Characteristics of neuropathic pain and its relationship with quality of life in 72 patients with spinal cord injury

Nagoshi, Narihito; Kaneko, Shinjiro; Fujiyoshi, Kanehiro; Takemitsu, Masakazu; Yagi, Mitsuru; Iizuka, Shingo; Miyake, Atsushi; Hasegawa, Atsushi; Machida, Masayoshi; Konomi, Tsunehiko; Asazuma, Takashi; Nakamura, Masaya

doi:10.1038/sc.2015.210

Cited by 47 publications

(26 citation statements)

References 25 publications

(38 reference statements)

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“…A previous study reported that individuals with an AIS grade of B experienced more intense NP than those with other grades (9). A relationship between completeness of injury and prevalence of pain was also reported previously (21).…”

Section: Pain Variables As Predictors Of Craig Handicap Assessment Resupporting

confidence: 66%

“…Pain takes a toll on an individual's activity levels and mental health status, reducing their quality of life (QoL). Chronic pain is associated with poorer psychological functioning and lower QoL (7)(8)(9)(10). Social integration is an important factor for health-related QoL after critical illness (11).…”

mentioning

confidence: 99%

“…Some studies have evaluated pain patterns, complaints, and the associations with QoL in individuals with SCI (7)(8)(9). However, to date, few studies have examined the association between chronic pain and social integration after SCI.…”

mentioning

confidence: 99%

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Pain correlates with social integration in individuals with traumatic spinal cord injury: A cross-sectional survey

Da-wu¹,

He²,

Li³

et al. 2019

J Rehabil Med

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After spinal cord injury, pain is a common and sometimes severe complication. Social integration has been linked to positive outcomes including better physical health. This study aimed at exploring the association between pain and social integration post-spinal cord injury. Our results showed that those with neuropathic pain presented more severe pain. The presence of pain negatively impacted social integration post injury. Pain interference was the best pain item to predict social integration in those who reported pain. Objective: To describe the relationship between pain and social integration following spinal cord injury using comprehensive evaluation of pain-related clinical characteristics and different aspects of social integration. Design: A cross-sectional study. Participants: A total of 318 participants with American Spinal Cord Injury Association Impairment Scale (AIS) Grades A, B, C or D and > 3 months post-injury. Methods: All participants completed the survey relating to demographics, pain characteristics, and the Craig Handicap Assessment Reporting Technique Social Integration scores. Results: Individuals who were younger, those 3-6 years after injury, and those with a grade of AIS grade A (odds ratio (OR) 8.32, 95% confidence interval (95% CI) 1.83-12.07) or B (OR 3.25, 95% CI 0.91-7.63) were more likely to report neuropathic pain. Significant inverse correlations were found between pain intensity and social integration (R =-0.597, p = 0.019). Brief Pain Inventory interference scores were negatively associated with 5 (friends, living situation, business, strangers and family) of 6 domains of Craig Handicap Assessment Reporting Technique social integration (p < 0.001). Pain type and only one domain (strangers) showed a significant negative relationship (B=-1.47, p = 0.02). Conclusion: Chronic pain after spinal cord injury is negatively associated with Craig Handicap Assessment Reporting Technique social integration. Brief Pain Inventory Pain interference, to a greater extent than pain type, best predicts social integration after spinal cord injury.

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Section: Pain Variables As Predictors Of Craig Handicap Assessment Resupporting

confidence: 66%

mentioning

confidence: 99%

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Pain correlates with social integration in individuals with traumatic spinal cord injury: A cross-sectional survey

