Characteristics of patients with dual infection by hepatitis B and C viruses

Zarski, Jean–Pierre; Bohn, Benoit; Bastie, Anne; Pawlotsky, Jean‐Michel; Baud, Maryline; Bost-Bezeaux, Frédérique; Nhieu, Jeanne Tran Van; Seigneurin, Jean‐Marie; Buffet, Catherine; Dhumeaux, Daniel

doi:10.1016/s0168-8278(98)80198-0

Cited by 335 publications

(277 citation statements)

References 26 publications

Supporting

Mentioning

245

Contrasting

Unclassified

Order By: Relevance

“…[7][8][9] Several factors such as alcohol abuse, coinfection with HBV or HIV, gender or age at infection determine the highly variable course of liver disease in hepatitis C virus (HCV) infection. 5,[10][11][12] Besides, the hepatocellular injury in patients with CHC results from the host's immunemediated responses to viral infection. In this respect, the host's immunogenetic make-up plays an important role in determining the natural history of CHC.…”

Section: Introductionmentioning

confidence: 99%

Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection

et al. 2005

View full text Add to dashboard Cite

Immune response to viral infection is an important determinant of liver injury in chronic hepatitis C (CHC). Experimental and clinical data suggest a protective role of interleukin-10 (IL-10) in hepatic fibrogenesis. The significance of two SNPs of the interleukin-10 receptor 1 (IL-10R1), S138G (SNP3) and G330R (SNP4) was investigated on (i) susceptibility to CHC, (ii) progression of hepatic fibrosis and (iii) response to interferon/ribavirin therapy. DNA and liver biopsies were obtained from 212 patients with HCV (hepatitis C virus)-genotype-1 infection. The allele frequencies were 0.17 for SNP3 and 0.33 for SNP4, both of which were indifferent from healthy controls (0.17 and 0.32, respectively). Stage 1 liver fibrosis was found in 22 cases (10.4%), stage 2 in 108 (50.9%), stage 3 in 27 (12.8%), and stage 4 (cirrhosis) in 55 (25.9%). An association was found between the SNP4 allele and the presence of cirrhosis (P ¼ 0.01). Homozygous SNP4 individual variants segregated within the cirrhosis group (P ¼ 0.03). We found neither an association with SNP3 nor with the necroinflammatory disease activity (as measured by ALT levels) nor with the response to antiviral therapy. Our work implies that IL-10R1 SNP4 is a recessively inherited risk factor for hepatic cirrhosis in HCV genotype-1 infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection

et al. 2005

View full text Add to dashboard Cite

show abstract

“…5,6 Alcohol intake and coinfection with hepatitis B virus (HBV) or human immunodeficiency virus (HIV) have been clearly proven to accelerate fibrosis progression and development of end-stage liver complications in HCV patients. [7][8][9] As far as host factors are concerned, age at infection, 10 male sex, 11 immunosuppression, and presence of metabolic syndrome and/or of type II diabetes have all been associated with more severe and progressive liver disease. [12][13][14] Increasing evidence indicates that genetic factors may have a major influence on the natural history of chronic liver disease of different etiologies, including hepatitis C. Special interest has been focused on the identification of candidate genes involved in hepatic fibrogenesis, considering that liver fibrosis, the hallmark of liver disease progression to cirrhosis, is a dynamic process in which multiple genes are likely to interact with environmental factors.…”

mentioning

confidence: 99%

A Seven-Gene Signature (Cirrhosis Risk Score) Predicts Liver Fibrosis Progression in Patients with Initially Mild Chronic Hepatitis C†

et al. 2009

View full text Add to dashboard Cite

Fibrosis progression is the main determinant of liver disease outcome in chronic hepatitis C, being influenced by environmental and host factors. Recently, a cirrhosis risk score (CRS) based on seven single-nucleotide polymorphisms was proposed as genetic predictor of cirrhosis in hepatitis C. To assess the role of CRS in predicting fibrosis progression in patients with initially no or minimal to moderate fibrosis, we investigated 271 untreated patients with chronic hepatitis C having initial liver biopsy showing METAVIR stage F0 (n ‫؍‬ 104), F1 (n ‫؍‬ 101), or F2 (n ‫؍‬ 59) who had been followed up without antiviral therapies for at least 60 months (mean 108.5 ؎ 71.5 months) and had a liver biopsy at the end of this observation period. Of these, 24.4% showed no histologic progression, 75.6% progressed by at least one stage, 45.0% progressed by at least two stages, and 10.3% progressed by more than two stages. The mean CRS was significantly higher (P ‫؍‬ 0.005) in patients with fibrosis progression compared with those without progression, and this difference was particularly evident (P ‫؍‬ 0.002) with F0 on initial biopsy. Mean CRS scores were not associated with degree of fibrosis progression. The relative risk of fibrosis progression increased with increasing CRS values. This association was significant in males but not in females and was most evident in males with F0 at initial biopsy (odds ratio 16.5, 95% confidence interval 1.6-166; P‫؍‬ 0.02) in the presence of high CRS. Multivariate analysis confirmed the significant association of CRS score with fibrosis progression. The predictive value of CRS was confirmed in hepatitis C virus patients admitting significant alcohol intake. Conclusion: Host genetics defined by CRS predict fibrosis progression in males with initially mild chronic hepatitis C and may become a useful parameter for prognostic evaluation and treatment decision.

