occur in regions of high apocrine gland density, the subsequent systemic inflammation can have far-reaching effects, with multiple cases of HS associated with IED [4]. HS-associated IED includes bilateral interstitial keratitis [18], uveitis [4], Mooren-type ulcerations [19, 20], scleritis [4], glands of Moll involvement with mucopurulent discharge [21] (which are apocrine glands [22]), lacrimal sacs (including fistula formation) [23], and peripheral ulcerative keratitis (PUK) [4]. While there is no published information on patients with HS who have undergone LASIK, studies on LASIK in patients with well-controlled autoimmune or immune-mediated inflammatory diseases have shown that LASIK can be safely performed [24].…”

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confidence: 99%

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Should Patients with Hidradenitis Suppurativa Undergo LASIK?

et al. 2019

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Hidradenitis suppurativa (HS) is a relatively common chronic inflammatory disease with immune dysregulation. While eye manifestations of HS are rare, a dilemma arises when these patients seek treatment for refractive errors. Although excimer laser surgery can be safely performed in patients with autoimmune and immune-mediated inflammatory disease, there are caveats. Aside from the routine laser-assisted in situ keratomileusis (LASIK) screening tests, in some instances, we recommend additional screening tests in patients with HS, such as dry eye tests, consultation with specialists regarding HS diagnosis and treatment, careful assessment of the eyelids and periorbital structures, and thorough history of past and current lesions and treatments. After these patients undergo LASIK, careful, frequent, and long-term follow-up is necessary. Any adverse event or complication should be managed immediately. Funding Research to Prevent Blindness funded the study. Hoopes Vision funded the Rapid Service Fees.

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Characteristics of inflammatory eye disease associated with hidradenitis suppurativa

Cited by 23 publications

References 19 publications

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

Phenotypes and Pathophysiology of Syndromic Hidradenitis Suppurativa: Different Faces of the Same Disease? A Systematic Review

Erector spinae block for postoperative analgesia following axillary hidradenitis suppurativa resection: a case report

Should Patients with Hidradenitis Suppurativa Undergo LASIK?

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