Characteristics of multiple sclerosis and demyelinating disease in an Asian American population

Fan, Jessica H; Alexander, Jessa; Poole, Shane; Wijangco, Jaeleene; Henson, Lily J; Dobson, Ruth; Guo, Chu-Yueh; Bove, Riley

doi:10.1177/13524585231188486

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…Specifically, a number of previous studies have suggested that MS has a more aggressive course in people from Black and Hispanic ethnic backgrounds, with earlier onset, more rapid disability progression, greater cognitive and physical impairment, and poorer response to disease-modifying therapies 10–21 . Other studies have shown an earlier age at onset in Southeast Asian 22 and South Asian persons 23,24 .…”

Section: Introductionmentioning

confidence: 80%

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The relationship between ethnicity and Multiple Sclerosis characteristics in the United Kingdom: a UK MS Register study

Jacobs,

Schalk,

Tregaskis-Daniels

et al. 2024

Preprint

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Previous studies have suggested differences in Multiple Sclerosis severity between individuals from different ethnic backgrounds. However, these measures of severity have been focussed on markers of physical disability derived from clinical records. We sought to determine the association between self-reported ethnicity and Multiple Sclerosis severity across a range of domains in a prospective cohort based in the United Kingdom. Data were obtained from the United Kingdom Multiple Sclerosis Register, a longitudinal cohort study of >20,000 persons with Multiple Sclerosis. We examined the association between self-reported ethnic background and age at onset, site of onset, and a variety of participant-reported severity measures: the Expanded Disability Status Scale, the Multiple Sclerosis Impact Scale, the Multiple Sclerosis Walking Scale, the Fatigue Severity Scale, and the EuroQol-5D quality of life index. We used multivariable linear regression models adjusted for age, sex, and Multiple Sclerosis subtype (Primary Progressive vs other). We explored the association between ethnicity and impact of Multiple Sclerosis using Cox proportional hazards models to assess the rate of disability progression. Data were available for 14,264 people with Multiple Sclerosis, including 380 participants from self-reported Black (n=151) or South Asian (n=229) ethnic backgrounds. Age at Multiple Sclerosis onset and diagnosis was lower in the participants of South Asian (median onset 31.0) and Black (median onset 33.0) ethnicity compared with White ethnicity (median onset 35.0, n=13,884). We found no statistically-significant evidence for an association between ethnic background on baseline Multiple Sclerosis severity scores in any of the scores tested across a range of sensitivity analyses. In longitudinal analysis, we did not find evidence for an impact of ethnicity on five-year risk of disability progression. In this large, ethnically-diverse Multiple Sclerosis cohort with universal access to healthcare, we find no association between ethnic background per se and MS severity, whether in cross-sectional or longitudinal analyses. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings of heterogeneity between ethnic groups.

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Section: Introductionmentioning

confidence: 80%

“…Other studies have shown an earlier age at onset in Southeast Asian 22 and South Asian persons 23,24 .…”

Section: Introductionmentioning

confidence: 81%

The relationship between ethnicity and Multiple Sclerosis characteristics in the United Kingdom: a UK MS Register study

Jacobs,

Schalk,

Tregaskis-Daniels

et al. 2024

Preprint

Self Cite

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The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study

Jacobs,

Schalk,

Tregaskis-Daniels

et al. 2024

Mult Scler

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Background: Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity. Methods: Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression. Results: We analysed data from 17,314 people with MS, including participants from self-reported Black ( n = 157) or South Asian ( n = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses. Conclusion: We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.

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Characteristics of multiple sclerosis and demyelinating disease in an Asian American population

Cited by 2 publications

References 31 publications

The relationship between ethnicity and Multiple Sclerosis characteristics in the United Kingdom: a UK MS Register study

The relationship between ethnicity and Multiple Sclerosis characteristics in the United Kingdom: a UK MS Register study

The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study

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