Characteristics of New Oxygen-Carrying Plasma and Its Application Prospects in the Treatment of Severe Acute Pancreatitis

Abstract

Oxygen-carrying plasma, a new type of colloid substitute, is composed of hydroxyethyl starch and acellular hemoglobin-based oxygen carriers. It can supplement colloidal osmotic pressure and rapidly improve the body's oxygen supply. The resuscitation effect of the new oxygen-carrying plasma in animal shock models is better than that of hydroxyethyl starch or hemoglobin-based oxygen carriers alone. It can reduce the histopathological damage and mortality associated with severe acute pancreatitis, and it is expected to become an interesting treatment method for severe acute pancreatitis. This article reviews the characteristics of the new oxygen-carrying plasma, its role in fluid resuscitation, and its application prospects in the treatment of severe acute pancreatitis.

Hetastarch-stabilized polypyrrole with hyperthermia-enhanced release and catalytic activity for synergistic antitumor therapy

“…Hetastarch (HES) is a semi-synthetic polysaccharide that has been extensively employed in the clinic as a plasma substitute due to its excellent immunocompatibility and low allergy rate. [33][34][35][36] It is interesting that HES has analogous structure and physicochemical characteristics with polyvinyl alcohol, such as abundance hydroxyl groups, good water solubility, and solvent stability. 37,38 Inspired by this, we innovatively developed a one-step synthesis approach for HESdoped Cu-based PPy (termed as HES@CuP) by using copper chloride as an oxidant and replacing traditional polyvinyl alcohol with HES as a stabilizer (Scheme 1).…”