Characteristics of keratinocyte carcinomas in Hispanics compared to non‐Hispanic whites: A retrospective 5‐year study

Cheng, Judy; Rajanala, Susruthi; Widjajahakim, Rafael; Maymone, Mayra B.C.; Vashi, Neelam A.

doi:10.1111/phpp.12504

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…4 Studies outside the Medicare population have often noted a predominance of BCC in younger patients but with widely varying point estimates of the relative burden of BCC to cSCC. [3][4][5] Finally, data on KCs in patients with skin of color in the United States are limited, mostly to regional 6,7 or single-center [8][9][10][11][12][13][14][15] data. Importantly, none of these prior analyses have attempted to simultaneously analyze and adjust their estimates for age, sex, and race; and given that they derive from geographically restricted populations, the geographic variation in the BCC:cSCC ratio is poorly understood.…”

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confidence: 99%

Association of Age, Sex, Race, and Geographic Region With Variation of the Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States

et al. 2020

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IMPORTANCE Defining which populations are affected by basal cell carcinoma (BCC) vs cutaneous squamous cell carcinoma (cSCC) may inform targeted public health strategies. Incidence of BCC and cSCC is not reported to national cancer registries, but claims data for the treatment of BCC and cSCC provide insights into the epidemiology of keratinocyte carcinoma.OBJECTIVE To define differences in the ratio of BCC to cSCC in adults (age, Ն18 years) in a large database of patients with commercial insurance and Medicare Advantage coverage. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional analysis used deidentified data derived from the Optum Clinformatics Data Mart to perform a retrospective evaluation of a large commercially insured cohort based on treatment claims from January 1, 2012, to December 31, 2016. Patients with a diagnosed and treated BCC or cSCC as determined by codes from the

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confidence: 99%

Association of Age, Sex, Race, and Geographic Region With Variation of the Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States

et al. 2020

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“…When comparing histology across racio-ethnic groups, there was a higher prevalence of nodular histology in Hispanics compared to the NHW, though this did not meet statistical significance. While previous studies suggest that Hispanics may have less aggressive histological features of BCC, 10,19,36 this is contradicted by the fact that Hispanics with BCC have worse clinical outcome. 10,11,31,36 Additionally, we also found 58% of BCC in Hispanics were pigmented as opposed to less than 16% in NHW.…”

Section: Discussionmentioning

confidence: 88%

“…While previous studies suggest that Hispanics may have less aggressive histological features of BCC, 10,19,36 this is contradicted by the fact that Hispanics with BCC have worse clinical outcome. 10,11,31,36 Additionally, we also found 58% of BCC in Hispanics were pigmented as opposed to less than 16% in NHW. Clinically, pigmented basal cell carcinomas (PBCC) are more common in POC, 37,38 with studies estimating the prevalence of PBCC to be as high as 50%-65% among Hispanics 6,25,39,40 compared to only 5%-11% among NHW.…”

Section: Discussionmentioning

confidence: 88%

Clinicopathologic comparison of basal cell carcinoma among a diverse patient population in Los Angeles County

Choi,

Oberg,

Hijazi

et al. 2024

Skin Health and Disease

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IntroductionBasal cell carcinoma (BCC) is the most common malignancy in the United States. The majority of cases are identified in Non‐Hispanic Whites (NHW) and are far less demonstrated in patients of colour (POC). However, the Hispanic population represents a large and growing proportion of the US population, and skin cancer diagnoses in Hispanics are rising. Thus, the goal of this study is to examine clinicopathologic differences between BCC in Hispanics versus NHW.MethodsA retrospective chart review of Hispanic and NHW patients with BCC at Los Angeles County + USC Medical Center from January 2018 to March 2020 was performed. In total, 101 BCC samples from the first 100 patients identified of Hispanic ancestry, as well as 50 BCC samples identified from the first 50 patients identifying as NHW, were included for analysis. Patient characteristics (age, sex, medical history, and ethnicity), as well as tumour characteristics (location, subtype, tumour depth, and perineural invasion), were collected. We used between subjects t‐tests for continuous variables, and chi‐square tests for categorical variables.ResultsIn total, 151 specimens were collected amongst 122 subjects (79 Hispanics and 43 NHW patients). Among NHW, the majority of patients (74.4%) were men, but among the Hispanic population, the majority (68.4%) were female (p < 0.001). Prior history of other skin cancer was more common among NHW (67.4%) than Hispanics (31.6%) (p=<0.001). The Hispanic population had a significantly higher proportion of head and neck tumours (p = 0.0004) but a lower proportion of extremity tumours (p = 0.001) compared to NHW. Pigmented BCC was significantly more common among Hispanic patients (p < 0.01). Finally, within the Hispanic group, there was a significant association between sex and histology (p = 0.004), with Hispanic men demonstrating more aggressive mix histology compared to Hispanic women.DiscussionOur study supports the notion that BCC disparities occur among POC compared to NHW. This includes variations in epidemiologic factors such as sex and past medical history, primary tumour location, and pathologic characteristics. Further research should be conducted to identify additional differences in skin cancer presentation in POC to reduce the gaps in skin cancer knowledge and care.

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Skin Cancer in People of Color: A Systematic Review

et al. 2021

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Characteristics of keratinocyte carcinomas in Hispanics compared to non‐Hispanic whites: A retrospective 5‐year study

Cited by 3 publications

References 18 publications

Association of Age, Sex, Race, and Geographic Region With Variation of the Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States

Association of Age, Sex, Race, and Geographic Region With Variation of the Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States

Clinicopathologic comparison of basal cell carcinoma among a diverse patient population in Los Angeles County

Skin Cancer in People of Color: A Systematic Review

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