Characteristics of Newly Diagnosed Type 2 Diabetes in Chinese Older Adults: A National Prospective Cohort Study

Lv, Fang; Cai, Xiaoling; Hu, Dayi; Pan, Changyu; Zhang, Danyi; Xu, Jie

doi:10.1155/2019/5631620

Cited by 11 publications

(11 citation statements)

References 26 publications

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“…It was similar to that (25.9%) in Shaanxi Province in western China [31]. However, it was much lower than the national-wide data (36.7% [25]-47.8% [2,12,32]). The reason accounting for the discrepancy might be those data either from a tertiary / secondary hospital [12] or from epidemiological study [32], which might under-estimate a real-world worse situation.…”

Section: Discussionsupporting

confidence: 78%

“…The reason accounting for the discrepancy might be those data either from a tertiary / secondary hospital [12] or from epidemiological study [32], which might under-estimate a real-world worse situation. Because the former one may represent patients with better medical resources [12], and the later one included a lot of new-diagnosed diabetes patients who had relatively low HbA 1C [32].…”

Section: Discussionmentioning

confidence: 99%

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Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics

An¹,

Wang

Cao

et al. 2020

Preprint

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Aim:To evaluate the atherosclerotic cardiovascular diseases (ASCVD) risk factors in type 2 diabetes (T2DM) patients from the primary diabetes clinics for further comprehensive intervention in China.Methods:A cross-sectional study was conducted in 5 primary diabetes chain hospitals in Beijing, Lanzhou, Harbin, Chengdu and Taiyuan in continuous patients with T2DM from March 2016 to December 2019. The data collected at the first visit were analyzed, and proportions of patients reached the targets (glycosylated hemoglobin (HbA1C) < 7%, blood pressure < 130 / 80mmHg, and low-density lipoprotein cholesterol (LDL-C) < 2.6mmol/l) were calculated. The differences among different hospitals, different treatment and numbers of aggregated ASCVD risk factors were compared.Results:A total of 20,431 participants, including 11,363 men (55.6%), with an average age of (59.4 ± 10.4) years were enrolled. Nearly 95% diabetes had one or more ASCVD risk factors other than hyperglycemia. The control rates of HbA1C, blood pressure, and LDL-C were 26.5%, 27.9%, and 42.6%, respectively. Only 4.1% patients achieved all 3 targets. Diabetes duration, family history and overweight/obesity were associated with the number of aggregated ASCVD risk factors. And the patients with short duration, no overweight/obesity, not smoking, less ASCVD risk factors and lived in Chengdu were associated with a higher control rates.Conclusions:In confront of poor control status, global management of ASCVD risk factors including weight loss and smoking stopping must be emphasized in the primary diabetes care settings.Highlights:The prevalence of ASCVD risk factors was high and control rates were low in the primary diabetes care hospitals in China.Overweight/obesity, smoking and resident area were associated with the aggregated ASCVD risk factors and worse control.Trial registration:Current ClinicalTrial.gov protocol ID NCT03707379. Date of Registration: October 16, 2018.https://clinicaltrials.gov

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics

An¹,

Wang

Cao

et al. 2020

Preprint

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“…[14] [15]. In a recent Chinese study involving 5770 elderly diabetic patients, it was found that the mean value of hemoglobin A1c at diagnosis was 7.9%, and after a year of follow-up, this figure decreased to 6.6% [14]. The Swedish national diabetes register also found a relatively low (6.6% -6.7%) level of hemoglobin…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus in Very Elderly Russian Patients with Coronary Artery Disease

