Characteristics of osteoarthritis among Kuwaitis: A hospital-based study

Malaviya, Anand N.; Shehab, Diaa; Bhargava, Sarah; Al-Jarallah, Khaled; Al-Awadi, A.; Sharma, Promila; Al-Ghuriear, S.; Al-Shugayer, A.

doi:10.1007/bf01451049

Cited by 14 publications

(16 citation statements)

References 17 publications

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“…All non-European data, whether direct surveys of disease, clinic data of symptomatic patients, or comparative international rates of total hip replacement, have consistently shown the infrequency of primary osteoarthritis in these populations. This is in contrast to the knee, for which there are many reports of osteoarthritis from these countries, showing a rate of primary osteoarthritis that is many times that of hip osteoarthritis 15,21,23 .…”

Section: Worldwide Epidemiologymentioning

confidence: 89%

Primary Osteoarthritis of the Hip: A Genetic Disease Caused by European Genetic Variants

Hoaglund

2013

Journal of Bone and Joint Surgery

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Primary osteoarthritis of the hip is a separate phenotype that occurs at a rate of 3% to 6% in the populations of the world with European ancestry. In all non-European populations, there is a consistent rarity of primary osteoarthritis that suggests a different etiology for these few patients. Family, sibling, and twin studies prove primary osteoarthritis to be a genetic disease with a 50% heritability caused by European genetic variants. The genetic basis is reinforced by the lower rate of primary osteoarthritis in American minorities consistent with their degree of European gene admixture. Whether the mechanism of degeneration of primary osteoarthritis may be secondary through a morphologic deformity, such as femoroacetabular impingement, remains unknown. The virtual absence of the disease in non-Europeans indicates that the European gene component is necessary for the expression of this separate phenotype of osteoarthritis.

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Section: Worldwide Epidemiologymentioning

confidence: 89%

Primary Osteoarthritis of the Hip: A Genetic Disease Caused by European Genetic Variants

Hoaglund

2013

Journal of Bone and Joint Surgery

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“…According to previous studies, obesity in Kuwait is increasing , is among the highest in the Gulf states (Al- Moussa, 1996;Musaiger & Sullivan, 1998), and is speculated to be related to the high mortality rate from CHD (Al- Moussa, 1996;Akanji et al, 1999), osteoarthritis (Malaviya et al, 1998), and diabetes mellitus (Emara et al, 1989;Alwan & King, 1992;Abdella et al, 1995) seen in Kuwait.…”

Section: Introductionmentioning

confidence: 99%

“…There have been several studies of single risk factors for chronic diseases in Kuwait, such as studies of overweight and obesity (Emara et al, 1989;Al-Isa, 1995, 1997a,b, 1999aAkanji et al, 1999;Al-Awadi & Amine, 1989;Malaviya et al, 1998;Moussa et al, 1999) or diabetes mellitus (Abdella et al, 1995(Abdella et al, , 1998(Abdella et al, , 1999. However, most of these studies have focused on children (Al-Isa, 1999a,b;Moussa et al, 1999), college students or other young adults (up to age 40 y) (AlIsa, 1995(AlIsa, , 1997a(AlIsa, ,b, 1999aAkanji et al, 1999;Al-Awadi & Amine, 1989).…”

Section: Introductionmentioning

confidence: 99%

Multiple coronary risk factors in healthy older Kuwaiti males

et al. 2002

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Objective: The objective was to examine the percentage and severity of obesity and some common biochemical coronary heart disease (CHD) risk factors in a sample of healthy Kuwaiti adult males ! 45 y of age. We also sought to determine the percentage of males at increased risk due to the presence of multiple CHD risk factors. Design: The study was a cross-sectional study. Setting: The study was conducted in all men who underwent a mandatory job related physical examination or who sought to obtain retirement benefits. Subjects: A total of 740 healthy Kuwaiti males between the ages of 45 to 80 y. Results: In all, 37% of the men were obese, 26% had elevated glucose values and 52% had elevated or high cholesterol levels. Some had multiple risk factors for CHD, including age ! 45 y, obesity, male gender, hyperglycemia and hypercholesterolemia. Blood glucose values increased consistently from younger (45 -54 y) to older age groups (55 -64 and ! 65 y). Blood glucose values varied inversely with education level. Conclusions: In societies with relatively uniform income levels, educational level may be a better indicator of chronic disease risk than income per se. These results, showing a high percentage of men with several risk factors and high mean values, suggesting more severe risk, suggest that immediate action should be taken to develop a public health intervention strategy to educate Kuwaiti men to become aware of the causes and correlates of CHD and how to decrease their risk for CHD and heart attack, the leading cause of death in Kuwait.

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“…Knee OA is common in Kuwait [12,13] yet no specific factors have been studied so far. Two genetic studies did not reveal any association with knee OA [14,15].…”

Section: Introductionmentioning

confidence: 99%

Are 25(OH)D Levels Related to the Severity of Knee Osteoarthritis and Function?

Al-Jarallah¹,

Shehab²,

Al-Awadhi³

et al. 2011

Med Princ Pract

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Objective: To investigate the effect of 25-hydroxyvitamin D [25(OH)D] in Kuwaiti patients with primary knee osteoarthritis (OA) and to assess its relation with radiological grading and functional status. Subjects and Methods: In this cross-sectional study, 25(OH)D was measured using radioimmunoassay in 99 patients [90 women and 9 men; mean age 56.5 ± 9.1 years (range: 36–80)] with clinical and radiological findings of primary knee OA. X-ray grading using the Kellgren-Lawrence grading scale and the Osteoarthritis Research Society International (OARSI) Atlas grading scale and functional assessments using Lequesne’s indices were evaluated in relation to the 25(OH)D level. Other variables studied were age at onset of symptoms, body mass index and duration of disease. Results: The age of the patients at the onset and the duration of disease were 51.58 ± 7.14 and 3.88 ± 2.51 years, respectively. Mean scoring for functional assessment was 10.31 ± 4.35 and mean Kellgren-Lawrence radiological grading was 2.43 ± 0.85. Radiological finding according to the OARSI Atlas revealed joint space narrowing of grades 2–3 in 87 (87.9%) patients and the presence of osteophytes in 55 (55.6%) patients. The mean value of 25(OH)D level was 11.4 ± 6.07 ng/ml. Of the 99 patients, 92 (92.9%) were vitamin D deficient. Comparison of 25(OH)D levels to radiological findings and different functional classes showed no significant association. Conclusion: Most of our patients had vitamin D deficiency, but the level of 25(OH)D was not related to the severity of the knee X-ray grading or to the functional assessment in our patients with primary knee OA.

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Characteristics of osteoarthritis among Kuwaitis: A hospital-based study

Cited by 14 publications

References 17 publications

Primary Osteoarthritis of the Hip: A Genetic Disease Caused by European Genetic Variants

Primary Osteoarthritis of the Hip: A Genetic Disease Caused by European Genetic Variants

Multiple coronary risk factors in healthy older Kuwaiti males

Are 25(OH)D Levels Related to the Severity of Knee Osteoarthritis and Function?

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