Da-wu¹,

He²,

Li³

et al. 2019

J Rehabil Med

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“…Transport 155 (40) 64 (44) 93 (40) 126 (42) 158 (42) 61 (39) Fall 124 (32) 37 (25) 69 (30) 92 (31) 107 2853 (34) Other traumatic cause 48 (12) 16 (11) 33 1431 1045 1220 (13) Employment (full or part time), yes, n (%) 34 (15) 72 2454 1452 (34) Moderate 142 (37) 44 (30) 87 (38) 99 (33) 135 3651 (33) Much 185 (48) 40 (27) 110 (47) 115 (38) 184 4842 (27) Quality of life, NRS (0-10), mean (s. reported treatment for spasticity. Baclofen was the most frequently used medication for spasticity used by 40% (35% oral and 5% pump) of those with spasticity ( Figure 1).…”

Section: Spasticitymentioning

confidence: 99%

“…8,9 Chronic pain is associated with poorer psychological functioning and lower quality of life, 8,[10][11][12][13][14] but few studies have looked into the role of specific pain types on quality of life. 15,16 Spasticity is another common complication present in about 70% of all SCI after the first year. 17 Spasticity is a broad term that includes velocity-dependent increase in muscle tone, enhanced tendon reflexes, muscle spasms and clonus.…”

Section: Introductionmentioning

confidence: 99%

Pain, spasticity and quality of life in individuals with traumatic spinal cord injury in Denmark

et al. 2016

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Effects of multiple transcranial magnetic stimulation sessions on pain relief in patients with chronic neuropathic pain: A French cohort study in real‐world clinical practice

Thomas,

Fauchon,

Oriol

et al. 2024

European Journal of Pain

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BackgroundCurrent clinical trials indicate that repetitive transcranial magnetic stimulation (rTMS) is effective in reducing drug‐resistant neuropathic pain (NP). However, there is a lack of studies evaluating the long‐term feasibility and clinical efficacy of rTMS in large patient cohorts in real‐world conditions.MethodsIn this retrospective cohort study, we analysed 12 years of clinical data to assess the long‐term analgesic effects of 20 Hz rTMS over the primary motor cortex in patients with NP. Subgroup analyses were conducted to identify predictive factors and assess the potential role of epidural motor cortex stimulation (eMCS) as a sustained solution.ResultsIn total, 193 patients completed test period of 4 rTMS sessions and 42% of them reported a pain relief (PR) greater than 30%, with concurrent improvement in their most disabling symptom. Iterative rTMS sessions maintained analgesic effects over 10 years in certain patients identified as responders (≥10% PR) without adverse effects. Success probability was higher in patients with central NP compared to peripheral NP (OR = 2.03[1.04;4.00]), and among those with central post‐stroke pain, this probability was higher in ischemic versus hemorrhagic strokes (OR = 3.36[1.17;10.05]). PR obtained with iterative rTMS sessions was an excellent predictor of eMCS efficacy.ConclusionsWhile rTMS shows promise as a therapeutic option for some patients with drug‐resistant NP, it does not benefit all patients. Efficacy varies by NP aetiology, aiding patient selection. For responders, eMCS may offer a permanent solution. These findings support a tailored approach to rTMS in NP management, while recognizing both its potential and limitations across diverse patient profiles.Significance StatementMultiple rTMS sessions demonstrate long‐term efficacy and safety in treating drug‐resistant neuropathic pain. Extending session numbers for the test period can enhance responder identification, especially in patients with initial low pain relief. This identification refines patient selection for neurosurgery, reducing non‐responders. Central neuropathic pain shows higher success rates than peripheral. For post‐stroke central pain, patients with ischemic stroke are more likely to respond than those with hemorrhagic stroke. These results support integrating rTMS into clinical practice for managing neuropathic pain.

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Characteristics of neuropathic pain and its relationship with quality of life in 72 patients with spinal cord injury

Cited by 47 publications

References 25 publications

Pain correlates with social integration in individuals with traumatic spinal cord injury: A cross-sectional survey

Pain correlates with social integration in individuals with traumatic spinal cord injury: A cross-sectional survey

Pain, spasticity and quality of life in individuals with traumatic spinal cord injury in Denmark

Effects of multiple transcranial magnetic stimulation sessions on pain relief in patients with chronic neuropathic pain: A French cohort study in real‐world clinical practice

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