show abstract

“…Previous studies of HBV and HCV co-infections have revealed viral interference between these hepatotropic viruses resulting either in one dominant virus [43] or in some cases resolution of both infections [44] . The exact mechanism of this interference is not known, although data suggest it is the result of inhibition of replication by viral proteins [45,46] . It is also plausible that the existing activation of non-specific immune responses within the liver during the current HBV infection enhances the clearance of the HCV infection.…”

mentioning

confidence: 99%

Factors influencing a low rate of hepatitis C viral RNA clearance in heroin users from Southern China

Garten¹,

Lai²,

Zhang³

et al. 2008

WJG

View full text Add to dashboard Cite

INTRODUCTIONThe hepatitis C virus (HCV) epidemic now affects over 200 million people worldwide. HCV is a single-stranded RNA flavivirus that is responsible for the majority of non-A-non-B hepatitis infections [1,2] . Natural history studies have found that 15%-59% of people who are infected with HCV will undergo spontaneous viral clearance with no further liver disease due to HCV [3][4][5][6][7][8][9][10][11] . The remaining will develop chronic HCV infection that can lead to cirrhosis, hepatocellular carcinoma and the need for a liver transplant.The exact mechanism of HCV RNA clearance is not well understood although recent studies have shown that clearance is associated with strong, broad cellular immune responses [12][13][14][15][16][17][18][19] . Other factors such as younger age [3,20] , female gender [21,22] , presence of hepatitis B surface antigen (HBsAg) [3,23] , certain HLA alleles [6,[24][25][26][27][28][29] , and low viral quasispecies diversity [30] have been linked to increased HCV RNA clearance. While African American ethnicity [3,25] , HCV genotype 1 [31][32][33] and co-infections with human immunodeficiency virus-1 (HIV-1) [3] , Human T-Lymphotropic Virus-1 [34] and Schistosoma mansoni [35] have been associated with lower HCV RNA clearance and higher HCV RNA levels. Understanding why and how individuals clear HCV is the key to developing new drugs and an effective vaccine [21] .Studies of heroin users from Guangxi Zhuang Autonomous Region in southern China have attributed the appearance and spread of HIV, HCV and other infectious agents to the change in heroin using patterns from smoking to injection [36] . Abstract AIM: To s t u d y t h e v i r o l o g i c a l a n d h o s t fa c t o r s influencing hepatitis C infection outcomes in heroin users in southern China. METHODS:HCV RNA and associated factors were analyzed among 347 heroin users from Guangxi Zhuang Autonomous Region, southern China who were hepatitis C virus (HCV) EIA positive for two or more consecutive visits. RESULTS:Using the COBAS AMPLICOR HCV TEST, a remarkably low HCV RNA negative rate of 8.6% was detected. After multivariate logistic regression analysis, HCV RNA clearance was significantly associated with the presence of HBsAg (OR = 8.436, P < 0.0001), the lack of HIV-1 infection (OR = 0.256, P = 0.038) and age younger than 25 (OR = 0.400, P = 0.029). CONCLUSION:Our study suggests HCV infection among Chinese heroin users results in high levels of viral persistence even amidst factors previously found to enhance viral clearance. Prospective studies of a possible genetic component within the Chinese population and the pathogenicity of non-genotype 1 HCV infections are needed. heroin trafficking routes into the province [37,38] . It is not clear how widespread the HCV epidemic is in China. Little seroprevalence data exists, mostly from the major cities of Beijing, Shanghai and Hong Kong and to our knowledge; no studies on HCV RNA clearance in China have been done. Studies in Yunnan Province, which borders Guangxi Zhuang Autonomous...

show abstract

Characteristics of patients with dual infection by hepatitis B and C viruses

Cited by 335 publications

References 26 publications

Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection

Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection

A Seven-Gene Signature (Cirrhosis Risk Score) Predicts Liver Fibrosis Progression in Patients with Initially Mild Chronic Hepatitis C†

Factors influencing a low rate of hepatitis C viral RNA clearance in heroin users from Southern China

Contact Info

Product

Resources

About