Characteristics of ivermectin toxicity in patients taking veterinary and human formulations for the prevention and treatment of COVID-19

Hoang, Ruby; Temple, Courtney; Correia, Matthew S.; Clemons, Joseph; Hendrickson, Robert G.

doi:10.1080/15563650.2022.2134788

Cited by 12 publications

(7 citation statements)

References 9 publications

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“…It is important to notice that this non-rational drug use carries risks. Cardiotoxicity and other toxic effects were reported during the pandemic in patients that consumed ivermectin and antimalarial in acute high doses and chronically 33 , 34 .…”

Section: Discussionmentioning

confidence: 99%

Post-Covid condition and clinic characteristics associated with SARS-CoV-2 infection: a 2-year follow-up to Brazilian cases

da Silva,

de Araújo,

dos Santos

et al. 2023

Sci Rep

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Until January 2023, Brazil recorded 37 million COVID-19 cases despite the decrease in mortality due to mass vaccination efforts against COVID-19. The infection continues to challenge researchers and health professionals with the persistent symptoms and onset manifestations after the acute phase of the disease, namely Post-Covid Condition (PCC). Being one of the countries with the highest infection rate, Brazil must prepare for a growing number of patients with chronic health consequences of COVID-19. Longitudinal studies that follow patients over extended periods are crucial in understanding the long-term impacts of COVID-19, including potential health consequences and the effects on quality of life. We describe the clinical profile of a cohort of COVID-19 patients infected during the first year of the pandemic in Brazil and a follow-up after two years to investigate the health impacts of SARS-CoV-2 infection. The first wave of SARS-CoV-2 infection in Brazil featured extensive drug misuse, notably the ineffective COVID kit comprised of ivermectin, antimalarials and azithromycin, and elevated in-hospital mortality. In the second phase of the study, Post-Covid Condition was reported by symptomatic COVID-19 subjects across different severity levels two years after infection. Long haulers are more likely to be women, previously hospitalized, and reported a range of symptoms from muscle pain to cognitive deficit. Our longitudinal study is essential to inform public health authorities to develop strategies and policies to control the spread of the virus and mitigate its impacts on society.

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Section: Discussionmentioning

confidence: 99%

Post-Covid condition and clinic characteristics associated with SARS-CoV-2 infection: a 2-year follow-up to Brazilian cases

da Silva,

de Araújo,

dos Santos

et al. 2023

Sci Rep

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“…During the coronavirus disease 2019 (COVID-19) pandemic, patients taking veterinary ivermectin for self-treatment had increased rates of neurotoxicity, most likely due to the higher dosing of veterinary formulations. 9 Other veterinary medicines, such as barbiturates, xylazine, and acepromazine, have been reported in lethal human overdoses. 10 In the United States, veterinarians can prescribe schedule II to V drugs.…”

Section: Discussionmentioning

confidence: 99%

When Veterinary Drugs Reach Human Hospitals: A Problem-Based Learning Discussion

et al. 2023

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The delivery of drugs from the manufacturer to the hospital is a complex process. Despite numerous safeguards, lapses may occur, creating the potential for patient harm. Recently, an urban tertiary care medical center received a shipment of isoflurane bottles labeled for veterinary use. This error was not identified until the veterinary isoflurane reached the operating room automated medication dispensing system. No patients received the anesthetic. This report describes how such an error occurred, explains the differences between veterinary and human medications, and emphasizes the importance of vigilance in the drug supply chain to prevent patient harm.

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“…Most of the patients were male, elderly (age > 60 years) and had gastrointestinal distress or neurological symptoms (dizziness, ataxia, seizures). Those using veterinary formulations had more manifestations of toxicity [24,25].…”

Section: Recreational Drugs Cannabis and Cannabis Containing Productsmentioning

confidence: 99%

Metabolic management of accidental intoxication

Khatib,

Dixit,

Telang

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Unintentional intoxication comprises a major chunk of all intoxications. Most patients are in the pediatric age group with another set of patients being the elderly. Substances found to cause accidental intoxication vary from country to country and even within different regions of a country. Frequent reviews of current literature are needed to be abreast of trends. Recent findings Prescription drugs and household chemicals are major culprits when it comes to accidental intoxication. Acetaminophen, digoxin and metformin are some of the prominent prescription drugs frequently associated with unintentional intoxications. Increasingly alcohol based hand sanitizers are becoming an important etiology of these events, following their increased usage during the COVID-19 pandemic. Pattern recognition to identify class of intoxicant and supportive care including prevention of further absorption and increased excretion are cornerstones of therapy. Antidote when available should be used promptly. Summary Knowledge about current epidemiology of accidental intoxications, toxidrome pattern recognition and appropriate antidote usage beside adequate and timely supportive care help in successful management of the unfortunate victim of accidental intoxication.

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Characteristics of ivermectin toxicity in patients taking veterinary and human formulations for the prevention and treatment of COVID-19

Cited by 12 publications

References 9 publications

Post-Covid condition and clinic characteristics associated with SARS-CoV-2 infection: a 2-year follow-up to Brazilian cases

Post-Covid condition and clinic characteristics associated with SARS-CoV-2 infection: a 2-year follow-up to Brazilian cases

When Veterinary Drugs Reach Human Hospitals: A Problem-Based Learning Discussion

Metabolic management of accidental intoxication

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