Topolyanskaya¹,

Kolontai²,

Vakulenko³

et al. 2020

JBM

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Background: Conflicting data are available on prevalence and characteristics of diabetes mellitus in very elderly patients and centenarians; therefore, we evaluated features of this pathology in patients with coronary artery disease (CAD) over 75 years old. Material and Methods: 580 patients with CAD over 75 years old were enrolled in the study on the prevalence of diabetes mellitus. 190 patients with CAD and diabetes mellitus were included in the cross-sectional study of the diabetes mellitus characteristics in old age: 153 very elderly patients (mean age-85.7 ± 4.7 years)-in the main group, 37 patients < 70 years old-in the comparison group. Toassess the condition of patients, standard clinical and laboratory methods for coronary artery disease and diabetes mellitus were used. 24-hour plasma glucose profile and hemoglobin A1c (HbA1c) level were evaluated in all patients with diabetes mellitus. Results: Diabetes mellitus or impaired glucose tolerance was found in 22.2% of very elderly patients with CAD. Glucose levels in very elderly diabetic patients were lower at all time points than in patients < 70 years old. The largest differences were recorded for the blood glucose concentration at 6 a.m. (p = 0.00005). Glucosuria was registered in 29.7% of patients aged 51-69 years, while among elderly patients-in 11.1% (p = 0.004). The mean levels of HbA1c were 7.3% and 8.7%, respectively (p = 0.01). Correlation analysis revealed negative correlation between the age of patients and the glucose level (r = −0.4, p = 0.00002-for 6 AM glucose). The mean body mass index in very elderly patients was 30.8 ± 5.8 kg/m 2 , in patients < 70 years old-33.9 ± 6.5 kg/m 2 (p = 0.03). Significant differences between the groups of very elderly and younger patients were registered in terms of triglycerides (1.65 and 3.57 mmol/L, respectively, p < 0.00001), HDL-cholesterol (1.16 and 0.87 mmol/L, respectively, p = 0.03) and atherogenic index (3.45 and 6.73, respectively, p = 0.002). Conclusion: The study results indicate that diabetes mellitus is often diagnosed in very elderly patients with CAD. In very elderly pa-How to cite this paper: Topolyanskaya,

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“…The HbA1c level of diagnosed T2DM was obtained from ADDITION-Europe usual care arm with the HbA1c level of 7.0 % [ 24 ]. For undiagnosed T2DM state, we applied the HbA1c level of 8.5 % among those diagnosed clinically with T2DM within the past 6 months [ 23 ]. For diabetic complications, the mean HbA1c level of 9.1 % was derived from a study in China [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Economic evaluation of population-based type 2 diabetes mellitus screening at different healthcare settings in Vietnam

Toi

Thavorncharoensap

et al. 2021

PLoS ONE

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Introduction Few economic evaluations have assessed the cost-effectiveness of screening type-2 diabetes mellitus (T2DM) in different healthcare settings. This study aims to evaluate the value for money of various T2DM screening strategies in Vietnam. Methods A decision analytical model was constructed to compare costs and quality-adjusted life years (QALYs) of T2DM screening in different health care settings, including (1) screening at commune health station (CHS) and (2) screening at district health center (DHC), with no screening as the current practice. We further explored the costs and QALYs of different initial screening ages and different screening intervals. Cost and utility data were obtained by primary data collection in Vietnam. Incremental cost-effectiveness ratios were calculated from societal and payer perspectives, while uncertainty analysis was performed to explore parameter uncertainties. Results Annual T2DM screening at either CHS or DHC was cost-effective in Vietnam, from both societal and payer perspectives. Annual screening at CHS was found as the best screening strategy in terms of value for money. From a societal perspective, annual screening at CHS from initial age of 40 years was associated with 0.40 QALYs gained while saving US$ 186.21. Meanwhile, one-off screening was not cost-effective when screening for people younger than 35 years old at both CHS and DHC. Conclusions T2DM screening should be included in the Vietnamese health benefits package, and annual screening at either CHS or DHC is recommended.

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Characteristics of Newly Diagnosed Type 2 Diabetes in Chinese Older Adults: A National Prospective Cohort Study

Cited by 11 publications

References 26 publications

Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics

Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics

Diabetes Mellitus in Very Elderly Russian Patients with Coronary Artery Disease

Economic evaluation of population-based type 2 diabetes mellitus screening at different healthcare settings in Vietnam

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Characteristics of Newly Diagnosed Type 2 Diabetes in Chinese Older Adults: A National Prospective Cohort Study

Cited by 11 publications

References 26 publications

Screening Cardiovascular Risk Factors of Diabetes Patients in the&nbsp;Primary Diabetes Clinics

Screening Cardiovascular Risk Factors of Diabetes Patients in the&nbsp;Primary Diabetes Clinics

Diabetes Mellitus in Very Elderly Russian Patients with Coronary Artery Disease

Economic evaluation of population-based type 2 diabetes mellitus screening at different healthcare settings in Vietnam

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Product

Resources

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Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics

Screening Cardiovascular Risk Factors of Diabetes Patients in the Primary Diabetes Clinics